This is a Validated Antibody Database (VAD) review about cow HDAC2, based on 21 published articles (read how Labome selects the articles), using HDAC2 antibody in all methods. It is aimed to help Labome visitors find the most suited HDAC2 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
HDAC2 synonym: histone deacetylase 2

Knockout validation
EMD Millipore
mouse monoclonal (3F3)
  • western blot knockout validation; mouse; 1:2000; fig 1
EMD Millipore HDAC2 antibody (Millipore, 05-814) was used in western blot knockout validation on mouse samples at 1:2000 (fig 1). Proc Natl Acad Sci U S A (2014) ncbi
EMD Millipore
mouse monoclonal (3F3)
  • western blot knockout validation; mouse; 1:10,000; fig 4
  • immunocytochemistry; mouse; 1:200; fig 1
EMD Millipore HDAC2 antibody (Millipore, 05-814) was used in western blot knockout validation on mouse samples at 1:10,000 (fig 4) and in immunocytochemistry on mouse samples at 1:200 (fig 1). Proc Natl Acad Sci U S A (2012) ncbi
Abcam
mouse monoclonal (HDAC2-62)
  • chromatin immunoprecipitation; mouse; loading ...; fig 4a
Abcam HDAC2 antibody (Abcam, ab12169) was used in chromatin immunoprecipitation on mouse samples (fig 4a). Nat Commun (2018) ncbi
mouse monoclonal (HDAC2-62)
  • chromatin immunoprecipitation; human; loading ...; fig s4b
  • western blot; human; 1:100; loading ...; fig 3a
Abcam HDAC2 antibody (Abcam, ab12169) was used in chromatin immunoprecipitation on human samples (fig s4b) and in western blot on human samples at 1:100 (fig 3a). Nat Commun (2018) ncbi
mouse monoclonal (HDAC2-62)
  • immunohistochemistry - frozen section; mouse; loading ...; fig 6b
In order to investigate the role of lysine specific demethylase 1 in neuronal maturation in the olfactory system, Abcam HDAC2 antibody (Abcam, ab12169) was used in immunohistochemistry - frozen section on mouse samples (fig 6b). J Comp Neurol (2017) ncbi
mouse monoclonal (3F3)
  • western blot; mouse; 1:2000; fig 4a
Abcam HDAC2 antibody (Abcam, ab51832) was used in western blot on mouse samples at 1:2000 (fig 4a). Front Cell Neurosci (2017) ncbi
mouse monoclonal (HDAC2-62)
  • ChIP-Seq; human; loading ...; fig s5o
  • western blot; human; loading ...; fig s5l
In order to demonstrate that iPS-derived cardiomyocytes with a heterozygous GATA4-G296S missense mutation show impaired contractility, calcium handling, and metabolic activity, Abcam HDAC2 antibody (Abcam, ab12169) was used in ChIP-Seq on human samples (fig s5o) and in western blot on human samples (fig s5l). Cell (2016) ncbi
mouse monoclonal (HDAC2-62)
  • western blot; mouse; 1:1000; loading ...; fig 6a
In order to examine the effect of piceatannol on renal fibrosis and histone deacetylase expression in a mouse model of unilateral ureteral obstruction, Abcam HDAC2 antibody (Abcam, ab12169) was used in western blot on mouse samples at 1:1000 (fig 6a). PLoS ONE (2016) ncbi
Santa Cruz Biotechnology
mouse monoclonal (3F3)
  • western blot; mouse; 1:500
Santa Cruz Biotechnology HDAC2 antibody (Santa Cruz, sc-81599) was used in western blot on mouse samples at 1:500. Toxicol Appl Pharmacol (2015) ncbi
mouse monoclonal (3F3)
  • western blot; human; 1:1000; fig 2
Santa Cruz Biotechnology HDAC2 antibody (Santa Cruz, sc-81599) was used in western blot on human samples at 1:1000 (fig 2). Acta Neuropathol Commun (2015) ncbi
EMD Millipore
mouse monoclonal (3F3)
  • immunocytochemistry; mouse; loading ...; fig s6a
EMD Millipore HDAC2 antibody (Millipore, 05-814) was used in immunocytochemistry on mouse samples (fig s6a). Development (2015) ncbi
mouse monoclonal
