This is a Validated Antibody Database (VAD) review about dog MAPK3, based on 31 published articles (read how Labome selects the articles), using MAPK3 antibody in all methods. It is aimed to help Labome visitors find the most suited MAPK3 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
MAPK3 synonym: mitogen-activated protein kinase 3

Invitrogen
rabbit monoclonal (15H10L7)
  • western blot; rat; loading ...; fig 4a
Invitrogen MAPK3 antibody (Thermo Fisher Scientific, 700012) was used in western blot on rat samples (fig 4a). Biosci Rep (2018) ncbi
mouse monoclonal (ERK-7D8)
  • immunoprecipitation; human; loading ...; fig 5a
  • western blot; human; loading ...; fig 5a
In order to study the effect of symplekin on cellular proliferation and dedifferentiation, Invitrogen MAPK3 antibody (Invitrogen, 13-6200) was used in immunoprecipitation on human samples (fig 5a) and in western blot on human samples (fig 5a). Sci Rep (2017) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; human; 1:500; loading ...; fig 3a
In order to elucidate the mechanism of Pin1 overexpression in hepatocellular carcinoma, Invitrogen MAPK3 antibody (Invitrogen, 13-6200) was used in western blot on human samples at 1:500 (fig 3a). Sci Rep (2017) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; human; fig 5e
In order to elucidate how JNJ-61186372 attenuates therapeutic resistance in patients with epidermal growth factor receptor mutations, Invitrogen MAPK3 antibody (Invitrogen, 13-6200) was used in western blot on human samples (fig 5e). MAbs (2017) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; human; 1:2000; loading ...; fig 2a
In order to describe the antitumoral mechanism of vitamin C in KRAS mutant colorectal cancer that is related to the Warburg effect, Invitrogen MAPK3 antibody (Thermo Fisher Scientific, ERK-7D8) was used in western blot on human samples at 1:2000 (fig 2a). Oncotarget (2016) ncbi
mouse monoclonal (ERK-6B11)
  • immunohistochemistry - paraffin section; mouse; fig 3
  • western blot; mouse; fig 3
In order to elucidate the role of ERK isoforms to auditory function, Invitrogen MAPK3 antibody (Invitrogen, 13-8600) was used in immunohistochemistry - paraffin section on mouse samples (fig 3) and in western blot on mouse samples (fig 3). Sci Rep (2015) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; human; fig 1
In order to show that inhibition of the oxidative arm of the pentose phosphate pathway is required for antimalarial-mediated apoptosis, Invitrogen MAPK3 antibody (Invitrogen, 13-6200) was used in western blot on human samples (fig 1). Oncogene (2016) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; mouse; 1:500; fig 5b
In order to uncover a role for ATG12-ATG3 in late endosome function that is distinct from autophagy, Invitrogen MAPK3 antibody (Zymed, 13-6200) was used in western blot on mouse samples at 1:500 (fig 5b). Nat Cell Biol (2015) ncbi
rabbit monoclonal (15H10L7)
  • western blot; human
In order to identify binding partners ANKHD1 in leukemia cells, Invitrogen MAPK3 antibody (Invitrogen, 700012) was used in western blot on human samples . Biochim Biophys Acta (2015) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; human
In order to study the effect of Imatinib on VASP activity and its interaction with Zyxin in BCR-ABL leukemic cells, Invitrogen MAPK3 antibody (Zymed, 13-6200) was used in western blot on human samples . Biochim Biophys Acta (2015) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; mouse
In order to investigate the role of Ras in the production of effector cytokines by primary murine CD4+ T cells during Th1/Th2 differentiation, Invitrogen MAPK3 antibody (Invitrogen, 13-6200) was used in western blot on mouse samples . PLoS ONE (2014) ncbi
rabbit monoclonal (K.913.4)
  • immunohistochemistry - paraffin section; zebrafish
  • western blot; zebrafish
