This is a Validated Antibody Database (VAD) review about cow IKBKB, based on 25 published articles (read how Labome selects the articles), using IKBKB antibody in all methods. It is aimed to help Labome visitors find the most suited IKBKB antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
IKBKB synonym: inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; IKK-beta; IKK2; NFKBIKB; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa B kinase beta subunit; nuclear factor NF-kappa-B inhibitor kinase beta

Invitrogen
rabbit monoclonal (J.10.3)
  • western blot; human
In order to report that induction of senescence and immune surveillance limit melanoma growth, Invitrogen IKBKB antibody (Pierce Biotechnology, MA5-14857) was used in western blot on human samples . EMBO Mol Med (2013) ncbi
Cell Signaling Technology
rabbit monoclonal (C84E11)
  • western blot; mouse; 1:1000; loading ...; fig 4c
Cell Signaling Technology IKBKB antibody (Cell signaling technology, 2078) was used in western blot on mouse samples at 1:1000 (fig 4c). Nat Commun (2018) ncbi
rabbit monoclonal (C84E11)
  • western blot; mouse; 1:1000; loading ...; fig 3g
Cell Signaling Technology IKBKB antibody (Cell Signaling, 2078) was used in western blot on mouse samples at 1:1000 (fig 3g). Biochem Biophys Res Commun (2018) ncbi
rabbit polyclonal
  • immunoprecipitation; human; loading ...; fig 3e
Cell Signaling Technology IKBKB antibody (Cell Signaling Technology., 2678) was used in immunoprecipitation on human samples (fig 3e). Sci Adv (2018) ncbi
rabbit monoclonal (C84E11)
  • western blot; mouse; fig 6c
Cell Signaling Technology IKBKB antibody (Cell Signaling, 2078) was used in western blot on mouse samples (fig 6c). Cell (2018) ncbi
rabbit polyclonal
Cell Signaling Technology IKBKB antibody (Cell Signaling, 2678) was used . JCI Insight (2018) ncbi
rabbit monoclonal (C84E11)
  • western blot; human; loading ...; fig 1b
Cell Signaling Technology IKBKB antibody (Cell Signaling, 2078) was used in western blot on human samples (fig 1b). PLoS Pathog (2017) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 1b
In order to observe that chronic presence of internalized Escherichia coli leads to enhanced oncogenicity in colon cancer cells, Cell Signaling Technology IKBKB antibody (cell signalling, 2678) was used in western blot on human samples (fig 1b). Cell Death Dis (2017) ncbi
rabbit monoclonal (C84E11)
  • western blot; mouse; loading ...; fig 3c
Cell Signaling Technology IKBKB antibody (Cell Signaling, 2078) was used in western blot on mouse samples (fig 3c). Oncotarget (2016) ncbi
rabbit monoclonal (C84E11)
  • western blot; mouse; loading ...; fig 5a
In order to explore the mechanism by which metformin attenuates cardiovascular disease, Cell Signaling Technology IKBKB antibody (Cell Signalling, 2078) was used in western blot on mouse samples (fig 5a). Circ Res (2016) ncbi
rabbit monoclonal (C84E11)
  • western blot; mouse; loading ...; fig 4a
Cell Signaling Technology IKBKB antibody (Cell signaling, 2078) was used in western blot on mouse samples (fig 4a). elife (2016) ncbi
rabbit monoclonal (C84E11)
  • western blot; human; fig 4
Cell Signaling Technology IKBKB antibody (Cell signaling, 2078P) was used in western blot on human samples (fig 4). Nat Immunol (2016) ncbi
rabbit polyclonal
  • western blot; human; fig 4
In order to characterize prevention of apoptosis by degrading BBC3/PUMA due to chaperone-mediated autophagy, Cell Signaling Technology IKBKB antibody (Cell Signaling Tech, 2678) was used in western blot on human samples (fig 4). Autophagy (2015) ncbi
rabbit monoclonal (C84E11)
  • western blot; human; fig s1
  • western blot; mouse; fig 1
