This is a Validated Antibody Database (VAD) review about cow JAK2, based on 63 published articles (read how Labome selects the articles), using JAK2 antibody in all methods. It is aimed to help Labome visitors find the most suited JAK2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
JAK2 synonym: tyrosine-protein kinase JAK2; Janus kinase 2 (a protein tyrosine kinase)

Knockout validation
Cell Signaling Technology
rabbit monoclonal (D2E12)
  • western blot; mouse; loading ...; fig 2h
  • western blot knockout validation; human; fig 1f
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on mouse samples (fig 2h) and in western blot knockout validation on human samples (fig 1f). Genes Dev (2018) ncbi
Cell Signaling Technology
rabbit monoclonal (D2E12)
  • western blot knockout validation; human; loading ...; fig 5a
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot knockout validation on human samples (fig 5a). Oncotarget (2017) ncbi
Cell Signaling Technology
rabbit polyclonal
  • western blot; mouse; loading ...; fig 2b
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3771) was used in western blot on mouse samples (fig 2b). Sci Adv (2019) ncbi
rabbit monoclonal (D2E12)
  • western blot; mouse; loading ...; fig 2b
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on mouse samples (fig 2b). Sci Adv (2019) ncbi
rabbit monoclonal (D2E12)
  • western blot; mouse; loading ...; fig 3d
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on mouse samples (fig 3d). Cancer Discov (2019) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 3d
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3771) was used in western blot on mouse samples (fig 3d). Cancer Discov (2019) ncbi
rabbit monoclonal (D2E12)
  • western blot; mouse; loading ...; fig 1f
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on mouse samples (fig 1f). Cell (2018) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 1f
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3771) was used in western blot on mouse samples (fig 1f). Cell (2018) ncbi
rabbit monoclonal (C80C3)
  • western blot; mouse; loading ...; fig 5b
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3776) was used in western blot on mouse samples (fig 5b). Blood (2018) ncbi
rabbit monoclonal (D2E12)
  • western blot; mouse; loading ...; fig 5b
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on mouse samples (fig 5b). Blood (2018) ncbi
rabbit monoclonal (D2E12)
  • western blot; mouse; loading ...; fig 2h
  • western blot knockout validation; human; fig 1f
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on mouse samples (fig 2h) and in western blot knockout validation on human samples (fig 1f). Genes Dev (2018) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; loading ...; fig 1b
Cell Signaling Technology JAK2 antibody (Cell Signaling Technologies, 3230) was used in western blot on human samples (fig 1b). Oncoimmunology (2018) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 1d
Cell Signaling Technology JAK2 antibody (Cell Signaling Technologies, 3771) was used in western blot on human samples at 1:1000 (fig 1d). Nat Commun (2018) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; 1:1000; loading ...; fig 1d
Cell Signaling Technology JAK2 antibody (Cell Signaling Technologies, 3230) was used in western blot on human samples at 1:1000 (fig 1d). Nat Commun (2018) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig 3b
Cell Signaling Technology JAK2 antibody (Cell Signalling Technologies, 3771) was used in western blot on human samples at 1:1000 (fig 3b). Nat Commun (2018) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; 1:1000; loading ...; fig 3b
Cell Signaling Technology JAK2 antibody (Cell Signalling Technologies, 3230) was used in western blot on human samples at 1:1000 (fig 3b). Nat Commun (2018) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; fig 4a
Cell Signaling Technology JAK2 antibody (CST, 3230) was used in western blot on human samples (fig 4a). PLoS Pathog (2018) ncbi
rabbit monoclonal (C80C3)
  • western blot; human; fig 4a
Cell Signaling Technology JAK2 antibody (CST, 3776) was used in western blot on human samples (fig 4a). PLoS Pathog (2018) ncbi
rabbit monoclonal (D2E12)
  • western blot; mouse; loading ...; fig 6d
