This is a Validated Antibody Database (VAD) review about dog KRT8, based on 37 published articles (read how Labome selects the articles), using KRT8 antibody in all methods. It is aimed to help Labome visitors find the most suited KRT8 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
KRT8 synonym: keratin, type II cytoskeletal 8

BioLegend
mouse monoclonal (1E8)
  • immunohistochemistry; mouse; loading ...; fig s6a
BioLegend KRT8 antibody (Covance, MMS-162P) was used in immunohistochemistry on mouse samples (fig s6a). Cell Rep (2018) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry; human; 1:1000; fig 2g
BioLegend KRT8 antibody (Covance, 1E8-MMS-162P) was used in immunohistochemistry on human samples at 1:1000 (fig 2g). Nat Commun (2018) ncbi
mouse monoclonal (1E8)
  • immunocytochemistry; human; 1:1000; fig 3b
In order to investigate how LACTB suppresses breast cancer cell growth, BioLegend KRT8 antibody (Covance, MMS-162P-250) was used in immunocytochemistry on human samples at 1:1000 (fig 3b). Nature (2017) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s1h
BioLegend KRT8 antibody (Covance, MMS-162P) was used in immunohistochemistry - paraffin section on mouse samples (fig s1h). Nature (2017) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry; mouse; loading ...; fig 4c
In order to demonstrate that WHSC1 drives indolent PTEN-null tumors to become metastatic prostate cancer, BioLegend KRT8 antibody (Covance, MMS-162P) was used in immunohistochemistry on mouse samples (fig 4c). J Clin Invest (2017) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 4b
In order to show that induction p53 loss in Krt8(+) mammary luminal cells leads to their clonal expansion without directly affecting their luminal identity, BioLegend KRT8 antibody (Covance, MMS-162P) was used in immunohistochemistry - paraffin section on mouse samples at 1:200 (fig 4b). Nat Commun (2017) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry - paraffin section; mouse; loading ...
In order to explore the interplay between p53 loss and Wnt/beta-catenin signaling in stem cell function and tumorigenesis, BioLegend KRT8 antibody (Covance, MMS-162P) was used in immunohistochemistry - paraffin section on mouse samples . Oncogene (2017) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 3c
BioLegend KRT8 antibody (Covance, MMS-162P) was used in immunohistochemistry - paraffin section on mouse samples at 1:1000 (fig 3c). Oncogene (2017) ncbi
mouse monoclonal (1E8)
  • immunocytochemistry; human; 1:500; loading ...; fig s1
  • western blot; human; 1:1000; loading ...; fig 2b
In order to propose that the NKX3.1-G9a-UTY transcriptional regulatory network is essential for prostate differentiation, BioLegend KRT8 antibody (Covance, MMS-162P) was used in immunocytochemistry on human samples at 1:500 (fig s1) and in western blot on human samples at 1:1000 (fig 2b). Science (2016) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry - frozen section; mouse; fig 2
BioLegend KRT8 antibody (covance, MMS-162P) was used in immunohistochemistry - frozen section on mouse samples (fig 2). Stem Cell Reports (2016) ncbi
mouse monoclonal (1E8)
  • immunocytochemistry; human; 1:300; loading ...; fig 2b
BioLegend KRT8 antibody (BioLegend, 1E8) was used in immunocytochemistry on human samples at 1:300 (fig 2b). Cell Cycle (2016) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry - paraffin section; mouse; 1:1000; fig 1
