This is a Validated Antibody Database (VAD) review about cow MCL1, based on 29 published articles (read how Labome selects the articles), using MCL1 antibody in all methods. It is aimed to help Labome visitors find the most suited MCL1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
MCL1 synonym: induced myeloid leukemia cell differentiation protein Mcl-1; BCL2 family apoptosis regulator; myeloid cell leukemia sequence 1 (BCL2-related)

Cell Signaling Technology
rabbit monoclonal (D35A5)
  • other; human; loading ...; fig 4c
Cell Signaling Technology MCL1 antibody (Cell Signaling, 5453) was used in other on human samples (fig 4c). Cancer Cell (2018) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; loading ...; fig 3d
Cell Signaling Technology MCL1 antibody (Cell Signaling, 5453) was used in western blot on human samples (fig 3d). Sci Rep (2017) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; 1:1000; loading ...; fig s4a
Cell Signaling Technology MCL1 antibody (Cell Signaling, 5453) was used in western blot on human samples at 1:1000 (fig s4a). Nat Med (2017) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; 1:1000; loading ...; fig 8a
Cell Signaling Technology MCL1 antibody (cell signalling, 5453) was used in western blot on human samples at 1:1000 (fig 8a). Int J Oncol (2017) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; loading ...; fig 10a
In order to study chaperome complexes in a large set of tumor specimens, Cell Signaling Technology MCL1 antibody (Cell Signaling, 5453) was used in western blot on human samples (fig 10a). Nature (2016) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; 1:1000; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology MCL1 antibody (Cell Signaling, 5453) was used in western blot on human samples at 1:1000 (fig st1). Nat Commun (2016) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; loading ...; fig 7b
Cell Signaling Technology MCL1 antibody (Cell Signaling, 5453) was used in western blot on human samples (fig 7b). Cancer Res (2016) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; loading ...; fig s4b
Cell Signaling Technology MCL1 antibody (Cell Signaling, 5453) was used in western blot on human samples (fig s4b). Cell Death Dis (2016) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; fig 4
Cell Signaling Technology MCL1 antibody (Cell Signaling Technology, 5453) was used in western blot on human samples (fig 4). Oncotarget (2016) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; fig 7a
In order to propose that ABHD5 has a PNPLA2-independent function in regulating autophagy and tumorigenesis, Cell Signaling Technology MCL1 antibody (Cell Signaling, 5453) was used in western blot on human samples (fig 7a). Autophagy (2016) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; loading ...; fig 4b
Cell Signaling Technology MCL1 antibody (Cell Signaling, 5453) was used in western blot on human samples (fig 4b). Oncotarget (2016) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; 1:1000; fig 5
Cell Signaling Technology MCL1 antibody (Cell Signaling Tech, 5453S) was used in western blot on human samples at 1:1000 (fig 5). Oncol Lett (2016) ncbi
rabbit monoclonal (D35A5)
  • western blot; mouse; fig 2
Cell Signaling Technology MCL1 antibody (Cell Signaling Technolog, 5453) was used in western blot on mouse samples (fig 2). Cell Death Differ (2016) ncbi
rabbit monoclonal (D35A5)
  • western blot; mouse; 1:1000; fig 1e
In order to evaluate the antitumor activity of the pan-HDAC inhibitor, panobinostat, in mice, Cell Signaling Technology MCL1 antibody (Cell Signaling, 5453) was used in western blot on mouse samples at 1:1000 (fig 1e). Int J Cancer (2016) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; 1:1000; fig 1
In order to investigate the effect of Obatoclax in esophageal cancer cells, Cell Signaling Technology MCL1 antibody (Cell Signaling Tech, 5453) was used in western blot on human samples at 1:1000 (fig 1). Oncotarget (2016) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; fig 6
Cell Signaling Technology MCL1 antibody (Cell Signaling, 5453) was used in western blot on human samples (fig 6). Oncotarget (2016) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; fig 5