Cell Signaling Technology JAK2 antibody (Cell Signaling, D2E12) was used in western blot on mouse samples (fig 6d). Oncogene (2018) ncbi
rabbit monoclonal (D2E12)
  • other; human; loading ...; fig 4c
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in other on human samples (fig 4c). Cancer Cell (2018) ncbi
rabbit monoclonal (D2E12)
  • western blot; mouse; 1:1000; loading ...; fig 6c
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on mouse samples at 1:1000 (fig 6c). Proc Natl Acad Sci U S A (2018) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 6c
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3771) was used in western blot on mouse samples at 1:1000 (fig 6c). Proc Natl Acad Sci U S A (2018) ncbi
rabbit monoclonal (D15E2)
  • western blot; human; loading ...; fig 2a
Cell Signaling Technology JAK2 antibody (Cell Signaling, 4406) was used in western blot on human samples (fig 2a). PLoS ONE (2018) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; loading ...; fig 2a
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on human samples (fig 2a). PLoS ONE (2018) ncbi
rabbit monoclonal (D2E12)
  • western blot; mouse; 1:1000; fig 2h
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on mouse samples at 1:1000 (fig 2h). J Cell Sci (2018) ncbi
rabbit monoclonal (D2E12)
  • western blot knockout validation; human; loading ...; fig 5a
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot knockout validation on human samples (fig 5a). Oncotarget (2017) ncbi
rabbit monoclonal (C80C3)
  • western blot; mouse; loading ...; fig 5b
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3776) was used in western blot on mouse samples (fig 5b). J Nutr Biochem (2017) ncbi
rabbit monoclonal (D2E12)
  • western blot; mouse; 1:1000; loading ...; fig 6c
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on mouse samples at 1:1000 (fig 6c). Int J Mol Med (2017) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 6c
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3771) was used in western blot on mouse samples at 1:1000 (fig 6c). Int J Mol Med (2017) ncbi
rabbit monoclonal (D4A8)
  • western blot; mouse; 1:1000; fig 9b
In order to explore the roles of activated portal fibroblasts and myofibroblasts in the pathogenesis of liver fibrosis induced by bile duct ligation, Cell Signaling Technology JAK2 antibody (Cell Signaling, 8082) was used in western blot on mouse samples at 1:1000 (fig 9b). J Clin Invest (2017) ncbi
rabbit monoclonal (D2E12)
  • western blot; mouse; 1:1000; fig 9b
In order to explore the roles of activated portal fibroblasts and myofibroblasts in the pathogenesis of liver fibrosis induced by bile duct ligation, Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on mouse samples at 1:1000 (fig 9b). J Clin Invest (2017) ncbi
rabbit monoclonal (D4A8)
  • western blot; human; 1:200; loading ...; fig 3a
Cell Signaling Technology JAK2 antibody (CST, 8082) was used in western blot on human samples at 1:200 (fig 3a). Oncotarget (2017) ncbi
rabbit monoclonal (D15E2)
  • western blot; human; loading ...; fig s9c
Cell Signaling Technology JAK2 antibody (Cell Signaling, 4406) was used in western blot on human samples (fig s9c). Arterioscler Thromb Vasc Biol (2017) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; loading ...; fig s9c
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on human samples (fig s9c). Arterioscler Thromb Vasc Biol (2017) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; loading ...; fig 3e
Cell Signaling Technology JAK2 antibody (Cell signaling, 3230) was used in western blot on human samples (fig 3e). Nat Commun (2017) ncbi
rabbit monoclonal (D15E2)
  • western blot; mouse; loading ...; fig 4d
Cell Signaling Technology JAK2 antibody (Cell signaling, 4406) was used in western blot on mouse samples (fig 4d). Mol Biol Cell (2017) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; 1:1000; loading ...; fig 6b
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on human samples at 1:1000 (fig 6b). Nat Commun (2016) ncbi
rabbit monoclonal (D4A8)
  • western blot; mouse; loading ...; fig s8
In order to find that that vascular endothelial growth factor 165b prevents activation of vascular endothelial growth factor receptor 1-STAT3 signaling by vascular endothelial growth factor 165a, Cell Signaling Technology JAK2 antibody (Cell Signaling, 8082) was used in western blot on mouse samples (fig s8). Circ Res (2017) ncbi
