This is a Validated Antibody Database (VAD) review about cow TXNIP, based on 8 published articles (read how Labome selects the articles), using TXNIP antibody in all methods. It is aimed to help Labome visitors find the most suited TXNIP antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TXNIP synonym: thioredoxin-interacting protein

Knockout validation
Invitrogen
rabbit polyclonal
  • western blot knockout validation; mouse; fig 4b
  • western blot; human; fig 4a
In order to report that NLRP3 interacts with thioredoxin-interacting protein and investigate how this interaction modulates secretion of interleukin 1 beta, Invitrogen TXNIP antibody (Invitrogen, 40-3700) was used in western blot knockout validation on mouse samples (fig 4b) and in western blot on human samples (fig 4a). Nat Immunol (2010) ncbi
Invitrogen
rabbit polyclonal
  • immunoprecipitation; mouse; fig 4
In order to show that UCP2 regulates inflammatory responses in astrocytes and contributes to depression, Invitrogen TXNIP antibody (Invitrogen, 40?C3700) was used in immunoprecipitation on mouse samples (fig 4). Redox Biol (2016) ncbi
rabbit polyclonal
  • western blot; human; fig 4
In order to elucidate how miR-373 decreases TXNIP and promotes metastasis, Invitrogen TXNIP antibody (Invitrogen, 40-4600) was used in western blot on human samples (fig 4). Oncotarget (2015) ncbi
rabbit polyclonal
  • western blot; human; 1:500; fig 1,3
In order to discuss the role of peroxisome proliferator-activated receptor gamma in anaplastic thyroid cancer and differentiated thyroid cancer, Invitrogen TXNIP antibody (Invitrogen, 403700) was used in western blot on human samples at 1:500 (fig 1,3). Mol Cancer (2014) ncbi
rabbit polyclonal
  • western blot; rat; 1:1250; fig 8
In order to assess the role of thioredoxin in myocardial injury and apoptosis using diabetic rats, Invitrogen TXNIP antibody (Invitrogen, 40-3700) was used in western blot on rat samples at 1:1250 (fig 8). Acta Biochim Biophys Sin (Shanghai) (2014) ncbi
rabbit polyclonal
  • western blot; mouse; fig 3
In order to identify candidate endogenous creatine transporter inhibitors, Invitrogen TXNIP antibody (Invitrogen, 40-3700) was used in western blot on mouse samples (fig 3). Am J Physiol Endocrinol Metab (2013) ncbi
rabbit polyclonal
  • western blot; human; fig 2
In order to test if TXNIP-TRX1 trafficking alters the function of endothelial cells exposed to reactive oxygen species, Invitrogen TXNIP antibody (Invitrogen, 403700) was used in western blot on human samples (fig 2). Arterioscler Thromb Vasc Biol (2011) ncbi
rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; fig 3
In order to demonstrate that the NLRP3 inflammasome senses mitochondrial dysfunction, Invitrogen TXNIP antibody (Invitrogen, 40-3700) was used in immunohistochemistry - frozen section on mouse samples (fig 3). Nature (2011) ncbi
rabbit polyclonal
  • western blot knockout validation; mouse; fig 4b
  • western blot; human; fig 4a
In order to report that NLRP3 interacts with thioredoxin-interacting protein and investigate how this interaction modulates secretion of interleukin 1 beta, Invitrogen TXNIP antibody (Invitrogen, 40-3700) was used in western blot knockout validation on mouse samples (fig 4b) and in western blot on human samples (fig 4a). Nat Immunol (2010) ncbi
Articles Reviewed
  1. Du R, Wu F, Lu M, Shu X, Ding J, Wu G, et al. Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression. Redox Biol. 2016;9:178-187 pubmed publisher
  2. Chen D, Dang B, Huang J, Chen M, Wu D, Xu M, et al. MiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1α-TWIST signaling axis in breast cancer. Oncotarget. 2015;6:32701-12 pubmed publisher
  3. Morrison J, Pike L, Sams S, Sharma V, Zhou Q, Severson J, et al. Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor in thyroid cancer. Mol Cancer. 2014;13:62 pubmed publisher
  4. Zhao X, Zhang Y, Li X, Wang R, Jiao X. Variations of thioredoxin system contributes to increased susceptibility to apoptosis in cardiomyocytes of type 2 diabetic rats. Acta Biochim Biophys Sin (Shanghai). 2014;46:318-29 pubmed publisher
  5. Zervou S, Ray T, Sahgal N, Sebag Montefiore L, Cross R, Medway D, et al. A role for thioredoxin-interacting protein (Txnip) in cellular creatine homeostasis. Am J Physiol Endocrinol Metab. 2013;305:E263-70 pubmed publisher
  6. World C, Spindel O, Berk B. Thioredoxin-interacting protein mediates TRX1 translocation to the plasma membrane in response to tumor necrosis factor-?: a key mechanism for vascular endothelial growth factor receptor-2 transactivation by reactive oxygen species. Arterioscler Thromb Vasc Biol. 2011;31:1890-7 pubmed publisher
  7. Zhou R, Yazdi A, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2011;469:221-5 pubmed publisher
  8. Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol. 2010;11:136-40 pubmed publisher