In order to show that H2O2 acts via MAPK signaling for heart regeneration in adult zebrafish, Invitrogen MAPK3 antibody (Pierce, MA5-15134) was used in immunohistochemistry - paraffin section on zebrafish samples and in western blot on zebrafish samples . Cell Res (2014) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; human
In order to study the effect of Hinokitiol on DNA damage and autophagy in gefitinib-resistant lung adenocarcinoma cells, Invitrogen MAPK3 antibody (Zymed Laboratories, 13-6200) was used in western blot on human samples . PLoS ONE (2014) ncbi
mouse monoclonal (ERK-6B11)
  • western blot; mouse; 1:3000; fig 3
In order to generate and characterize mice conditionally deleted for Ngf or Trka in the central nervous system, Invitrogen MAPK3 antibody (Zymed, ERK-6B11) was used in western blot on mouse samples at 1:3000 (fig 3). J Neurosci (2012) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; rat; 1:2500; tbl 1
In order to study the effects of taurine on antidepressive behaviour and depression-related signaling in the rat hippocampus, Invitrogen MAPK3 antibody (Invitrogen, 136200) was used in western blot on rat samples at 1:2500 (tbl 1). Amino Acids (2012) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; human
In order to determine the impact of IRS1 on the BCR-ABL signaling pathways, Invitrogen MAPK3 antibody (Zymed, 13-6200) was used in western blot on human samples . Biochim Biophys Acta (2011) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; human; fig 1
In order to examine the phosphorylation of insulin-receptors substrate in various adenoma and adipocytes, Invitrogen MAPK3 antibody (Invitrogen, 13-6200) was used in western blot on human samples (fig 1). J Endocrinol Invest (2011) ncbi
mouse monoclonal (ERK-6B11)
  • western blot; mouse; 1:3000
In order to study molecular pathways required for fear learning, Invitrogen MAPK3 antibody (Zymed, 13-8600) was used in western blot on mouse samples at 1:3000. J Neurosci (2009) ncbi
mouse monoclonal (ERK-6B11)
  • western blot; human; fig 5
In order to demonstrate that phosphatase of activated cells 1 phosphatase is a direct transcription target of E2F-1 and mediates apoptosis, Invitrogen MAPK3 antibody (Zymed Laboratories, 13-8600) was used in western blot on human samples (fig 5). Oncogene (2007) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; mouse; fig 2a
In order to study the link between Ras activity and T cell anergy, Invitrogen MAPK3 antibody (Zymed, 13-6200) was used in western blot on mouse samples (fig 2a). Nat Immunol (2006) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; rat; fig 6
In order to test if ischemic post conditioning is protective in remodeled myocardium, Invitrogen MAPK3 antibody (Zymed, ERK-7D8) was used in western blot on rat samples (fig 6). Cardiovasc Res (2006) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; rat; fig 7
In order to examine the effects of MCP-1 on the migration of smooth muscle cells and the pathways modulated, Invitrogen MAPK3 antibody (Zymed, ERK-7D8) was used in western blot on rat samples (fig 7). J Biomed Sci (2005) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; rat; 1:5000; fig 2
In order to determine the roles of ERK1/2 in modulating intracellular calcium concentrations, calcium sensitivity, and the 20-kDa myosin light chain phosphorylation during contraction activated by U46619 treatment in rat tail artery strips, Invitrogen MAPK3 antibody (Zymed, ERK-7D8) was used in western blot on rat samples at 1:5000 (fig 2). Life Sci (2005) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; rat; fig 5
In order to study S1P(1)-triggered and G(i)-Ras-ERK/p38 MAPK-KLF5-dependent regulation of PDGF gene transcription in vascular smooth muscle cells, Invitrogen MAPK3 antibody (Zymed, 13-6200,) was used in western blot on rat samples (fig 5). J Biol Chem (2004) ncbi
mouse monoclonal (ERK-6B11)
  • western blot; rat; fig 3
In order to test if an increase in fat cell size modulates signaling pathways by changing the relationships between the cell and the extracellular matrix, Invitrogen MAPK3 antibody (Zymed, 13-8600) was used in western blot on rat samples (fig 3). Int J Obes Relat Metab Disord (2003) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; human; fig 2