rabbit monoclonal (D2E12)
  • immunoprecipitation; mouse; loading ...; fig 4
  • western blot; mouse; loading ...; fig 4
In order to study mouse models of dilated cardiomyopathy to study calcium signaling, Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in immunoprecipitation on mouse samples (fig 4) and in western blot on mouse samples (fig 4). PLoS ONE (2016) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 4
In order to study mouse models of dilated cardiomyopathy to study calcium signaling, Cell Signaling Technology JAK2 antibody (Cell Signaling, 3771) was used in western blot on mouse samples (fig 4). PLoS ONE (2016) ncbi
rabbit monoclonal (D2E12)
  • western blot; cow; 1:1000; loading ...; tbl 2
In order to study the transport of cholesterol and phospholipids in mammary epithelial cells, Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on cow samples at 1:1000 (tbl 2). Mol Cell Endocrinol (2017) ncbi
rabbit monoclonal (D2E12)
  • western blot; mouse; fig 6c
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, D2E12) was used in western blot on mouse samples (fig 6c). J Exp Med (2016) ncbi
rabbit monoclonal (D2E12)
  • western blot; mouse; loading ...; fig 6e
In order to explore the role of estrogen-induced deregulated myelopoiesis in cancer, Cell Signaling Technology JAK2 antibody (Cell signaling, D2E12) was used in western blot on mouse samples (fig 6e). Cancer Discov (2017) ncbi
rabbit monoclonal (C80C3)
  • western blot; human; loading ...; fig 4
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, C80C3) was used in western blot on human samples (fig 4). Oncotarget (2016) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; loading ...; fig 4
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, D2E12) was used in western blot on human samples (fig 4). Oncotarget (2016) ncbi
rabbit polyclonal
  • western blot; human; fig 2a
  • western blot; mouse; fig 5f
In order to report that TrkC contributes to tumorigenicity, metastasis, and self-renewal traits of metastatic breast cancer, Cell Signaling Technology JAK2 antibody (Cell Signaling, 3771) was used in western blot on human samples (fig 2a) and in western blot on mouse samples (fig 5f). Sci Rep (2016) ncbi
rabbit monoclonal (C80C3)
  • western blot; rat; fig 2
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3776) was used in western blot on rat samples (fig 2). Int J Mol Med (2016) ncbi
rabbit monoclonal (D2E12)
  • western blot; rat; fig 2
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on rat samples (fig 2). Int J Mol Med (2016) ncbi
rabbit monoclonal (D4A8)
  • western blot; mouse; fig 4
Cell Signaling Technology JAK2 antibody (Cell Signaling, 8082S) was used in western blot on mouse samples (fig 4). Sci Rep (2016) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; 1:1000; fig 3
In order to analyze the mediation of the STAT3 signaling pathway by sinomenine that inhibits A549 human lung cancer cell invasion, Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on human samples at 1:1000 (fig 3). Oncol Lett (2016) ncbi
rabbit monoclonal (D2E12)
  • western blot; mouse; fig 1c
Cell Signaling Technology JAK2 antibody (CST, 3230) was used in western blot on mouse samples (fig 1c). J Exp Med (2016) ncbi
rabbit polyclonal
  • western blot; mouse; 1:500; fig 7D
In order to study the amelioration of neuropathic pain by down-regulating spinal IL-1-beta via suppressing JAK2-STAT3 signaling and astroglial NALP1 inflammasome by curcumin, Cell Signaling Technology JAK2 antibody (Cell Signaling, 3771) was used in western blot on mouse samples at 1:500 (fig 7D). Sci Rep (2016) ncbi
rabbit monoclonal (D2E12)
  • western blot; mouse; 1:1000; fig 7D
In order to study the amelioration of neuropathic pain by down-regulating spinal IL-1-beta via suppressing JAK2-STAT3 signaling and astroglial NALP1 inflammasome by curcumin, Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on mouse samples at 1:1000 (fig 7D). Sci Rep (2016) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; 1:1000; fig 5b
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on human samples at 1:1000 (fig 5b). J Biol Chem (2016) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 5c