Cell Signaling Technology IKBKB antibody (Cell Signaling, 2078) was used in western blot on human samples (fig s1) and in western blot on mouse samples (fig 1). Sci Rep (2015) ncbi
rabbit monoclonal (C84E11)
  • western blot; human; fig f4
Cell Signaling Technology IKBKB antibody (cell signaling technology, 2078S) was used in western blot on human samples (fig f4). Oncotarget (2015) ncbi
rabbit monoclonal (C84E11)
  • western blot; human; fig 2
Cell Signaling Technology IKBKB antibody (Cell Signaling Technology, 2078) was used in western blot on human samples (fig 2). Nucleic Acids Res (2015) ncbi
rabbit monoclonal (C84E11)
  • western blot; mouse; fig 6
Cell Signaling Technology IKBKB antibody (Cell signaling, 2078) was used in western blot on mouse samples (fig 6). Infect Immun (2015) ncbi
rabbit polyclonal
  • western blot; rat
Cell Signaling Technology IKBKB antibody (Cell Signaling Technology, 2678S) was used in western blot on rat samples . Apoptosis (2015) ncbi
rabbit monoclonal (C84E11)
  • western blot; human
Cell Signaling Technology IKBKB antibody (Cell Signaling Technology, 2078) was used in western blot on human samples . J Invest Dermatol (2015) ncbi
rabbit monoclonal (C84E11)
  • western blot; human
In order to study the effect of a UBE2N inhibitor on neuroblastoma and its mechanism, Cell Signaling Technology IKBKB antibody (Cell Signaling Technology, 2078) was used in western blot on human samples . Cell Death Dis (2014) ncbi
rabbit polyclonal
  • immunoprecipitation; human; 1:1000; loading ...; fig s2
  • western blot; human; 1:1000; loading ...; fig s2
Cell Signaling Technology IKBKB antibody (cell signalling, 2678) was used in immunoprecipitation on human samples at 1:1000 (fig s2) and in western blot on human samples at 1:1000 (fig s2). Nat Cell Biol (2014) ncbi
rabbit polyclonal
  • western blot; human
Cell Signaling Technology IKBKB antibody (Cell Signaling, 2678) was used in western blot on human samples . Cancer Res (2014) ncbi
rabbit monoclonal (C84E11)
  • western blot; human
In order to study the mechanism by which Tax-2 activates NFkB, Cell Signaling Technology IKBKB antibody (Cell Signaling Technology, C84E11) was used in western blot on human samples . J Virol (2013) ncbi
rabbit monoclonal (C84E11)
  • western blot; human
Cell Signaling Technology IKBKB antibody (Cell Signaling, C84E11) was used in western blot on human samples . J Biol Chem (2012) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; fig 4a
Cell Signaling Technology IKBKB antibody (Cell Signaling Technology, 2678) was used in western blot on human samples at 1:1000 (fig 4a). PLoS ONE (2011) ncbi
Articles Reviewed
  1. Panda S, Gekara N. The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex. Nat Commun. 2018;9:4654 pubmed publisher
  2. Zhang X, Zhang M, Wang C. Loss of LRRC25 accelerates pathological cardiac hypertrophy through promoting fibrosis and inflammation regulated by TGF-β1. Biochem Biophys Res Commun. 2018;506:137-144 pubmed publisher
  3. Chuang H, Tsai C, Hsueh C, Tan T. GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease. Sci Adv. 2018;4:eaat5401 pubmed publisher
  4. Zhao P, Wong K, Sun X, Reilly S, Uhm M, Liao Z, et al. TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue. Cell. 2018;172:731-743.e12 pubmed publisher
  5. Sui Y, Liu Z, Park S, Thatcher S, Zhu B, Fernandez J, et al. IKK? is a ?-catenin kinase that regulates mesenchymal stem cell differentiation. JCI Insight. 2018;3: pubmed publisher
  6. Fang R, Jiang Q, Zhou X, Wang C, Guan Y, Tao J, et al. MAVS activates TBK1 and IKK? through TRAFs in NEMO dependent and independent manner. PLoS Pathog. 2017;13:e1006720 pubmed publisher