  • chromatin immunoprecipitation; human; 5 ul/mg; fig 8
In order to investigate if microRNAs contribute to macrophage's fibrogenesis, EMD Millipore HDAC2 antibody (Millipore, 17?C10237) was used in chromatin immunoprecipitation on human samples at 5 ul/mg (fig 8). Nat Commun (2015) ncbi
mouse monoclonal
  • chromatin immunoprecipitation; human; fig 5
In order to study the relationship between hyperactivation of MAPK and the estrogen receptor in breast cancer cells, EMD Millipore HDAC2 antibody (Millipore, 17-10237) was used in chromatin immunoprecipitation on human samples (fig 5). Breast Cancer Res Treat (2014) ncbi
mouse monoclonal (3F3)
  • chromatin immunoprecipitation; human
EMD Millipore HDAC2 antibody (Millipore, 05-814) was used in chromatin immunoprecipitation on human samples . Cell Death Differ (2014) ncbi
mouse monoclonal (3F3)
  • western blot knockout validation; mouse; 1:2000; fig 1
EMD Millipore HDAC2 antibody (Millipore, 05-814) was used in western blot knockout validation on mouse samples at 1:2000 (fig 1). Proc Natl Acad Sci U S A (2014) ncbi
mouse monoclonal (3F3)
  • western blot; mouse; fig 1
EMD Millipore HDAC2 antibody (Millipore, 3F3) was used in western blot on mouse samples (fig 1). Oncogene (2014) ncbi
mouse monoclonal
  • western blot; mouse; 1:2000
EMD Millipore HDAC2 antibody (Millipore, 17-10237) was used in western blot on mouse samples at 1:2000. Cell Death Dis (2013) ncbi
mouse monoclonal (3F3)
  • chromatin immunoprecipitation; human
EMD Millipore HDAC2 antibody (Upstate, 05-814) was used in chromatin immunoprecipitation on human samples . J Biol Chem (2013) ncbi
mouse monoclonal (3F3)
  • western blot knockout validation; mouse; 1:10,000; fig 4
  • immunocytochemistry; mouse; 1:200; fig 1
EMD Millipore HDAC2 antibody (Millipore, 05-814) was used in western blot knockout validation on mouse samples at 1:10,000 (fig 4) and in immunocytochemistry on mouse samples at 1:200 (fig 1). Proc Natl Acad Sci U S A (2012) ncbi
mouse monoclonal (3F3)
  • chromatin immunoprecipitation; human
  • western blot; human
EMD Millipore HDAC2 antibody (Upstate Biotechnology, 05-814) was used in chromatin immunoprecipitation on human samples and in western blot on human samples . J Alzheimers Dis (2010) ncbi
mouse monoclonal (3F3)
  • western blot; mouse
EMD Millipore HDAC2 antibody (Millipore, 05-814) was used in western blot on mouse samples . Mol Cell Biol (2010) ncbi
Sigma-Aldrich
mouse monoclonal (HDAC2-62)
  • chromatin immunoprecipitation; mouse; fig 6b
  • western blot; mouse; 1:1000; loading ...; fig 1a
Sigma-Aldrich HDAC2 antibody (Sigma, H2663) was used in chromatin immunoprecipitation on mouse samples (fig 6b) and in western blot on mouse samples at 1:1000 (fig 1a). Nat Commun (2017) ncbi
mouse monoclonal (HDAC2-62)
  • immunohistochemistry - paraffin section; mouse; fig 1c
In order to determine the functional role of HDAC1 and HDAC2 in an acute model of optic nerve injury, Sigma-Aldrich HDAC2 antibody (Sigma, H2663) was used in immunohistochemistry - paraffin section on mouse samples (fig 1c). ASN Neuro (2015) ncbi
Articles Reviewed
  1. Singh A, Khare P, Obaid A, Conlon K, Basrur V, Depinho R, et al. SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2. Nat Commun. 2018;9:4515 pubmed publisher
  2. Lino Cardenas C, Kessinger C, Cheng Y, MacDonald C, Macgillivray T, Ghoshhajra B, et al. An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm. Nat Commun. 2018;9:1009 pubmed publisher
  3. Coleman J, Lin B, Schwob J. Dissecting LSD1-Dependent Neuronal Maturation in the Olfactory Epithelium. J Comp Neurol. 2017;525:3391-3413 pubmed publisher