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3771) was used in western blot on human samples (fig 5c). Carcinogenesis (2016) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; loading ...; fig 5c
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on human samples (fig 5c). Carcinogenesis (2016) ncbi
rabbit monoclonal (D2E12)
  • western blot; mouse; 1:500; loading ...; fig S6c
In order to demonstrate that Ndfip1/Ndfip2 regulate cross talk between T-cell receptor and cytokine signaling pathways, Cell Signaling Technology JAK2 antibody (Cell Signaling Technologies, D2E12) was used in western blot on mouse samples at 1:500 (fig S6c). Nat Commun (2016) ncbi
rabbit monoclonal (D2E12)
  • western blot; mouse; loading ...; fig 5b
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on mouse samples (fig 5b). PLoS ONE (2016) ncbi
rabbit polyclonal
  • immunohistochemistry; mouse; loading ...; fig 5c
  • western blot; scFv; loading ...; fig 5b
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3771) was used in immunohistochemistry on mouse samples (fig 5c) and in western blot on scFv samples (fig 5b). PLoS ONE (2016) ncbi
rabbit monoclonal (D4A8)
  • western blot; human; fig 5
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, 8082) was used in western blot on human samples (fig 5). BMC Cancer (2016) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; fig 5
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, 3230) was used in western blot on human samples (fig 5). BMC Cancer (2016) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; fig 5
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, 3230) was used in western blot on human samples (fig 5). Sci Rep (2016) ncbi
rabbit monoclonal (C80C3)
  • western blot; mouse; fig s5
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3776) was used in western blot on mouse samples (fig s5). Oncotarget (2016) ncbi
rabbit polyclonal
  • western blot; human; fig 1c
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, 3771) was used in western blot on human samples (fig 1c). J Biol Chem (2016) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; fig 1c
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, 3230) was used in western blot on human samples (fig 1c). J Biol Chem (2016) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; loading ...; fig 5d
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on human samples (fig 5d). Oncogene (2016) ncbi
rabbit monoclonal (D2E12)
  • immunohistochemistry; human; 1:20; tbl 2
In order to evaluate the reliance on EBV or NF-kappaB signaling instead of B-cell receptor signaling in regards to complete phenotypic characterization of PTLD, Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in immunohistochemistry on human samples at 1:20 (tbl 2). Hematol Oncol (2017) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; 1:1000; fig 5
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, 3230) was used in western blot on human samples at 1:1000 (fig 5). Mol Med Rep (2016) ncbi
rabbit monoclonal (D4A8)
  • western blot; human; 1:1000; fig 5
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, 8082) was used in western blot on human samples at 1:1000 (fig 5). Mol Med Rep (2016) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; 1:1000; loading ...; fig 4a
In order to present the role of 4-Methoxydalbergione in human osteosarcoma cells in vitro and in vivo xenograft model, Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on human samples at 1:1000 (fig 4a). Oncotarget (2016) ncbi
rabbit monoclonal (D15E2)
  • western blot; human; 1:1000; loading ...; fig 4a
In order to present the role of 4-Methoxydalbergione in human osteosarcoma cells in vitro and in vivo xenograft model, Cell Signaling Technology JAK2 antibody (Cell Signaling, 4406) was used in western blot on human samples at 1:1000 (fig 4a). Oncotarget (2016) ncbi
rabbit polyclonal
  • western blot; human; fig e2
In order to study triple-negative breast cancer and BET bromodomain inhibitor response and resistance, Cell Signaling Technology JAK2 antibody (Cell Signaling, 3771) was used in western blot on human samples (fig e2). Nature (2016) ncbi
rabbit monoclonal (C80C3)
  • western blot; human; fig 3
In order to assess the effects of curcumin on lung cancer stem-like cells, Cell Signaling Technology JAK2 antibody (cell signalling technology, 3776) was used in western blot on human samples (fig 3). Oncol Rep (2015) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; fig 3
