This is a Validated Antibody Database (VAD) review about dog PKP3, based on 4 published articles (read how Labome selects the articles), using PKP3 antibody in all methods. It is aimed to help Labome visitors find the most suited PKP3 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
PKP3 synonym: plakophilin-3

Invitrogen
mouse monoclonal (23E3/4)
  • immunocytochemistry; mouse; 1:250; fig 1
In order to explore the role of desmosomal cadherins in carcinogenesis, Invitrogen PKP3 antibody (Zymed, 23E3/4) was used in immunocytochemistry on mouse samples at 1:250 (fig 1). PLoS ONE (2012) ncbi
mouse monoclonal (23E3/4)
  • western blot; human; 1:1000
In order to investigate the effects of K8 filament stabilization, Invitrogen PKP3 antibody (Zymed, 23E3-4) was used in western blot on human samples at 1:1000. PLoS ONE (2012) ncbi
mouse monoclonal (23E3/4)
  • immunocytochemistry; human; 1:25; fig 5
  • western blot; human; 1:1000; fig 2
In order to test if plakophilin3 is required for desmosome formation, Invitrogen PKP3 antibody (Zymed, clone 23E3-4) was used in immunocytochemistry on human samples at 1:25 (fig 5) and in western blot on human samples at 1:1000 (fig 2). Cell Mol Life Sci (2011) ncbi
mouse monoclonal (23E3/4)
  • chromatin immunoprecipitation; human; fig 3
  • immunocytochemistry; human; fig 2
  • immunohistochemistry; human; fig 5
  • western blot; human; fig 1
In order to show that PKP3 is transcriptionally repressed by ZEB1 in metastatic cancer cells, Invitrogen PKP3 antibody (Zymed Laboratories, 23E3/4) was used in chromatin immunoprecipitation on human samples (fig 3), in immunocytochemistry on human samples (fig 2), in immunohistochemistry on human samples (fig 5) and in western blot on human samples (fig 1). FEBS Lett (2007) ncbi
Articles Reviewed
  1. Baron S, Hoang A, Vogel H, Attardi L. Unimpaired skin carcinogenesis in Desmoglein 3 knockout mice. PLoS ONE. 2012;7:e50024 pubmed publisher
  2. Khapare N, Kundu S, Sehgal L, Sawant M, Priya R, Gosavi P, et al. Plakophilin3 loss leads to an increase in PRL3 levels promoting K8 dephosphorylation, which is required for transformation and metastasis. PLoS ONE. 2012;7:e38561 pubmed publisher
  3. Gosavi P, Kundu S, Khapare N, Sehgal L, Karkhanis M, Dalal S. E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly. Cell Mol Life Sci. 2011;68:1439-54 pubmed publisher
  4. Aigner K, Descovich L, Mikula M, Sultan A, Dampier B, Bonne S, et al. The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression. FEBS Lett. 2007;581:1617-24 pubmed