In order to study an increase in susceptibility of mice bladder cancer by conditional expression of the androgen receptor, BioLegend KRT8 antibody (Covance, MMS-162P) was used in immunohistochemistry - paraffin section on mouse samples at 1:1000 (fig 1). PLoS ONE (2016) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry; mouse; 1:500; fig 7
BioLegend KRT8 antibody (Biolegend, MMS-162P) was used in immunohistochemistry on mouse samples at 1:500 (fig 7). Oncogene (2016) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 2
  • immunocytochemistry; human; 1:100; loading ...; fig 4
BioLegend KRT8 antibody (Covance, MMS-162P-250) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig 2) and in immunocytochemistry on human samples at 1:100 (fig 4). PLoS ONE (2015) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry - frozen section; mouse; 1:2500; fig 1
In order to investigate the contribution of Wnt/beta-catenin signaling to prostatic development and tumorigenesis, BioLegend KRT8 antibody (covance, MMS-162P) was used in immunohistochemistry - frozen section on mouse samples at 1:2500 (fig 1). Stem Cells (2015) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry - paraffin section; mouse; 1:50; fig 2
BioLegend KRT8 antibody (Covance, MMS-162P) was used in immunohistochemistry - paraffin section on mouse samples at 1:50 (fig 2). PLoS ONE (2015) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry - paraffin section; mouse; fig s2
BioLegend KRT8 antibody (Covance, MMS-162P) was used in immunohistochemistry - paraffin section on mouse samples (fig s2). Cancer Res (2015) ncbi
mouse monoclonal (1E8)
  • immunocytochemistry; mouse; 1:1000
In order to identify G-protein-coupled receptor 5 (Lgr5) expression in prostate epithelial progenitor cells, BioLegend KRT8 antibody (Covance, MMS-162P) was used in immunocytochemistry on mouse samples at 1:1000. Stem Cell Reports (2015) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry - paraffin section; mouse; 1:800; fig 4
In order to elucidate role of androgen signaling in beta-catenin-initiated prostate tumorigenesis, BioLegend KRT8 antibody (Covance, MMS-162P) was used in immunohistochemistry - paraffin section on mouse samples at 1:800 (fig 4). Oncogene (2016) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry - paraffin section; mouse
BioLegend KRT8 antibody (Covance, MMS-162P) was used in immunohistochemistry - paraffin section on mouse samples . Cancer Res (2014) ncbi
mouse monoclonal (1E8)
  • western blot; mouse; 1:1000; fig 3
In order to assess MTV-Wnt1 tumors and how Wnt5a suppresses tumor formation and redirects tumor phenotype, BioLegend KRT8 antibody (Covance, MMS-162P) was used in western blot on mouse samples at 1:1000 (fig 3). PLoS ONE (2014) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry - paraffin section; mouse
In order to study the role of prolactin and STAT5 during early prostate tumorigenesis, BioLegend KRT8 antibody (Covance, MMS-162P) was used in immunohistochemistry - paraffin section on mouse samples . Am J Pathol (2014) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry - frozen section; mouse; fig 3
BioLegend KRT8 antibody (Covance, MMS-162P) was used in immunohistochemistry - frozen section on mouse samples (fig 3). Biomed Res Int (2013) ncbi
mouse monoclonal (1E8)
  • immunohistochemistry - paraffin section; mouse; 1:200
BioLegend KRT8 antibody (Covance, MMS-162P) was used in immunohistochemistry - paraffin section on mouse samples at 1:200. J Cell Biol (2013) ncbi
Invitrogen
mouse monoclonal (AE3)
  • flow cytometry; human; loading ...
