This is a Validated Antibody Database (VAD) review about cow PRNP, based on 7 published articles (read how Labome selects the articles), using PRNP antibody in all methods. It is aimed to help Labome visitors find the most suited PRNP antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
PRNP synonym: AltPrP; PrP; major prion protein; alternative prion protein; major scrapie-associated fibril protein 1; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); prion protein PrP; prion protein precursor PrP; prion protein variant a; prion protein variant b

Santa Cruz Biotechnology
mouse monoclonal (6D11)
  • immunohistochemistry - paraffin section; mouse; fig 5
  • western blot; mouse; fig 3
Santa Cruz Biotechnology PRNP antibody (Santa Cruz, sc-58581) was used in immunohistochemistry - paraffin section on mouse samples (fig 5) and in western blot on mouse samples (fig 3). Int J Mol Med (2016) ncbi
mouse monoclonal (6D11)
  • immunohistochemistry - paraffin section; mouse; 1:100
In order to investigate the spread of neuronal pathology, Santa Cruz Biotechnology PRNP antibody (Santa Cruz, 6D11) was used in immunohistochemistry - paraffin section on mouse samples at 1:100. Neuropathol Appl Neurobiol (2015) ncbi
mouse monoclonal (6D11)
  • other; mouse; 1:50; loading ...; fig 2a
Santa Cruz Biotechnology PRNP antibody (Santa Cruz, sc-58581) was used in other on mouse samples at 1:50 (fig 2a). Cell Death Differ (2015) ncbi
mouse monoclonal (6D11)
  • immunocytochemistry; hamsters; 1:100
  • western blot; hamsters
Santa Cruz Biotechnology PRNP antibody (SantaCruz, sc-58581) was used in immunocytochemistry on hamsters samples at 1:100 and in western blot on hamsters samples . J Mol Neurosci (2015) ncbi
Abcam
mouse monoclonal (8H4)
  • immunohistochemistry - free floating section; mouse; 1:1000; loading ...; fig 1e
Abcam PRNP antibody (Abcam, ab61409) was used in immunohistochemistry - free floating section on mouse samples at 1:1000 (fig 1e). J Neurosci (2017) ncbi
goat polyclonal
  • western blot; Human immunodeficiency virus 1; fig 1
Abcam PRNP antibody (Abcam, ab66645) was used in western blot on Human immunodeficiency virus 1 samples (fig 1). Retrovirology (2015) ncbi
BioLegend
mouse monoclonal (6D11)
  • immunocytochemistry; mouse; loading ...; fig 1d
  • western blot; mouse; 1:1000; loading ...; fig 1b
BioLegend PRNP antibody (Covance, 6D11) was used in immunocytochemistry on mouse samples (fig 1d) and in western blot on mouse samples at 1:1000 (fig 1b). J Virol (2017) ncbi
Articles Reviewed
  1. Salazar S, Gallardo C, Kaufman A, Herber C, Haas L, Robinson S, et al. Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease. J Neurosci. 2017;37:9207-9221 pubmed publisher
  2. Marshall K, Hughson A, Vascellari S, Priola S, Sakudo A, Onodera T, et al. PrP Knockout Cells Expressing Transmembrane PrP Resist Prion Infection. J Virol. 2017;91: pubmed publisher
  3. Xiao K, Zhang B, Zhang X, Wang J, Chen C, Chen L, et al. Re-infection of the prion from the scrapie‑infected cell line SMB-S15 in three strains of mice, CD1, C57BL/6 and Balb/c. Int J Mol Med. 2016;37:716-26 pubmed publisher
  4. Desimmie B, Weydert C, Schrijvers R, Vets S, Demeulemeester J, Proost P, et al. HIV-1 IN/Pol recruits LEDGF/p75 into viral particles. Retrovirology. 2015;12:16 pubmed publisher
  5. Reis R, Hennessy E, Murray C, Griffin Ã, Cunningham C. At the centre of neuronal, synaptic and axonal pathology in murine prion disease: degeneration of neuroanatomically linked thalamic and brainstem nuclei. Neuropathol Appl Neurobiol. 2015;41:780-97 pubmed publisher
  6. Woo J, Zhao X, Khan H, Penn C, Wang X, Joly Amado A, et al. Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers. Cell Death Differ. 2015;22:921-34 pubmed publisher
  7. Wang J, Zhang J, Shi Q, Zhang B, Chen C, Chen L, et al. Scrapie infection in experimental rodents and SMB-S15 cells decreased the brain endogenous levels and activities of Sirt1. J Mol Neurosci. 2015;55:1022-30 pubmed publisher