This is a Validated Antibody Database (VAD) review about cow MAP3K7, based on 29 published articles (read how Labome selects the articles), using MAP3K7 antibody in all methods. It is aimed to help Labome visitors find the most suited MAP3K7 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
MAP3K7 synonym: mitogen-activated protein kinase kinase kinase 7

Knockout validation
Cell Signaling Technology
rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig s1b
Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4505) was used in western blot knockout validation on human samples (fig s1b). Proc Natl Acad Sci U S A (2017) ncbi
Cell Signaling Technology
rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig 5B
Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4505) was used in western blot knockout validation on human samples (fig 5B). Biochem J (2017) ncbi
Invitrogen
rabbit monoclonal (K.846.3)
  • flow cytometry; mouse; 1:50; fig 1
In order to characterize TAK1 and modulation of skeletal muscle repair and satelline stem cell homeostasis, Invitrogen MAP3K7 antibody (Thermo Scientific, MA5-15073) was used in flow cytometry on mouse samples at 1:50 (fig 1). Nat Commun (2015) ncbi
Cell Signaling Technology
rabbit polyclonal
  • western blot; mouse; loading ...; fig 3a
Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4505) was used in western blot on mouse samples (fig 3a). EMBO J (2019) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 4c
Cell Signaling Technology MAP3K7 antibody (Cell signaling technology, 4505) was used in western blot on mouse samples at 1:1000 (fig 4c). Nat Commun (2018) ncbi
rabbit monoclonal (90C7)
  • western blot; human; loading ...; fig 3
Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4508) was used in western blot on human samples (fig 3). J Cell Biol (2018) ncbi
rabbit monoclonal (90C7)
  • western blot; human; loading ...; fig s3a
Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4508) was used in western blot on human samples (fig s3a). Theranostics (2018) ncbi
rabbit polyclonal
  • western blot; rat; 1:100; loading ...; fig 2d
Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4536) was used in western blot on rat samples at 1:100 (fig 2d). Mol Cell Endocrinol (2018) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 1c
In order to study the activation of TAK1 by interleukin-1 and TRAF6, Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4536) was used in western blot on human samples (fig 1c). Biochem J (2017) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 1c
In order to study the activation of TAK1 by interleukin-1 and TRAF6, Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4505) was used in western blot on human samples (fig 1c). Biochem J (2017) ncbi
rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig s1b
Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4505) was used in western blot knockout validation on human samples (fig s1b). Proc Natl Acad Sci U S A (2017) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 2d
Cell Signaling Technology MAP3K7 antibody (cell signalling, 4531) was used in western blot on mouse samples (fig 2d). Sci Rep (2017) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 2d
Cell Signaling Technology MAP3K7 antibody (cell signalling, 4505) was used in western blot on mouse samples (fig 2d). Sci Rep (2017) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig EV4c
Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4505) was used in western blot on mouse samples (fig EV4c). EMBO Mol Med (2017) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig EV4c
Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4531) was used in western blot on mouse samples (fig EV4c). EMBO Mol Med (2017) ncbi
rabbit monoclonal (90C7)
  • western blot; human; 1:1000; fig 4a
In order to determine the contribution of NOX4 to the development of pancreatic ductal adenocarcinoma, Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4508) was used in western blot on human samples at 1:1000 (fig 4a). Nat Commun (2017) ncbi
rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig 5B
Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4505) was used in western blot knockout validation on human samples (fig 5B). Biochem J (2017) ncbi
rabbit monoclonal (90C7)
  • western blot; pig; loading ...; fig 2a
In order to demonstrate that injury results in TAK1 activation by phosphorylation and K63-linked polyubiquitination, Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 45085) was used in western blot on pig samples (fig 2a). Arthritis Rheumatol (2017) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; fig 6a