In order to examine epithelial cell populations from touch samples, Invitrogen KRT8 antibody (eBioscience, 14-900-80) was used in flow cytometry on human samples . F1000Res (2016) ncbi
mouse monoclonal (AE1/AE3)
  • immunocytochemistry; mouse; 1:100; loading ...; tbl 2
In order to investigate if conditioned medium from proliferating fibroblasts induce a subset of hematopoietic cells to become adherent fibroblast-like cells, Invitrogen KRT8 antibody (eBioscience, 41-9003) was used in immunocytochemistry on mouse samples at 1:100 (tbl 2). J Cell Physiol (2016) ncbi
mouse monoclonal (AE1/AE3)
  • flow cytometry; human
  • immunocytochemistry; human; 1 ul
Invitrogen KRT8 antibody (eBioscience, 53-9003-82) was used in flow cytometry on human samples and in immunocytochemistry on human samples at 1 ul. Nanomedicine (2015) ncbi
mouse monoclonal (AE1/AE3)
  • immunohistochemistry - paraffin section; human; 1:200; fig 3
In order to study juxtacrine signaling from macrophages and monocytes and a breast cancer stem cell niche, Invitrogen KRT8 antibody (eBioscience, 53-9003-80) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig 3). Nat Cell Biol (2014) ncbi
mouse monoclonal (AE1/AE3)
  • immunocytochemistry; human; 1:100; fig 1
Invitrogen KRT8 antibody (eBioscience, AE1/AE3) was used in immunocytochemistry on human samples at 1:100 (fig 1). PLoS ONE (2013) ncbi
mouse monoclonal (6B10)
  • immunohistochemistry; human; fig 2
In order to study the expression pattern of stem cells in the bulbar conjunctival epithelium, Invitrogen KRT8 antibody (Lab Vision, 6B10) was used in immunohistochemistry on human samples (fig 2). J Cell Physiol (2010) ncbi
Sigma-Aldrich
mouse monoclonal (M20)
  • western blot; human; 1:10; loading ...; fig 2a
In order to describe a microfluidic western blot for an eight-plex protein panel for individual circulating tumor cells derived from estrogen receptor-positive breast cancer patients, Sigma-Aldrich KRT8 antibody (Sigma, C5301) was used in western blot on human samples at 1:10 (fig 2a). Nat Commun (2017) ncbi
mouse monoclonal (M20)
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 5c
  • immunocytochemistry; human; 1:250; loading ...; fig 1c
In order to determine the role of 420 kinases in bi-lineage triple-negative breast cancer, Sigma-Aldrich KRT8 antibody (Sigma, C5301) was used in immunohistochemistry - paraffin section on human samples at 1:200 (fig 5c) and in immunocytochemistry on human samples at 1:250 (fig 1c). Oncotarget (2016) ncbi
mouse monoclonal (M20)
  • immunoprecipitation; human; fig 3
  • western blot; human; fig 3
In order to characterize O-GlcNAcylation-dependent phosphorylation and functional implications at a proximal site on keratin 18, Sigma-Aldrich KRT8 antibody (Sigma, C5301) was used in immunoprecipitation on human samples (fig 3) and in western blot on human samples (fig 3). J Biol Chem (2016) ncbi
mouse monoclonal (M20)
  • immunocytochemistry; human; 1:1000; loading ...; fig 5b
In order to determine the crystal structure of envoplakin's complete plakin repeat domain fold, Sigma-Aldrich KRT8 antibody (Sigma, C5301) was used in immunocytochemistry on human samples at 1:1000 (fig 5b). Nat Commun (2016) ncbi
mouse monoclonal (M20)
  • immunocytochemistry; human
In order to investigate the localization of POF1B in desmosomes and its role in human intestinal and keratinocyte cell lines, Sigma-Aldrich KRT8 antibody (Sigma Aldrich, C5301) was used in immunocytochemistry on human samples . J Invest Dermatol (2015) ncbi
mouse monoclonal (M20)
  • western blot; human
In order to describe a new in vitro model to test the effect of an aligned fibrous environment on cancer cell morphology and behavior, Sigma-Aldrich KRT8 antibody (Sigma Aldrich, C5301) was used in western blot on human samples . Acta Biomater (2014) ncbi
mouse monoclonal (M20)