In order to assess the effects of curcumin on lung cancer stem-like cells, Cell Signaling Technology JAK2 antibody (cell signalling technology, 3230) was used in western blot on human samples (fig 3). Oncol Rep (2015) ncbi
rabbit monoclonal (D2E12)
  • western blot; mouse; 1:1000; fig 7
In order to determine the correlation between neuronal caMKII-CREB and astroglial JAK2-STAT3 cascades in mice and how spinal IL-33/ST2 signaling contributes to neuropathic pain, Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, 3230) was used in western blot on mouse samples at 1:1000 (fig 7). Anesthesiology (2015) ncbi
rabbit polyclonal
  • western blot; mouse; 1:500; fig 7
In order to determine the correlation between neuronal caMKII-CREB and astroglial JAK2-STAT3 cascades in mice and how spinal IL-33/ST2 signaling contributes to neuropathic pain, Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, 3771) was used in western blot on mouse samples at 1:500 (fig 7). Anesthesiology (2015) ncbi
rabbit monoclonal (D2E12)
  • immunohistochemistry - frozen section; human
  • immunocytochemistry; human; fig 6
  • western blot; human; fig 2d
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, D2E12) was used in immunohistochemistry - frozen section on human samples , in immunocytochemistry on human samples (fig 6) and in western blot on human samples (fig 2d). Leukemia (2016) ncbi
rabbit monoclonal (C80C3)
  • western blot; human; fig 2d
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, C80C3) was used in western blot on human samples (fig 2d). Leukemia (2016) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; fig 4
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, 3230) was used in western blot on human samples (fig 4). Oncotarget (2015) ncbi
rabbit monoclonal (D2E12)
  • immunohistochemistry - paraffin section; human; 1:800
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, 3230) was used in immunohistochemistry - paraffin section on human samples at 1:800. APMIS (2015) ncbi
rabbit monoclonal (D15E2)
  • western blot; human; 1:1000; fig 5
Cell Signaling Technology JAK2 antibody (Cell signaling, 4406P) was used in western blot on human samples at 1:1000 (fig 5). Oncotarget (2015) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; fig s1
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on human samples (fig s1). Cell Death Dis (2015) ncbi
rabbit monoclonal (D2E12)
  • proximity ligation assay; mouse; 1:100; loading ...; fig 6h
  • western blot; human; 1:1000; loading ...; fig 6f
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, 3230) was used in proximity ligation assay on mouse samples at 1:100 (fig 6h) and in western blot on human samples at 1:1000 (fig 6f). Nat Commun (2015) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; fig 7c
Cell Signaling Technology JAK2 antibody (Cell Signaling, D2E12) was used in western blot on human samples (fig 7c). J Immunol (2015) ncbi
rabbit polyclonal
  • western blot; rat
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, 3771) was used in western blot on rat samples . PLoS ONE (2014) ncbi
rabbit monoclonal (D2E12)
  • western blot; rat
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, 3230) was used in western blot on rat samples . PLoS ONE (2014) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; loading ...; fig 6a
Cell Signaling Technology JAK2 antibody (Cell Signaling, D2E12) was used in western blot on human samples (fig 6a). Mol Cell Biol (2015) ncbi
rabbit monoclonal (C80C3)
  • western blot; mouse
Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, 3776) was used in western blot on mouse samples . J Agric Food Chem (2014) ncbi
rabbit monoclonal (D2E12)
  • western blot; human; fig 5
Cell Signaling Technology JAK2 antibody (Cell Signaling, 3230) was used in western blot on human samples (fig 5). J Biol Chem (2014) ncbi
rabbit monoclonal (D2E12)
  • western blot; rat
In order to investigate the role of ANGII in the regulation of latent and active MMP-2 in rat heart, Cell Signaling Technology JAK2 antibody (Cell Signalling, 3230) was used in western blot on rat samples . Basic Res Cardiol (2014) ncbi
rabbit monoclonal (D4A8)
  • western blot; rat