  7. Sahu U, Choudhury A, Parvez S, Biswas S, Kar S. Induction of intestinal stemness and tumorigenicity by aberrant internalization of commensal non-pathogenic E. coli. Cell Death Dis. 2017;8:e2667 pubmed publisher
  8. Zhou Y, Xu H, Ding Y, Lu Q, Zou M, Song P. AMPK?1 deletion in fibroblasts promotes tumorigenesis in athymic nude mice by p52-mediated elevation of erythropoietin and CDK2. Oncotarget. 2016;7:53654-53667 pubmed publisher
  9. Cameron A, Morrison V, Levin D, Mohan M, Forteath C, Beall C, et al. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circ Res. 2016;119:652-65 pubmed publisher
  10. Yu Z, Chen T, Li X, Yang M, Tang S, Zhu X, et al. Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response. elife. 2016;5: pubmed publisher
  11. Starokadomskyy P, Gemelli T, Rios J, Xing C, Wang R, Li H, et al. DNA polymerase-? regulates the activation of type I interferons through cytosolic RNA:DNA synthesis. Nat Immunol. 2016;17:495-504 pubmed publisher
  12. Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, et al. Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA. Autophagy. 2015;11:1623-35 pubmed publisher
  13. Chen I, Hsu P, Hsu W, Chen N, Tseng P. Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation. Sci Rep. 2015;5:12300 pubmed publisher
  14. Yang L, Zhang S, George S, Teng R, You X, Xu M, et al. Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms. Oncotarget. 2015;6:14953-69 pubmed
  15. Wu Z, Wang C, Bai M, Li X, Mei Q, Li X, et al. An LRP16-containing preassembly complex contributes to NF-κB activation induced by DNA double-strand breaks. Nucleic Acids Res. 2015;43:3167-79 pubmed publisher
  16. Kim K, Kim N, Kim S, Kim I, Kim K, Lee G. Cyclo(Phe-Pro) produced by the human pathogen Vibrio vulnificus inhibits host innate immune responses through the NF-κB pathway. Infect Immun. 2015;83:1150-61 pubmed publisher
  17. Bharti S, Rani N, Bhatia J, Arya D. 5-HT2B receptor blockade attenuates β-adrenergic receptor-stimulated myocardial remodeling in rats via inhibiting apoptosis: role of MAPKs and HSPs. Apoptosis. 2015;20:455-65 pubmed publisher
  18. Wu N, Huang D, Tsou H, Lin Y, Lin W. Syk mediates IL-17-induced CCL20 expression by targeting Act1-dependent K63-linked ubiquitination of TRAF6. J Invest Dermatol. 2015;135:490-498 pubmed publisher
  19. Cheng J, Fan Y, Xu X, Dou J, Tang Y, Zhong X, et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 2014;5:e1079 pubmed publisher
  20. Piao H, Yuan Y, Wang M, Sun Y, Liang H, Ma L. ?-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-?B signalling. Nat Cell Biol. 2014;16:245-54 pubmed publisher
  21. Hast B, Cloer E, Goldfarb D, Li H, Siesser P, Yan F, et al. Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination. Cancer Res. 2014;74:808-17 pubmed publisher
  22. Liu Y, Hawkins O, Su Y, Vilgelm A, Sobolik T, Thu Y, et al. Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-?B impairs this drug-induced senescence. EMBO Mol Med. 2013;5:149-66 pubmed publisher
  23. Journo C, Bonnet A, Favre Bonvin A, Turpin J, Vinera J, C t E, et al. Human T cell leukemia virus type 2 tax-mediated NF-?B activation involves a mechanism independent of Tax conjugation to ubiquitin and SUMO. J Virol. 2013;87:1123-36 pubmed publisher
  24. Lecat A, Di Valentin E, Somja J, Jourdan S, Fillet M, Kufer T, et al. The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as a negative regulator of NOD2 protein signaling by inhibiting its oligomerization process. J Biol Chem. 2012;287:29213-26 pubmed publisher
  25. Wu L, Shao L, An N, Wang J, Pazhanisamy S, Feng W, et al. IKK? regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells. PLoS ONE. 2011;6:e18447 pubmed publisher