  • immunohistochemistry - paraffin section; rabbit; 1:100
Sigma-Aldrich KRT8 antibody (Sigma-Aldrich, M-20) was used in immunohistochemistry - paraffin section on rabbit samples at 1:100. Biomaterials (2014) ncbi
Articles Reviewed
  1. Barros Silva J, Linn D, Steiner I, Guo G, Ali A, Pakula H, et al. Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer. Cell Rep. 2018;25:3504-3518.e6 pubmed publisher
  2. Poli V, Fagnocchi L, Fasciani A, Cherubini A, Mazzoleni S, Ferrillo S, et al. MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state. Nat Commun. 2018;9:1024 pubmed publisher
  3. Sinkala E, Sollier Christen E, Renier C, Rosàs Canyelles E, Che J, Heirich K, et al. Profiling protein expression in circulating tumour cells using microfluidic western blotting. Nat Commun. 2017;8:14622 pubmed publisher
  4. Keckesova Z, Donaher J, De Cock J, Freinkman E, Lingrell S, Bachovchin D, et al. LACTB is a tumour suppressor that modulates lipid metabolism and cell state. Nature. 2017;543:681-686 pubmed publisher
  5. Lu X, Horner J, Paul E, Shang X, Troncoso P, Deng P, et al. Effective combinatorial immunotherapy for castration-resistant prostate cancer. Nature. 2017;543:728-732 pubmed publisher
  6. Li N, Xue W, Yuan H, Dong B, Ding Y, Liu Y, et al. AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis. J Clin Invest. 2017;127:1284-1302 pubmed publisher
  7. Tao L, Xiang D, Xie Y, Bronson R, Li Z. Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours. Nat Commun. 2017;8:14431 pubmed publisher
  8. Kwon Y, Stanciu C, Philpott M, Ehrhardt C. Flow cytometry dataset for cells collected from touched surfaces. F1000Res. 2016;5:390 pubmed publisher
  9. Strietz J, Stepputtis S, Preca B, Vannier C, Kim M, Castro D, et al. ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer. Oncotarget. 2016;7:83278-83293 pubmed publisher
  10. Chiche A, Moumen M, Romagnoli M, Petit V, Lasla H, Jézéquel P, et al. p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors. Oncogene. 2017;36:2355-2365 pubmed publisher
  11. Su Q, Zhang B, Zhang L, Dang T, Rowley D, Ittmann M, et al. Jagged1 upregulation in prostate epithelial cells promotes formation of reactive stroma in the Pten null mouse model for prostate cancer. Oncogene. 2017;36:618-627 pubmed publisher
  12. Dutta A, Le Magnen C, Mitrofanova A, Ouyang X, Califano A, Abate Shen C. Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation. Science. 2016;352:1576-80 pubmed publisher
  13. Wang N, Dong B, Quan Y, Chen Q, Chu M, Xu J, et al. Regulation of Prostate Development and Benign Prostatic Hyperplasia by Autocrine Cholinergic Signaling via Maintaining the Epithelial Progenitor Cells in Proliferating Status. Stem Cell Reports. 2016;6:668-678 pubmed publisher
  14. Kakade P, Budnar S, Kalraiya R, Vaidya M. Functional Implications of O-GlcNAcylation-dependent Phosphorylation at a Proximal Site on Keratin 18. J Biol Chem. 2016;291:12003-13 pubmed publisher
  15. Fogl C, Mohammed F, Al Jassar C, Jeeves M, Knowles T, Rodriguez Zamora P, et al. Mechanism of intermediate filament recognition by plakin repeat domains revealed by envoplakin targeting of vimentin. Nat Commun. 2016;7:10827 pubmed publisher
  16. Haikala H, Klefström J, Eilers M, Wiese K. MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures. Cell Cycle. 2016;15:316-23 pubmed publisher
  17. Johnson D, Hooker E, Luong R, Yu E, He Y, Gonzalgo M, et al. Conditional Expression of the Androgen Receptor Increases Susceptibility of Bladder Cancer in Mice. PLoS ONE. 2016;11:e0148851 pubmed publisher
  18. Li Y, Adomat H, Guns E, Hojabrpour P, Duronio V, Curran T, et al. Identification of a Hematopoietic Cell Dedifferentiation-Inducing Factor. J Cell Physiol. 2016;231:1350-63 pubmed publisher
  19. Wang Z, Kim J, Teng Y, Ding H, Zhang J, Hai T, et al. Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5(+)CK8(+) epithelial cells. Oncogene. 2016;35:3555-64 pubmed publisher