  4. Jin X, Yu Z, Chen F, Lu G, Ding X, Xie L, et al. Neuronal Nitric Oxide Synthase in Neural Stem Cells Induces Neuronal Fate Commitment via the Inhibition of Histone Deacetylase 2. Front Cell Neurosci. 2017;11:66 pubmed publisher
  5. Brügger V, Duman M, Bochud M, Münger E, Heller M, Ruff S, et al. Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration. Nat Commun. 2017;8:14272 pubmed publisher
  6. Ang Y, Rivas R, Ribeiro A, Srivas R, Rivera J, Stone N, et al. Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis. Cell. 2016;167:1734-1749.e22 pubmed publisher
  7. Choi S, Piao Z, Jin L, Kim J, Kim G, Ryu Y, et al. Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling. PLoS ONE. 2016;11:e0167340 pubmed publisher
  8. Fukuda A, Mitani A, Miyashita T, Umezawa A, Akutsu H. Chromatin condensation of Xist genomic loci during oogenesis in mice. Development. 2015;142:4049-55 pubmed publisher
  9. Su S, Zhao Q, He C, Huang D, Liu J, Chen F, et al. miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program. Nat Commun. 2015;6:8523 pubmed publisher
  10. Tyler C, Hafez A, Solomon E, Allan A. Developmental exposure to 50 parts-per-billion arsenic influences histone modifications and associated epigenetic machinery in a region- and sex-specific manner in the adult mouse brain. Toxicol Appl Pharmacol. 2015;288:40-51 pubmed publisher
  11. Lebrun Julien F, Suter U. Combined HDAC1 and HDAC2 Depletion Promotes Retinal Ganglion Cell Survival After Injury Through Reduction of p53 Target Gene Expression. ASN Neuro. 2015;7: pubmed publisher
  12. Ecker J, Oehme I, Mazitschek R, Korshunov A, Kool M, Hielscher T, et al. Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma. Acta Neuropathol Commun. 2015;3:22 pubmed publisher
  13. Plotkin A, Volmar C, Wahlestedt C, AYAD N, El Ashry D. Transcriptional repression of ER through hMAPK dependent histone deacetylation by class I HDACs. Breast Cancer Res Treat. 2014;147:249-63 pubmed publisher
  14. Lezina L, Aksenova V, Ivanova T, Purmessur N, Antonov A, Tentler D, et al. KMTase Set7/9 is a critical regulator of E2F1 activity upon genotoxic stress. Cell Death Differ. 2014;21:1889-99 pubmed publisher
  15. Jamaladdin S, Kelly R, O Regan L, Dovey O, Hodson G, Millard C, et al. Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells. Proc Natl Acad Sci U S A. 2014;111:9840-5 pubmed publisher
  16. Xu Y, Swartz K, Siu K, Bhattacharyya M, Minella A. Fbw7-dependent cyclin E regulation ensures terminal maturation of bone marrow erythroid cells by restraining oxidative metabolism. Oncogene. 2014;33:3161-71 pubmed publisher
  17. Huang S, Scruggs A, Donaghy J, Horowitz J, Zaslona Z, Przybranowski S, et al. Histone modifications are responsible for decreased Fas expression and apoptosis resistance in fibrotic lung fibroblasts. Cell Death Dis. 2013;4:e621 pubmed publisher
  18. Corvetta D, Chayka O, Gherardi S, D Acunto C, Cantilena S, Valli E, et al. Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. J Biol Chem. 2013;288:8332-41 pubmed publisher
  19. Ma P, Pan H, Montgomery R, Olson E, Schultz R. Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development. Proc Natl Acad Sci U S A. 2012;109:E481-9 pubmed publisher
  20. Milagre I, Nunes M, Moutinho M, Rivera I, Fuso A, Scarpa S, et al. Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination. J Alzheimers Dis. 2010;22:1209-21 pubmed publisher
  21. Foster C, Dovey O, Lezina L, Luo J, Gant T, Barlev N, et al. Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability. Mol Cell Biol. 2010;30:4851-63 pubmed publisher