This is a Validated Antibody Database (VAD) review about cow CHUK, based on 89 published articles (read how Labome selects the articles), using CHUK antibody in all methods. It is aimed to help Labome visitors find the most suited CHUK antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
CHUK synonym: inhibitor of nuclear factor kappa-B kinase subunit alpha; I-kappa-B kinase 1; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IKK1; NFKBIKA; i kappa-B kinase alpha; ikBKA; nuclear factor NF-kappa-B inhibitor kinase alpha

Knockout validation
Cell Signaling Technology
rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig 7e
Cell Signaling Technology CHUK antibody (Cell Signaling, 2682) was used in western blot knockout validation on human samples (fig 7e). PLoS Pathog (2017) ncbi
Invitrogen
rabbit monoclonal (J.10.3)
  • western blot; human
In order to report that induction of senescence and immune surveillance limit melanoma growth, Invitrogen CHUK antibody (Pierce Biotechnology, MA5-14857) was used in western blot on human samples . EMBO Mol Med (2013) ncbi
Cell Signaling Technology
rabbit monoclonal (C84E11)
  • western blot; mouse; 1:1000; loading ...; fig 4c
Cell Signaling Technology CHUK antibody (Cell signaling technology, 2078) was used in western blot on mouse samples at 1:1000 (fig 4c). Nat Commun (2018) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 5a
Cell Signaling Technology CHUK antibody (Cell Signaling, 2682) was used in western blot on human samples (fig 5a). Biomed Pharmacother (2019) ncbi
rabbit monoclonal (16A6)
  • western blot; human; 1:800; loading ...; fig 1e
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples at 1:800 (fig 1e). Nat Commun (2018) ncbi
rabbit monoclonal (C84E11)
  • western blot; mouse; 1:1000; loading ...; fig 3g
Cell Signaling Technology CHUK antibody (Cell Signaling, 2078) was used in western blot on mouse samples at 1:1000 (fig 3g). Biochem Biophys Res Commun (2018) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 3g
Cell Signaling Technology CHUK antibody (Cell Signaling, 2682) was used in western blot on mouse samples at 1:1000 (fig 3g). Biochem Biophys Res Commun (2018) ncbi
rabbit monoclonal (16A6)
  • flow cytometry; human; 1:100; loading ...
  • western blot; human; 1:500; loading ...; fig 4f
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in flow cytometry on human samples at 1:100 and in western blot on human samples at 1:500 (fig 4f). Nature (2018) ncbi
rabbit monoclonal (16A6)
  • western blot; mouse; loading ...; fig 5a
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on mouse samples (fig 5a). Cell (2018) ncbi
rabbit monoclonal (16A6)
  • western blot; human; fig 7c
Cell Signaling Technology CHUK antibody (CST, 2697) was used in western blot on human samples (fig 7c). Cell Death Differ (2018) ncbi
rabbit polyclonal
  • immunoprecipitation; human; loading ...; fig 3e
Cell Signaling Technology CHUK antibody (Cell Signaling Technology., 2682) was used in immunoprecipitation on human samples (fig 3e). Sci Adv (2018) ncbi
rabbit monoclonal (16A6)
  • western blot; human; 1:1000; loading ...; fig s9a
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples at 1:1000 (fig s9a). Science (2018) ncbi
rabbit polyclonal
  • western blot; mouse; fig 4d
Cell Signaling Technology CHUK antibody (Cell Signaling Technology, 2682) was used in western blot on mouse samples (fig 4d). J Clin Invest (2018) ncbi
rabbit monoclonal (16A6)
  • western blot; mouse; fig 4d
Cell Signaling Technology CHUK antibody (Cell Signaling Technology, 2697s) was used in western blot on mouse samples (fig 4d). J Clin Invest (2018) ncbi
rabbit monoclonal (C84E11)
  • western blot; mouse; fig 6c
Cell Signaling Technology CHUK antibody (Cell Signaling, 2078) was used in western blot on mouse samples (fig 6c). Cell (2018) ncbi
rabbit monoclonal (16A6)
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used . JCI Insight (2018) ncbi
rabbit polyclonal
  • western blot knockout validation; human; loading ...; fig 7e