  20. Abou Kheir W, Eid A, El Merahbi R, Assaf R, Daoud G. A Unique Expression of Keratin 14 in a Subset of Trophoblast Cells. PLoS ONE. 2015;10:e0139939 pubmed publisher
  21. Lee S, Johnson D, Luong R, Yu E, Cunha G, Nusse R, et al. Wnt/β-Catenin-Responsive Cells in Prostatic Development and Regeneration. Stem Cells. 2015;33:3356-67 pubmed publisher
  22. Lokody I, Francis J, Gardiner J, Erler J, Swain A. Pten Regulates Epithelial Cytodifferentiation during Prostate Development. PLoS ONE. 2015;10:e0129470 pubmed publisher
  23. Muhanna N, Mepham A, Mohamadi R, Chan H, Khan T, Akens M, et al. Nanoparticle-based sorting of circulating tumor cells by epithelial antigen expression during disease progression in an animal model. Nanomedicine. 2015;11:1613-20 pubmed publisher
  24. Ruscetti M, Quach B, Dadashian E, Mulholland D, Wu H. Tracking and Functional Characterization of Epithelial-Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis. Cancer Res. 2015;75:2749-59 pubmed publisher
  25. Wang B, Wang X, Long J, Eastham Anderson J, Firestein R, Junttila M. Castration-resistant Lgr5(+) cells are long-lived stem cells required for prostatic regeneration. Stem Cell Reports. 2015;4:768-79 pubmed publisher
  26. Lee S, Luong R, Johnson D, Cunha G, Rivina L, Gonzalgo M, et al. Androgen signaling is a confounding factor for β-catenin-mediated prostate tumorigenesis. Oncogene. 2016;35:702-14 pubmed publisher
  27. Sicoli D, Jiao X, Ju X, Velasco Velázquez M, Ertel A, Addya S, et al. CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines. Cancer Res. 2014;74:7103-14 pubmed publisher
  28. Easter S, Mitchell E, Baxley S, Desmond R, Frost A, Serra R. Wnt5a suppresses tumor formation and redirects tumor phenotype in MMTV-Wnt1 tumors. PLoS ONE. 2014;9:e113247 pubmed publisher
  29. Lu H, Clauser K, Tam W, Fröse J, Ye X, Eaton E, et al. A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat Cell Biol. 2014;16:1105-17 pubmed publisher
  30. Sackmann Sala L, Chiche A, Mosquera Garrote N, Boutillon F, Cordier C, Pourmir I, et al. Prolactin-induced prostate tumorigenesis links sustained Stat5 signaling with the amplification of basal/stem cells and emergence of putative luminal progenitors. Am J Pathol. 2014;184:3105-19 pubmed publisher
  31. Crespi A, Bertoni A, Ferrari I, Padovano V, Della Mina P, Berti E, et al. POF1B localizes to desmosomes and regulates cell adhesion in human intestinal and keratinocyte cell lines. J Invest Dermatol. 2015;135:192-201 pubmed publisher
  32. McLane J, Rivet C, Gilbert R, Ligon L. A biomaterial model of tumor stromal microenvironment promotes mesenchymal morphology but not epithelial to mesenchymal transition in epithelial cells. Acta Biomater. 2014;10:4811-4821 pubmed publisher
  33. Zhang C, Guo Y, Cui J, Zhu H, Gao W. Cytokeratin 18 is not required for morphogenesis of developing prostates but contributes to adult prostate regeneration. Biomed Res Int. 2013;2013:576472 pubmed publisher
  34. Liu Z, Yu N, Holz F, Yang F, Stanzel B. Enhancement of retinal pigment epithelial culture characteristics and subretinal space tolerance of scaffolds with 200 nm fiber topography. Biomaterials. 2014;35:2837-50 pubmed publisher
  35. Lafkas D, Rodilla V, Huyghe M, Mourao L, Kiaris H, Fre S. Notch3 marks clonogenic mammary luminal progenitor cells in vivo. J Cell Biol. 2013;203:47-56 pubmed publisher
  36. Hosokawa M, Kenmotsu H, Koh Y, Yoshino T, Yoshikawa T, Naito T, et al. Size-based isolation of circulating tumor cells in lung cancer patients using a microcavity array system. PLoS ONE. 2013;8:e67466 pubmed publisher
  37. Qi H, Zheng X, Yuan X, Pflugfelder S, Li D. Potential localization of putative stem/progenitor cells in human bulbar conjunctival epithelium. J Cell Physiol. 2010;225:180-5 pubmed publisher