In order to determine the effect of lysophosphatidic acid, sphingosine 1-phosphate, and epidermal growth factor on a human astrocytoma cell line, Invitrogen MAPK3 antibody (Zymed Laboratories, clone ERK-7D8) was used in western blot on human samples (fig 2). J Neurochem (2000) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; rat
In order to examine Ras-GTP and Ras-GDP at low temperatures in vivo, Invitrogen MAPK3 antibody (Zymed, 13-6200) was used in western blot on rat samples . J Clin Invest (1999) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; mouse; fig 1, 2
In order to compare the effect of cold water stress on the phosphorylation of brain tau protein in ob/ob and ob/+ mice, Invitrogen MAPK3 antibody (Zymed, 13-6200) was used in western blot on mouse samples (fig 1, 2). Neurochem Res (1998) ncbi
mouse monoclonal (ERK-7D8)
  • immunoprecipitation; mouse
  • western blot; mouse
In order to elucidate Ras-mediated tumorigenicity, Invitrogen MAPK3 antibody (Zymed, ERK-7D8) was used in immunoprecipitation on mouse samples and in western blot on mouse samples . Proc Natl Acad Sci U S A (1998) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; common platanna; 1:1000; fig 1
In order to identify the cleavage site for anthrax lethal toxin, Invitrogen MAPK3 antibody (Zymed, ERK-7D8) was used in western blot on common platanna samples at 1:1000 (fig 1). Science (1998) ncbi
mouse monoclonal (ERK-7D8)
  • western blot; human; fig 3
In order to test if ligation of PSGL-1 transmits signals into leukocytes, Invitrogen MAPK3 antibody (Zymed Laboratories, clone ERK-7D8) was used in western blot on human samples (fig 3). J Biol Chem (1997) ncbi
Articles Reviewed
  1. Ahmad F, Salahuddin M, Alsamman K, Herzallah H, Al Otaibi S. Neonatal maternal deprivation impairs localized de novo activity-induced protein translation at the synapse in the rat hippocampus. Biosci Rep. 2018;38: pubmed publisher
  2. Zhang C, Mao H, Cao Y. Nuclear accumulation of symplekin promotes cellular proliferation and dedifferentiation in an ERK1/2-dependent manner. Sci Rep. 2017;7:3769 pubmed publisher
  3. Yan X, Zhu Z, Xu S, Yang L, Liao X, Zheng M, et al. MicroRNA-140-5p inhibits hepatocellular carcinoma by directly targeting the unique isomerase Pin1 to block multiple cancer-driving pathways. Sci Rep. 2017;7:45915 pubmed publisher
  4. Grugan K, Dorn K, Jarantow S, Bushey B, Pardinas J, Laquerre S, et al. Fc-mediated activity of EGFR x c-Met bispecific antibody JNJ-61186372 enhanced killing of lung cancer cells. MAbs. 2017;9:114-126 pubmed publisher
  5. Aguilera O, Muñoz Sagastibelza M, Torrejón B, Borrero Palacios A, del Puerto Nevado L, Martínez Useros J, et al. Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer. Oncotarget. 2016;7:47954-47965 pubmed publisher
  6. Kurioka T, Matsunobu T, Satoh Y, Niwa K, Endo S, Fujioka M, et al. ERK2 mediates inner hair cell survival and decreases susceptibility to noise-induced hearing loss. Sci Rep. 2015;5:16839 pubmed publisher
  7. Salas E, Roy S, Marsh T, Rubin B, Debnath J. Oxidative pentose phosphate pathway inhibition is a key determinant of antimalarial induced cancer cell death. Oncogene. 2016;35:2913-22 pubmed publisher
  8. Murrow L, Malhotra R, Debnath J. ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. Nat Cell Biol. 2015;17:300-10 pubmed publisher
  9. Machado Neto J, Lazarini M, Favaro P, de Melo Campos P, Scopim Ribeiro R, Franchi Junior G, et al. ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells. Biochim Biophys Acta. 2015;1853:583-93 pubmed publisher
  10. Bernusso V, Machado Neto J, Pericole F, Vieira K, Duarte A, Traina F, et al. Imatinib restores VASP activity and its interaction with Zyxin in BCR-ABL leukemic cells. Biochim Biophys Acta. 2015;1853:388-95 pubmed publisher
