This is a Validated Antibody Database (VAD) review about dog MAP2K4, based on 9 published articles (read how Labome selects the articles), using MAP2K4 antibody in all methods. It is aimed to help Labome visitors find the most suited MAP2K4 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
MAP2K4 synonym: dual specificity mitogen-activated protein kinase kinase 4

Knockout validation
Cell Signaling Technology
rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig 5a
Cell Signaling Technology MAP2K4 antibody (Cell Signaling, 9152) was used in western blot knockout validation on human samples (fig 5a). Cell Res (2018) ncbi
Cell Signaling Technology
rabbit polyclonal
  • western blot; human; loading ...; fig 4d
Cell Signaling Technology MAP2K4 antibody (Cell Signaling, 9152) was used in western blot on human samples (fig 4d). BMC Cancer (2019) ncbi
rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig 5a
Cell Signaling Technology MAP2K4 antibody (Cell Signaling, 9152) was used in western blot knockout validation on human samples (fig 5a). Cell Res (2018) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig s5e
Cell Signaling Technology MAP2K4 antibody (Cell Signaling, 9152) was used in western blot on mouse samples (fig s5e). Nature (2017) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 6-s1c
Cell Signaling Technology MAP2K4 antibody (Cell Signaling, 9152) was used in western blot on mouse samples at 1:1000 (fig 6-s1c). elife (2017) ncbi
rabbit monoclonal (5c10)
  • western blot; human; 1:1000; loading ...; fig 6b
Cell Signaling Technology MAP2K4 antibody (Cell signaling, 3346) was used in western blot on human samples at 1:1000 (fig 6b). Oncotarget (2016) ncbi
rabbit polyclonal
  • western blot; human
In order to identify the intracellular signaling pathways by which IL-1 causes aggrecan degradation by human chondrocytes and investigate how aggrecanase activity is regulated in chondrocytes, Cell Signaling Technology MAP2K4 antibody (Cell Signaling Technology, 9152S) was used in western blot on human samples . Arthritis Rheumatol (2015) ncbi
rabbit polyclonal
  • western blot; human
Cell Signaling Technology MAP2K4 antibody (Cell Signaling Technology, 9152) was used in western blot on human samples . J Invest Dermatol (2015) ncbi
rabbit polyclonal
  • western blot; mouse
Cell Signaling Technology MAP2K4 antibody (Cell Signaling Technology, 9152) was used in western blot on mouse samples . J Biol Chem (2014) ncbi
rabbit polyclonal
  • western blot; human
In order to study the role of receptor-interacting protein 1 in cancer's response to chemotherapy, Cell Signaling Technology MAP2K4 antibody (Cell Signaling Technology, CS-9152) was used in western blot on human samples . Oncotarget (2014) ncbi
Articles Reviewed
  1. Li Z, Mbah N, Overmeyer J, Sarver J, George S, Trabbic C, et al. The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma. BMC Cancer. 2019;19:77 pubmed publisher
  2. Xue Z, Vis D, Bruna A, Sustic T, van Wageningen S, Batra A, et al. MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models. Cell Res. 2018;28:719-729 pubmed publisher
  3. Genovese G, Carugo A, TEPPER J, Robinson F, Li L, Svelto M, et al. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. 2017;542:362-366 pubmed publisher
  4. Walker L, Summers D, Sasaki Y, Brace E, Milbrandt J, DiAntonio A. MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2. elife. 2017;6: pubmed publisher
  5. Farsam V, Basu A, Gatzka M, Treiber N, Schneider L, Mulaw M, et al. Senescent fibroblast-derived Chemerin promotes squamous cell carcinoma migration. Oncotarget. 2016;7:83554-83569 pubmed publisher
  6. Ismail H, Yamamoto K, Vincent T, Nagase H, Troeberg L, Saklatvala J. Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes. Arthritis Rheumatol. 2015;67:1826-36 pubmed publisher
  7. Wu N, Huang D, Tsou H, Lin Y, Lin W. Syk mediates IL-17-induced CCL20 expression by targeting Act1-dependent K63-linked ubiquitination of TRAF6. J Invest Dermatol. 2015;135:490-498 pubmed publisher
  8. Resch U, Cuapio A, Sturtzel C, Hofer E, de Martin R, Holper Schichl Y. Polyubiquitinated tristetraprolin protects from TNF-induced, caspase-mediated apoptosis. J Biol Chem. 2014;289:25088-100 pubmed publisher
  9. Wang Q, Shi S, He W, Padilla M, Zhang L, Wang X, et al. Retaining MKP1 expression and attenuating JNK-mediated apoptosis by RIP1 for cisplatin resistance through miR-940 inhibition. Oncotarget. 2014;5:1304-14 pubmed