In order to investigate the role of ANGII in the regulation of latent and active MMP-2 in rat heart, Cell Signaling Technology JAK2 antibody (Cell Signalling, 8082) was used in western blot on rat samples . Basic Res Cardiol (2014) ncbi
rabbit monoclonal (D2E12)
  • western blot; human
In order to show that uPAR regulates nasopharyngeal carcinoma NPC progression, Cell Signaling Technology JAK2 antibody (Cell Signaling Technology, 3230) was used in western blot on human samples . Cell Cycle (2014) ncbi
Articles Reviewed
  1. Huang X, Feng Z, Jiang Y, Li J, Xiang Q, Guo S, et al. VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages. Sci Adv. 2019;5:eaau7426 pubmed publisher
  2. Biffi G, Oni T, Spielman B, Hao Y, Elyada E, Park Y, et al. IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. Cancer Discov. 2019;9:282-301 pubmed publisher
  3. Xu X, Xu J, Wu J, Hu Y, Han Y, Gu Y, et al. Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response. Cell. 2018;175:1336-1351.e17 pubmed publisher
  4. Chorzalska A, Morgan J, Ahsan N, Treaba D, Olszewski A, Petersen M, et al. Bone marrow-specific loss of ABI1 induces myeloproliferative neoplasm with features resembling human myelofibrosis. Blood. 2018;: pubmed publisher
  5. Kim S, Knight D, Jones L, Vervoort S, Ng A, Seymour J, et al. JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias. Genes Dev. 2018;32:849-864 pubmed publisher
  6. Luo N, Formisano L, Gonzalez Ericsson P, Sanchez V, Dean P, Opalenik S, et al. Melanoma response to anti-PD-L1 immunotherapy requires JAK1 signaling, but not JAK2. Oncoimmunology. 2018;7:e1438106 pubmed publisher
  7. Ng S, Yoshida N, Christie A, Ghandi M, Dharia N, Dempster J, et al. Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models. Nat Commun. 2018;9:2024 pubmed publisher
  8. Sevin M, Kubovcakova L, Pernet N, Causse S, Vitte F, Villeval J, et al. HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis. Nat Commun. 2018;9:1431 pubmed publisher
  9. Morgan E, Wasson C, Hanson L, Kealy D, Pentland I, McGuire V, et al. STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle. PLoS Pathog. 2018;14:e1006975 pubmed publisher
  10. Xi J, Huang Q, Wang L, Ma X, Deng Q, Kumar M, et al. miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy. Oncogene. 2018;37:3151-3165 pubmed publisher
  11. Ng P, Li J, Jeong K, Shao S, Chen H, Tsang Y, et al. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018;33:450-462.e10 pubmed publisher
  12. Giurisato E, Xu Q, Lonardi S, Telfer B, Russo I, Pearson A, et al. Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition. Proc Natl Acad Sci U S A. 2018;115:E2801-E2810 pubmed publisher
  13. Kulling P, Olson K, Hamele C, Toro M, Tan S, Feith D, et al. Dysregulation of the IFN-?-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia. PLoS ONE. 2018;13:e0193429 pubmed publisher
  14. Xu S, Zhou Z, Li H, Liu Z, Pan X, Wang F, et al. BMSCs ameliorate septic coagulopathy by suppressing inflammation in cecal ligation and puncture-induced sepsis. J Cell Sci. 2018;131: pubmed publisher
  15. Shen T, Chen Z, Zhao Z, Wu J. Genetic defects of the IRF1-mediated major histocompatibility complex class I antigen presentation pathway occur prevalently in the JAK2 gene in non-small cell lung cancer. Oncotarget. 2017;8:60975-60986 pubmed publisher
  16. Bagarolli R, Tobar N, Oliveira A, Araújo T, Carvalho B, Rocha G, et al. Probiotics modulate gut microbiota and improve insulin sensitivity in DIO mice. J Nutr Biochem. 2017;50:16-25 pubmed publisher
  17. Yu J, Wu H, Liu Z, Zhu Q, Shan C, Zhang K. Advanced glycation end products induce the apoptosis of and inflammation in mouse podocytes through CXCL9-mediated JAK2/STAT3 pathway activation. Int J Mol Med. 2017;40:1185-1193 pubmed publisher
  18. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, et al. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 2017;127:1254-1270 pubmed publisher
  19. Basu R, Wu S, Kopchick J. Targeting growth hormone receptor in human melanoma cells attenuates tumor progression and epithelial mesenchymal transition via suppression of multiple oncogenic pathways. Oncotarget. 2017;8:21579-21598 pubmed publisher
  20. He Y, Wang X, Zhang J, Liu Z, Pan W, Shen Y, et al. Association of Serum HMGB2 Levels With In-Stent Restenosis: HMGB2 Promotes Neointimal Hyperplasia in Mice With Femoral Artery Injury and Proliferation and Migration of VSMCs. Arterioscler Thromb Vasc Biol. 2017;37:717-729 pubmed publisher