In order to examine the effects of brusatol on the cellular proteome in a mutant non-small cell lung cancer cell line, Cell Signaling Technology MCL1 antibody (Cell Signaling Technology, 5453) was used in western blot on human samples (fig 5). Mol Cell Proteomics (2016) ncbi
rabbit monoclonal (D35A5)
  • western blot; mouse; fig 5a
Cell Signaling Technology MCL1 antibody (Cell Signaling Technology, 5453) was used in western blot on mouse samples (fig 5a). Oncotarget (2015) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; 1:500; fig 3
In order to characterize immunogenic PEL cell death, revertion of PEL-induced immune suppression, and stimulation of DCs all triggered by capsaicin, Cell Signaling Technology MCL1 antibody (Cell Signaling Technology, 5453P) was used in western blot on human samples at 1:500 (fig 3). Oncotarget (2015) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; fig 2b
  • western blot; mouse; fig 2a
In order to utilize an E-mu-TCL1 mouse model to study miR-181b as a therapeutic agent for chronic lymphocytic leukemia, Cell Signaling Technology MCL1 antibody (Cell Signaling Technology, 5453) was used in western blot on human samples (fig 2b) and in western blot on mouse samples (fig 2a). Oncotarget (2015) ncbi
rabbit monoclonal (D35A5)
  • western blot; mouse; 1:200; fig 9
Cell Signaling Technology MCL1 antibody (Cell Signaling, 5453) was used in western blot on mouse samples at 1:200 (fig 9). PLoS ONE (2015) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; fig s7
Cell Signaling Technology MCL1 antibody (CST, 5453) was used in western blot on human samples (fig s7). Oncotarget (2015) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; fig 2a
Cell Signaling Technology MCL1 antibody (Cell Signaling, D35A5) was used in western blot on human samples (fig 2a). Cancer Lett (2015) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; fig 5
In order to elucidate how PLK1 regulates cell survival during mTORC1 hyperactivation, Cell Signaling Technology MCL1 antibody (Cell signaling, 5453) was used in western blot on human samples (fig 5). Cell Cycle (2015) ncbi
rabbit monoclonal (D35A5)
  • western blot; human
Cell Signaling Technology MCL1 antibody (Cell Signaling Technology, 5453) was used in western blot on human samples . Mol Cell Biol (2014) ncbi
rabbit monoclonal (D35A5)
  • western blot; human
Cell Signaling Technology MCL1 antibody (Cell Signaling Technologies, 5453) was used in western blot on human samples . PLoS ONE (2014) ncbi
rabbit monoclonal (D35A5)
  • western blot; mouse; fig 9
Cell Signaling Technology MCL1 antibody (Cell Signaling Technology, 5453) was used in western blot on mouse samples (fig 9). J Neurosci (2013) ncbi
rabbit monoclonal (D35A5)
  • western blot; mouse
Cell Signaling Technology MCL1 antibody (Cell Signaling, D35A5) was used in western blot on mouse samples . Mol Cancer Ther (2013) ncbi
rabbit monoclonal (D35A5)
  • western blot; human; fig 5
Cell Signaling Technology MCL1 antibody (Cell Signaling, 5453) was used in western blot on human samples (fig 5). Cell Cycle (2013) ncbi
Articles Reviewed
  1. Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  2. Sorokina I, Denisenko T, Imreh G, Tyurin Kuzmin P, Kaminskyy V, Gogvadze V, et al. Involvement of autophagy in the outcome of mitotic catastrophe. Sci Rep. 2017;7:14571 pubmed publisher
  3. Mai W, Gosa L, Daniëls V, Ta L, Tsang J, Higgins B, et al. Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma. Nat Med. 2017;23:1342-1351 pubmed publisher
  4. Yokoyama T, Kohn E, Brill E, Lee J. Apoptosis is augmented in high-grade serous ovarian cancer by the combined inhibition of Bcl-2/Bcl-xL and PARP. Int J Oncol. 2017;: pubmed publisher
  5. Rodina A, Wang T, Yan P, Gomes E, Dunphy M, Pillarsetty N, et al. The epichaperome is an integrated chaperome network that facilitates tumour survival. Nature. 2016;538:397-401 pubmed publisher
  6. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  7. Horn T, Ferretti S, Ebel N, Tam A, Ho S, Harbinski F, et al. High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells. Cancer Res. 2016;76:6950-6963 pubmed
  8. Klingbeil O, Lesche R, Gelato K, Haendler B, Lejeune P. Inhibition of BET bromodomain-dependent XIAP and FLIP expression sensitizes KRAS-mutated NSCLC to pro-apoptotic agents. Cell Death Dis. 2016;7:e2365 pubmed publisher