Cell Signaling Technology MAP3K7 antibody (Cell signaling, 4531) was used in western blot on human samples at 1:1000 (fig 6a). Nat Commun (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4505) was used in western blot on human samples at 1:1000 (fig st1). Nat Commun (2016) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 4b
Cell Signaling Technology MAP3K7 antibody (CST, 4505) was used in western blot on human samples (fig 4b). Nat Microbiol (2016) ncbi
rabbit polyclonal
  • immunoprecipitation; mouse; fig 9
  • western blot; mouse; 1:1000; fig 6
Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4505) was used in immunoprecipitation on mouse samples (fig 9) and in western blot on mouse samples at 1:1000 (fig 6). Nat Commun (2016) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; fig 1
In order to characterize TAK1 and modulation of skeletal muscle repair and satelline stem cell homeostasis, Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4505) was used in western blot on mouse samples at 1:1000 (fig 1). Nat Commun (2015) ncbi
rabbit polyclonal
  • western blot; human; 1:100
Cell Signaling Technology MAP3K7 antibody (Cellular Signaling Tech, #4505) was used in western blot on human samples at 1:100. Cancer Chemother Pharmacol (2015) ncbi
rabbit polyclonal
  • western blot; human; fig s1
  • western blot; mouse; fig 1
Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4531) was used in western blot on human samples (fig s1) and in western blot on mouse samples (fig 1). Sci Rep (2015) ncbi
rabbit polyclonal
  • western blot; human
Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4505) was used in western blot on human samples . PLoS Pathog (2015) ncbi
rabbit monoclonal (90C7)
  • western blot; human
Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4508) was used in western blot on human samples . PLoS Pathog (2015) ncbi
rabbit polyclonal
  • western blot; human
Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4505) was used in western blot on human samples . Int J Mol Sci (2015) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; fig 4
In order to study TLR3-mediated pro-inflammatory cytokine production regulated by glycogen synthase kinase 3-beta ubiquitination by TRAF6, Cell Signaling Technology MAP3K7 antibody (Cell signaling, 4505) was used in western blot on mouse samples at 1:1000 (fig 4). Nat Commun (2015) ncbi
rabbit monoclonal (90C7)
  • western blot; human; fig 3
Cell Signaling Technology MAP3K7 antibody (Cell signaling, 4508) was used in western blot on human samples (fig 3). Oncotarget (2015) ncbi
rabbit polyclonal
  • western blot; human; fig 3
Cell Signaling Technology MAP3K7 antibody (Cell signaling, 4505) was used in western blot on human samples (fig 3). Oncotarget (2015) ncbi
rabbit polyclonal
  • western blot; mouse; fig 5
In order to study the function of the PHD motif of MEKK1, Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4505) was used in western blot on mouse samples (fig 5). EMBO J (2014) ncbi
rabbit monoclonal (90C7)
  • western blot; mouse; fig 5
In order to study the function of the PHD motif of MEKK1, Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4508) was used in western blot on mouse samples (fig 5). EMBO J (2014) ncbi
rabbit monoclonal (90C7)
  • western blot; human
Cell Signaling Technology MAP3K7 antibody (Cell Signaling Technology, 4508) was used in western blot on human samples . J Invest Dermatol (2015) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000
Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4531S) was used in western blot on mouse samples at 1:1000. Nat Med (2014) ncbi
rabbit polyclonal
  • western blot; human
Cell Signaling Technology MAP3K7 antibody (Cell Signaling Technology, 4531) was used in western blot on human samples . Autophagy (2014) ncbi
rabbit polyclonal
  • western blot; human; 1:100
Cell Signaling Technology MAP3K7 antibody (Cell Signaling, 4536) was used in western blot on human samples at 1:100. PLoS ONE (2013) ncbi
rabbit polyclonal
  • western blot; human
Cell Signaling Technology MAP3K7 antibody (Cell Signaling Technology, 4531) was used in western blot on human samples . Cell Death Differ (2010) ncbi
Articles Reviewed
  1. Guo M, Hartlova A, Gierlinski M, Prescott A, Castellvi J, Losa J, et al. Triggering MSR1 promotes JNK-mediated inflammation in IL-4-activated macrophages. EMBO J. 2019;38: pubmed publisher
  2. Panda S, Gekara N. The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex. Nat Commun. 2018;9:4654 pubmed publisher