  21. Cayrol F, Praditsuktavorn P, Fernando T, Kwiatkowski N, Marullo R, Calvo Vidal M, et al. THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors. Nat Commun. 2017;8:14290 pubmed publisher
  22. Chaudhari A, Gupta R, Patel S, Velingkaar N, Kondratov R. Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylation. Mol Biol Cell. 2017;28:834-842 pubmed publisher
  23. Eletto D, Burns S, Angulo I, Plagnol V, Gilmour K, Henriquez F, et al. Biallelic JAK1 mutations in immunodeficient patient with mycobacterial infection. Nat Commun. 2016;7:13992 pubmed publisher
  24. Ganta V, Choi M, Kutateladze A, Annex B. VEGF165b Modulates Endothelial VEGFR1-STAT3 Signaling Pathway and Angiogenesis in Human and Experimental Peripheral Arterial Disease. Circ Res. 2017;120:282-295 pubmed publisher
  25. Ramratnam M, Salama G, Sharma R, Wang D, Smith S, Banerjee S, et al. Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization. PLoS ONE. 2016;11:e0167681 pubmed publisher
  26. Ontsouka C, Huang X, Aliyev E, Albrecht C. In vitro characterization and endocrine regulation of cholesterol and phospholipid transport in the mammary gland. Mol Cell Endocrinol. 2017;439:35-45 pubmed publisher
  27. Textor A, Schmidt K, Kloetzel P, Weißbrich B, Perez C, Charo J, et al. Preventing tumor escape by targeting a post-proteasomal trimming independent epitope. J Exp Med. 2016;213:2333-2348 pubmed
  28. Svoronos N, Perales Puchalt A, Allegrezza M, Rutkowski M, Payne K, Tesone A, et al. Tumor Cell-Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells. Cancer Discov. 2017;7:72-85 pubmed publisher
  29. Ma Y, Chen L, Xie G, Zhou Y, Yue C, Yuan X, et al. Elevated level of interleukin-35 in colorectal cancer induces conversion of T cells into iTr35 by activating STAT1/STAT3. Oncotarget. 2016;7:73003-73015 pubmed publisher
  30. Kim M, Jeong J, Seo J, Kim H, Kim S, Jin W. Dysregulated JAK2 expression by TrkC promotes metastasis potential, and EMT program of metastatic breast cancer. Sci Rep. 2016;6:33899 pubmed publisher
  31. Zhang Y, Hu S, Chen Y, Guo M, Wang S. Hepatocyte growth factor inhibits hypoxia/reoxygenation-induced activation of xanthine oxidase in endothelial cells through the JAK2 signaling pathway. Int J Mol Med. 2016;38:1055-62 pubmed publisher
  32. Guo L, Costanzo Garvey D, Smith D, Zavorka M, Venable Kang M, MacDonald R, et al. Cell non-autonomous regulation of hepatic IGF-1 and neonatal growth by Kinase Suppressor of Ras 2 (KSR2). Sci Rep. 2016;6:32093 pubmed publisher
  33. Jiang S, Gao Y, Hou W, Liu R, Qi X, Xu X, et al. Sinomenine inhibits A549 human lung cancer cell invasion by mediating the STAT3 signaling pathway. Oncol Lett. 2016;12:1380-1386 pubmed
  34. Sashida G, Wang C, Tomioka T, Oshima M, Aoyama K, Kanai A, et al. The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition. J Exp Med. 2016;213:1459-77 pubmed publisher
  35. Liu S, Li Q, Zhang M, Mao Ying Q, Hu L, Wu G, et al. Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1β via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling. Sci Rep. 2016;6:28956 pubmed publisher
  36. Beck D, Zobel J, Barber R, Evans S, Lezina L, Allchin R, et al. Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma. J Biol Chem. 2016;291:16686-98 pubmed publisher
  37. Sun F, Zhang Z, Tan E, Lim Z, Li Y, Wang X, et al. Icaritin suppresses development of neuroendocrine differentiation of prostate cancer through inhibition of IL-6/STAT3 and Aurora kinase A pathways in TRAMP mice. Carcinogenesis. 2016;37:701-711 pubmed publisher
  38. O Leary C, Riling C, Spruce L, Ding H, Kumar S, Deng G, et al. Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells. Nat Commun. 2016;7:11226 pubmed publisher
  39. Li J, Chen K, Li S, Liu T, Wang F, Xia Y, et al. Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis. PLoS ONE. 2016;11:e0152570 pubmed publisher
  40. Huang J, Yao C, Chuang S, Yeh C, Lee L, Chen R, et al. Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction. BMC Cancer. 2016;16:245 pubmed publisher
  41. Afsar T, Trembley J, Salomon C, Razak S, Khan M, Ahmed K. Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways. Sci Rep. 2016;6:23077 pubmed publisher
