This is a Validated Antibody Database (VAD) review about cow KEAP1, based on 11 published articles (read how Labome selects the articles), using KEAP1 antibody in all methods. It is aimed to help Labome visitors find the most suited KEAP1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
KEAP1 synonym: kelch-like ECH-associated protein 1

Cell Signaling Technology
rabbit monoclonal (D6B12)
  • western blot; mouse; 1:1000; loading ...; fig 3i
Cell Signaling Technology KEAP1 antibody (Cell Signaling, 8047) was used in western blot on mouse samples at 1:1000 (fig 3i). Biochem Biophys Res Commun (2018) ncbi
rabbit monoclonal (D1G10)
  • western blot; human; loading ...; fig 1e
Cell Signaling Technology KEAP1 antibody (Cell signaling, D1G10) was used in western blot on human samples (fig 1e). Science (2018) ncbi
rabbit monoclonal (D6B12)
  • western blot; human; 1:1000; loading ...; fig 2f, 2h
Cell Signaling Technology KEAP1 antibody (Cell Signaling, 8047S) was used in western blot on human samples at 1:1000 (fig 2f, 2h). EMBO J (2018) ncbi
rabbit monoclonal (D6B12)
  • western blot; human; loading ...; fig 1A; 1B
Cell Signaling Technology KEAP1 antibody (Cell Signaling, 8047) was used in western blot on human samples (fig 1A; 1B). Oncotarget (2017) ncbi
rabbit monoclonal (D6B12)
  • western blot; human; 1:1000; loading ...; fig 2f
In order to identify and characterize an inhibitor of the COP9 signalosome, Cell Signaling Technology KEAP1 antibody (Cell Signaling, 8047) was used in western blot on human samples at 1:1000 (fig 2f). Nat Commun (2016) ncbi
rabbit monoclonal (D6B12)
  • western blot; rat; fig 3
Cell Signaling Technology KEAP1 antibody (Cell Signaling, 8047) was used in western blot on rat samples (fig 3). Sci Rep (2016) ncbi
rabbit monoclonal (D6B12)
  • western blot; human; fig 2a
Cell Signaling Technology KEAP1 antibody (Cell-Signaling, 8047) was used in western blot on human samples (fig 2a). Free Radic Biol Med (2015) ncbi
rabbit monoclonal (D1G10)
  • western blot; human; fig s7
Cell Signaling Technology KEAP1 antibody (Cell Signaling, 7705S) was used in western blot on human samples (fig s7). Mol Cancer Res (2015) ncbi
rabbit monoclonal (D6B12)
  • western blot; mouse; fig 6a
Cell Signaling Technology KEAP1 antibody (Cell Signaling, D6B12) was used in western blot on mouse samples (fig 6a). J Biol Chem (2015) ncbi
rabbit monoclonal (D6B12)
  • western blot; rat; 1:1000
Cell Signaling Technology KEAP1 antibody (Cell Signaling, 8047S) was used in western blot on rat samples at 1:1000. PLoS ONE (2014) ncbi
Sigma-Aldrich
rabbit polyclonal
  • western blot; rat; 1 ug/ml
In order to discuss the role of gut inflammation in chronic kidney disease, Sigma-Aldrich KEAP1 antibody (Sigma, AV34728) was used in western blot on rat samples at 1 ug/ml. Dig Dis Sci (2015) ncbi
Articles Reviewed
  1. Li C, Liu Q, Xie L. Suppressing NLRP2 expression accelerates hepatic steatosis: A mechanism involving inflammation and oxidative stress. Biochem Biophys Res Commun. 2018;507:22-29 pubmed publisher
  2. Mena E, Kjolby R, Saxton R, Werner A, Lew B, Boyle J, et al. Dimerization quality control ensures neuronal development and survival. Science. 2018;362: pubmed publisher
  3. Jena K, Kolapalli S, Mehto S, Nath P, Das B, Sahoo P, et al. TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy. EMBO J. 2018;37: pubmed publisher
  4. Cheng L, Li K, Yi N, Li X, Wang F, Xue B, et al. miRNA-141 attenuates UV-induced oxidative stress via activating Keap1-Nrf2 signaling in human retinal pigment epithelium cells and retinal ganglion cells. Oncotarget. 2017;8:13186-13194 pubmed publisher
  5. Schlierf A, Altmann E, Quancard J, Jefferson A, Assenberg R, Renatus M, et al. Targeted inhibition of the COP9 signalosome for treatment of cancer. Nat Commun. 2016;7:13166 pubmed publisher
  6. Ashino T, Yamamoto M, Numazawa S. Nrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injury. Sci Rep. 2016;6:26291 pubmed publisher
  7. Kabaria S, Choi D, Chaudhuri A, Jain M, Li H, Junn E. MicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression. Free Radic Biol Med. 2015;89:548-56 pubmed publisher
  8. Dorr C, Janik C, Weg M, Been R, Bader J, Kang R, et al. Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor. Mol Cancer Res. 2015;13:1238-47 pubmed publisher
  9. Tomasovic A, Kurrle N, Sürün D, Heidler J, Husnjak K, Poser I, et al. Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions. J Biol Chem. 2015;290:9738-52 pubmed publisher
  10. Lau W, Liu S, Pahlevan S, Yuan J, Khazaeli M, Ni Z, et al. Role of Nrf2 dysfunction in uremia-associated intestinal inflammation and epithelial barrier disruption. Dig Dis Sci. 2015;60:1215-22 pubmed publisher
  11. Padiya R, Chowdhury D, Borkar R, Srinivas R, Pal Bhadra M, Banerjee S. Garlic attenuates cardiac oxidative stress via activation of PI3K/AKT/Nrf2-Keap1 pathway in fructose-fed diabetic rat. PLoS ONE. 2014;9:e94228 pubmed publisher