  3. Yurchenko M, Skjesol A, Ryan L, Richard G, Kandasamy R, Wang N, et al. SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. J Cell Biol. 2018;217:1411-1429 pubmed publisher
  4. Zeng J, Liu W, Fan Y, He D, Li L. PrLZ increases prostate cancer docetaxel resistance by inhibiting LKB1/AMPK-mediated autophagy. Theranostics. 2018;8:109-123 pubmed publisher
  5. Hoa N, Ge L, Korach K, Levin E. Estrogen receptor beta maintains expression of KLF15 to prevent cardiac myocyte hypertrophy in female rodents. Mol Cell Endocrinol. 2018;470:240-250 pubmed publisher
  6. Zhang J, MacArtney T, Peggie M, Cohen P. Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3. Biochem J. 2017;474:2235-2248 pubmed publisher
  7. Strickson S, Emmerich C, Goh E, Zhang J, Kelsall I, MacArtney T, et al. Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling. Proc Natl Acad Sci U S A. 2017;114:E3481-E3489 pubmed publisher
  8. Cong Q, Jia H, Li P, Qiu S, Yeh J, Wang Y, et al. p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner. Sci Rep. 2017;7:45964 pubmed publisher
  9. Hammers D, Merscham Banda M, Hsiao J, ENGST S, Hartman J, Sweeney H. Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med. 2017;9:531-544 pubmed publisher
  10. Ju H, Ying H, Tian T, Ling J, Fu J, Lu Y, et al. Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma. Nat Commun. 2017;8:14437 pubmed publisher
  11. Bakshi S, Taylor J, Strickson S, McCartney T, Cohen P. Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon ?. Biochem J. 2017;474:1163-1174 pubmed publisher
  12. Ismail H, Didangelos A, Vincent T, Saklatvala J. Rapid Activation of Transforming Growth Factor ?-Activated Kinase 1 in Chondrocytes by Phosphorylation and K63 -Linked Polyubiquitination Upon Injury to Animal Articular Cartilage. Arthritis Rheumatol. 2017;69:565-575 pubmed publisher
  13. Huang T, Alvarez A, Pangeni R, Horbinski C, Lu S, Kim S, et al. A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways. Nat Commun. 2016;7:12885 pubmed publisher
  14. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  15. de Jong M, Liu Z, Chen D, Alto N. Shigella flexneri suppresses NF-?B activation by inhibiting linear ubiquitin chain ligation. Nat Microbiol. 2016;1:16084 pubmed publisher
  16. Wang P, Zhang X, Luo P, Jiang X, Zhang P, Guo J, et al. Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling. Nat Commun. 2016;7:10592 pubmed publisher
  17. Ogura Y, Hindi S, Sato S, Xiong G, Akira S, Kumar A. TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair. Nat Commun. 2015;6:10123 pubmed publisher
  18. Ying L, Chunxia Y, Wei L. Inhibition of ovarian cancer cell growth by a novel TAK1 inhibitor LYTAK1. Cancer Chemother Pharmacol. 2015;76:641-50 pubmed publisher
  19. Chen I, Hsu P, Hsu W, Chen N, Tseng P. Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation. Sci Rep. 2015;5:12300 pubmed publisher
  20. Greenfeld H, Takasaki K, Walsh M, Ersing I, Bernhardt K, Ma Y, et al. TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation. PLoS Pathog. 2015;11:e1004890 pubmed publisher
  21. Hinterseher I, Schworer C, Lillvis J, Stahl E, Erdman R, Gatalica Z, et al. Immunohistochemical analysis of the natural killer cell cytotoxicity pathway in human abdominal aortic aneurysms. Int J Mol Sci. 2015;16:11196-212 pubmed publisher
  22. Ko R, Park J, Ha H, Choi Y, Lee S. Glycogen synthase kinase 3β ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production. Nat Commun. 2015;6:6765 pubmed publisher
  23. Guo C, Hao C, Shao R, Fang B, Correa A, Hofstetter W, et al. RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer. Oncotarget. 2015;6:11114-24 pubmed
  24. Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. EMBO J. 2014;33:2581-96 pubmed publisher
  25. Wu N, Huang D, Tsou H, Lin Y, Lin W. Syk mediates IL-17-induced CCL20 expression by targeting Act1-dependent K63-linked ubiquitination of TRAF6. J Invest Dermatol. 2015;135:490-498 pubmed publisher
  26. Yu B, Chang J, Liu Y, Li J, Kevork K, Al Hezaimi K, et al. Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-?B. Nat Med. 2014;20:1009-17 pubmed publisher
  27. Zhan Z, Xie X, Cao H, Zhou X, Zhang X, Fan H, et al. Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination. Autophagy. 2014;10:257-68 pubmed publisher
  28. Datta De D, Datta A, Bhattacharjya S, Roychoudhury S. NF-kappaB mediated transcriptional repression of acid modifying hormone gastrin. PLoS ONE. 2013;8:e73409 pubmed publisher
  29. Son J, Varadarajan S, Bratton S. TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1. Cell Death Differ. 2010;17:1288-301 pubmed publisher