  42. Krause C, Popp O, Thirunarayanan N, Dittmar G, Lipp M, Müller G. MicroRNA-34a promotes genomic instability by a broad suppression of genome maintenance mechanisms downstream of the oncogene KSHV-vGPCR. Oncotarget. 2016;7:10414-32 pubmed publisher
  43. Heir P, Srikumar T, Bikopoulos G, Bunda S, Poon B, Lee J, et al. Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling. J Biol Chem. 2016;291:7357-72 pubmed publisher
  44. Teng Y, Pi W, Wang Y, Cowell J. WASF3 provides the conduit to facilitate invasion and metastasis in breast cancer cells through HER2/HER3 signaling. Oncogene. 2016;35:4633-40 pubmed publisher
  45. Menter T, Dickenmann M, Juskevicius D, Steiger J, Dirnhofer S, Tzankov A. Comprehensive phenotypic characterization of PTLD reveals potential reliance on EBV or NF-κB signalling instead of B-cell receptor signalling. Hematol Oncol. 2017;35:187-197 pubmed publisher
  46. Cui L, Gao B, Cao Z, Chen X, Zhang S, Zhang W. Downregulation of B7-H4 in the MHCC97-H hepatocellular carcinoma cell line by arsenic trioxide. Mol Med Rep. 2016;13:2032-8 pubmed publisher
  47. Park K, Yun H, Quang T, Oh H, Lee D, Auh Q, et al. 4-Methoxydalbergione suppresses growth and induces apoptosis in human osteosarcoma cells in vitro and in vivo xenograft model through down-regulation of the JAK2/STAT3 pathway. Oncotarget. 2016;7:6960-71 pubmed publisher
  48. Shu S, Lin C, He H, Witwicki R, Tabassum D, Roberts J, et al. Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer. Nature. 2016;529:413-417 pubmed publisher
  49. Wu L, Guo L, Liang Y, Liu X, Jiang L, Wang L. Curcumin suppresses stem-like traits of lung cancer cells via inhibiting the JAK2/STAT3 signaling pathway. Oncol Rep. 2015;34:3311-7 pubmed publisher
  50. Liu S, Mi W, Li Q, Zhang M, Han P, Hu S, et al. Spinal IL-33/ST2 Signaling Contributes to Neuropathic Pain via Neuronal CaMKII-CREB and Astroglial JAK2-STAT3 Cascades in Mice. Anesthesiology. 2015;123:1154-69 pubmed publisher
  51. Roncero A, López Nieva P, Cobos Fernández M, Villa Morales M, González Sánchez L, López Lorenzo J, et al. Contribution of JAK2 mutations to T-cell lymphoblastic lymphoma development. Leukemia. 2016;30:94-103 pubmed publisher
  52. Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, et al. Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline. Oncotarget. 2015;6:14796-813 pubmed
  53. Andreasen S, Therkildsen M, Grauslund M, Friis Hansen L, Wessel I, Homøe P. Activation of the interleukin-6/Janus kinase/STAT3 pathway in pleomorphic adenoma of the parotid gland. APMIS. 2015;123:706-15 pubmed publisher
  54. Zucha M, Wu A, Lee W, Wang L, Lin W, Yuan C, et al. Bruton's tyrosine kinase (Btk) inhibitor ibrutinib suppresses stem-like traits in ovarian cancer. Oncotarget. 2015;6:13255-68 pubmed
  55. Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed publisher
  56. Salvucci O, Ohnuki H, Maric D, Hou X, Li X, Yoon S, et al. EphrinB2 controls vessel pruning through STAT1-JNK3 signalling. Nat Commun. 2015;6:6576 pubmed publisher
  57. Mirenda M, Toffali L, Montresor A, Scardoni G, Sorio C, Laudanna C. Protein tyrosine phosphatase receptor type γ is a JAK phosphatase and negatively regulates leukocyte integrin activation. J Immunol. 2015;194:2168-79 pubmed publisher
  58. Matsuo R, Morihara H, Mohri T, Murasawa S, Takewaki K, Nakayama H, et al. The inhibition of N-glycosylation of glycoprotein 130 molecule abolishes STAT3 activation by IL-6 family cytokines in cultured cardiac myocytes. PLoS ONE. 2014;9:e111097 pubmed publisher
  59. Jay J, Hammer A, Nestor Kalinoski A, Diakonova M. JAK2 tyrosine kinase phosphorylates and is negatively regulated by centrosomal protein Ninein. Mol Cell Biol. 2015;35:111-31 pubmed publisher
  60. Huang S, Lee C, Wang H, Chang Y, Lin C, Chen C, et al. 6-Dehydrogingerdione restrains lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages. J Agric Food Chem. 2014;62:9171-9 pubmed publisher
  61. Tao W, Leng X, Chakraborty S, Ma H, Arlinghaus R. c-Abl activates janus kinase 2 in normal hematopoietic cells. J Biol Chem. 2014;289:21463-72 pubmed publisher
  62. Kopaliani I, Martin M, Zatschler B, Bortlik K, Müller B, Deussen A. Cell-specific and endothelium-dependent regulations of matrix metalloproteinase-2 in rat aorta. Basic Res Cardiol. 2014;109:419 pubmed publisher
  63. Bao Y, Cao X, Luo D, Sun R, Peng L, Wang L, et al. Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis. Cell Cycle. 2014;13:1958-69 pubmed publisher