  9. Park S, Jo D, Jo S, Shin D, Shim S, Jo Y, et al. Inhibition of never in mitosis A (NIMA)-related kinase-4 reduces survivin expression and sensitizes cancer cells to TRAIL-induced cell death. Oncotarget. 2016;7:65957-65967 pubmed publisher
  10. Peng Y, Miao H, Wu S, Yang W, Zhang Y, Xie G, et al. ABHD5 interacts with BECN1 to regulate autophagy and tumorigenesis of colon cancer independent of PNPLA2. Autophagy. 2016;12:2167-2182 pubmed
  11. Liu H, Li W, Yu X, Gao F, Duan Z, Ma X, et al. EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis. Oncotarget. 2016;7:56338-56354 pubmed publisher
  12. Bao H, Liu P, Jiang K, Zhang X, Xie L, Wang Z, et al. Huaier polysaccharide induces apoptosis in hepatocellular carcinoma cells through p38 MAPK. Oncol Lett. 2016;12:1058-1066 pubmed
  13. Barroso González J, Auclair S, Luan S, Thomas L, Atkins K, Aslan J, et al. PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage. Cell Death Differ. 2016;23:1448-57 pubmed publisher
  14. Waldeck K, Cullinane C, Ardley K, Shortt J, Martin B, Tothill R, et al. Long term, continuous exposure to panobinostat induces terminal differentiation and long term survival in the TH-MYCN neuroblastoma mouse model. Int J Cancer. 2016;139:194-204 pubmed publisher
  15. Yu L, Wu W, Gu C, Zhong D, Zhao X, Kong Y, et al. Obatoclax impairs lysosomal function to block autophagy in cisplatin-sensitive and -resistant esophageal cancer cells. Oncotarget. 2016;7:14693-707 pubmed publisher
  16. Lub S, Maes A, Maes K, De Veirman K, De Bruyne E, Menu E, et al. Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells. Oncotarget. 2016;7:4062-76 pubmed publisher
  17. Vartanian S, Ma T, Lee J, Haverty P, Kirkpatrick D, Yu K, et al. Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis. Mol Cell Proteomics. 2016;15:1220-31 pubmed publisher
  18. Wang J, De Veirman K, De Beule N, Maes K, De Bruyne E, Van Valckenborgh E, et al. The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells. Oncotarget. 2015;6:43992-4004 pubmed publisher
  19. Granato M, Gilardini Montani M, Filardi M, Faggioni A, Cirone M. Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression. Oncotarget. 2015;6:29543-54 pubmed publisher
  20. Bresin A, Callegari E, D Abundo L, Cattani C, Bassi C, Zagatti B, et al. miR-181b as a therapeutic agent for chronic lymphocytic leukemia in the Eµ-TCL1 mouse model. Oncotarget. 2015;6:19807-18 pubmed
  21. Nagata T, Yasukawa H, Kyogoku S, Oba T, Takahashi J, Nohara S, et al. Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules. PLoS ONE. 2015;10:e0127942 pubmed publisher
  22. Gupta J, Igea A, Papaioannou M, López Casas P, Llonch E, Hidalgo M, et al. Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors. Oncotarget. 2015;6:8539-51 pubmed
  23. Lu K, Fang X, Feng L, Jiang Y, Zhou X, Liu X, et al. The STAT3 inhibitor WP1066 reverses the resistance of chronic lymphocytic leukemia cells to histone deacetylase inhibitors induced by interleukin-6. Cancer Lett. 2015;359:250-8 pubmed publisher
  24. Valianou M, Cox A, Pichette B, Hartley S, Paladhi U, Astrinidis A. Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy. Cell Cycle. 2015;14:399-407 pubmed publisher
  25. Waitkus M, Chandrasekharan U, Willard B, Tee T, Hsieh J, Przybycin C, et al. Signal integration and gene induction by a functionally distinct STAT3 phosphoform. Mol Cell Biol. 2014;34:1800-11 pubmed publisher
  26. Yoon H, Choi Y, Song J, Do I, Kang S, Ko Y, et al. Targeted inhibition of FAK, PYK2 and BCL-XL synergistically enhances apoptosis in ovarian clear cell carcinoma cell lines. PLoS ONE. 2014;9:e88587 pubmed publisher
  27. Crowther A, Gama V, Bevilacqua A, Chang S, Yuan H, Deshmukh M, et al. Tonic activation of Bax primes neural progenitors for rapid apoptosis through a mechanism preserved in medulloblastoma. J Neurosci. 2013;33:18098-108 pubmed publisher
  28. Ma T, Galimberti F, Erkmen C, Memoli V, Chinyengetere F, SEMPERE L, et al. Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancer. Mol Cancer Ther. 2013;12:1545-55 pubmed publisher
  29. Carra E, Barbieri F, Marubbi D, Pattarozzi A, Favoni R, Florio T, et al. Sorafenib selectively depletes human glioblastoma tumor-initiating cells from primary cultures. Cell Cycle. 2013;12:491-500 pubmed publisher