  11. Janardhan S, Marks R, Gajewski T. Primary murine CD4+ T cells fail to acquire the ability to produce effector cytokines when active Ras is present during Th1/Th2 differentiation. PLoS ONE. 2014;9:e112831 pubmed publisher
  12. Han P, Zhou X, Chang N, Xiao C, Yan S, Ren H, et al. Hydrogen peroxide primes heart regeneration with a derepression mechanism. Cell Res. 2014;24:1091-107 pubmed publisher
  13. Li L, Wu P, Lee J, Li P, Hsieh W, Ho C, et al. Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells. PLoS ONE. 2014;9:e104203 pubmed publisher
  14. Muller M, Triaca V, Besusso D, Costanzi M, Horn J, Koudelka J, et al. Loss of NGF-TrkA signaling from the CNS is not sufficient to induce cognitive impairments in young adult or intermediate-aged mice. J Neurosci. 2012;32:14885-98 pubmed publisher
  15. Iio W, Matsukawa N, Tsukahara T, Toyoda A. The effects of oral taurine administration on behavior and hippocampal signal transduction in rats. Amino Acids. 2012;43:2037-46 pubmed publisher
  16. Machado Neto J, Favaro P, Lazarini M, Costa F, Olalla Saad S, Traina F. Knockdown of insulin receptor substrate 1 reduces proliferation and downregulates Akt/mTOR and MAPK pathways in K562 cells. Biochim Biophys Acta. 2011;1813:1404-11 pubmed publisher
  17. Urbanet R, Pilon C, Giorgino F, Vettor R, Fallo F. Insulin signaling in adipose tissue of patients with primary aldosteronism. J Endocrinol Invest. 2011;34:86-9 pubmed
  18. Musumeci G, Sciarretta C, Rodríguez Moreno A, Al Banchaabouchi M, Negrete Díaz V, Costanzi M, et al. TrkB modulates fear learning and amygdalar synaptic plasticity by specific docking sites. J Neurosci. 2009;29:10131-43 pubmed publisher
  19. Wu J, Jin Y, Calaf G, Huang W, Yin Y. PAC1 is a direct transcription target of E2F-1 in apoptotic signaling. Oncogene. 2007;26:6526-35 pubmed
  20. Zha Y, Marks R, Ho A, Peterson A, Janardhan S, Brown I, et al. T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-alpha. Nat Immunol. 2006;7:1166-73 pubmed
  21. Zhu M, Feng J, Lucchinetti E, Fischer G, Xu L, Pedrazzini T, et al. Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway. Cardiovasc Res. 2006;72:152-62 pubmed
  22. Lo I, Shih J, Jiang M. Reactive oxygen species and ERK 1/2 mediate monocyte chemotactic protein-1-stimulated smooth muscle cell migration. J Biomed Sci. 2005;12:377-88 pubmed
  23. Tsai M, Jiang M. Extracellular signal-regulated kinase1/2 in contraction of vascular smooth muscle. Life Sci. 2005;76:877-88 pubmed
  24. Usui S, Sugimoto N, Takuwa N, Sakagami S, Takata S, Kaneko S, et al. Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. J Biol Chem. 2004;279:12300-11 pubmed
  25. Farnier C, Krief S, Blache M, Diot Dupuy F, Mory G, Ferre P, et al. Adipocyte functions are modulated by cell size change: potential involvement of an integrin/ERK signalling pathway. Int J Obes Relat Metab Disord. 2003;27:1178-86 pubmed
  26. Hernandez M, Barrero M, Crespo M, Nieto M. Lysophosphatidic acid inhibits Ca2+ signaling in response to epidermal growth factor receptor stimulation in human astrocytoma cells by a mechanism involving phospholipase C(gamma) and a G(alphai) protein. J Neurochem. 2000;75:1575-82 pubmed
  27. Chan E, Stang S, Bottorff D, Stone J. Hypothermic stress leads to activation of Ras-Erk signaling. J Clin Invest. 1999;103:1337-44 pubmed
  28. Korneyev A. Stress-induced tau phosphorylation in mouse strains with different brain Erk 1 + 2 immunoreactivity. Neurochem Res. 1998;23:1539-43 pubmed
  29. Webb C, Van Aelst L, Wigler M, Vande Woude G. Signaling pathways in Ras-mediated tumorigenicity and metastasis. Proc Natl Acad Sci U S A. 1998;95:8773-8 pubmed
  30. Duesbery N, Webb C, Leppla S, Gordon V, Klimpel K, Copeland T, et al. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science. 1998;280:734-7 pubmed
  31. Hidari K, Weyrich A, Zimmerman G, McEver R. Engagement of P-selectin glycoprotein ligand-1 enhances tyrosine phosphorylation and activates mitogen-activated protein kinases in human neutrophils. J Biol Chem. 1997;272:28750-6 pubmed