Cell Signaling Technology CHUK antibody (Cell Signaling, 2682) was used in western blot knockout validation on human samples (fig 7e). PLoS Pathog (2017) ncbi
rabbit monoclonal (C84E11)
  • western blot; human; loading ...; fig 1b
Cell Signaling Technology CHUK antibody (Cell Signaling, 2078) was used in western blot on human samples (fig 1b). PLoS Pathog (2017) ncbi
rabbit monoclonal (16A6)
  • western blot; human; 1:1000; loading ...; fig 2a
In order to research the role of TRAF3IP2 in endothelin-1 production and inflammation in endothelial cells, Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples at 1:1000 (fig 2a). Am J Physiol Heart Circ Physiol (2018) ncbi
rabbit monoclonal (16A6)
  • western blot; human; fig 2b
Cell Signaling Technology CHUK antibody (Cell Signaling Technology, 2697) was used in western blot on human samples (fig 2b). J Biol Chem (2017) ncbi
rabbit monoclonal (16A6)
  • western blot; human; loading ...; fig 3a
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples (fig 3a). J Virol (2017) ncbi
rabbit monoclonal (16A6)
  • western blot; human; loading ...; fig 5b
In order to study the activation of TAK1 by interleukin-1 and TRAF6, Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples (fig 5b). Biochem J (2017) ncbi
rabbit monoclonal (16A6)
  • western blot; human; loading ...; fig s1a
  • western blot; mouse
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples (fig s1a) and in western blot on mouse samples . Proc Natl Acad Sci U S A (2017) ncbi
rabbit monoclonal (16A6)
  • western blot; human; loading ...; fig 2b
Cell Signaling Technology CHUK antibody (Cell Signaling Technology, 2697) was used in western blot on human samples (fig 2b). Oncotarget (2017) ncbi
rabbit monoclonal (16A6)
  • western blot; human; loading ...; fig 8a
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697S) was used in western blot on human samples (fig 8a). J Immunol (2017) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 1b
In order to observe that chronic presence of internalized Escherichia coli leads to enhanced oncogenicity in colon cancer cells, Cell Signaling Technology CHUK antibody (cell signalling, 2682) was used in western blot on human samples (fig 1b). Cell Death Dis (2017) ncbi
rabbit monoclonal (16A6)
  • western blot; mouse; loading ...; fig EV3d
  • western blot; human; loading ...; fig 8a
Cell Signaling Technology CHUK antibody (cell signalling, 2697) was used in western blot on mouse samples (fig EV3d) and in western blot on human samples (fig 8a). EMBO J (2017) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 5a
In order to research the effect of VHL on immune response against renal cell carcinoma and its mechanism, Cell Signaling Technology CHUK antibody (Cell Signaling, 2682) was used in western blot on human samples (fig 5a). J Cell Biol (2017) ncbi
rabbit monoclonal (16A6)
  • western blot; human; loading ...; fig 1b, 2b
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples (fig 1b, 2b). J Biol Chem (2017) ncbi
rabbit monoclonal (16A6)
  • western blot; mouse; loading ...; fig 5b
In order to test the effect of paeoniflorin in experimental autoimmune encephalomyelitis, an animal model for multiple sclerosis, Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on mouse samples (fig 5b). Sci Rep (2017) ncbi
rabbit monoclonal (16A6)
  • western blot; mouse; loading ...; fig 2a
  • western blot; human; loading ...; fig 1a
In order to discover that Tax recruits linear (Met1-linked) ubiquitin chain assembly complex to the IkB kinase complex, Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on mouse samples (fig 2a) and in western blot on human samples (fig 1a). PLoS Pathog (2017) ncbi
rabbit monoclonal (16A6)
  • western blot; human; loading ...; fig 1a
Cell Signaling Technology CHUK antibody (cell signalling, 2697) was used in western blot on human samples (fig 1a). J Immunol (2017) ncbi
rabbit monoclonal (16A6)
  • western blot; mouse; loading ...; fig 2e
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on mouse samples (fig 2e). Sci Rep (2016) ncbi
rabbit monoclonal (16A6)
  • western blot; human; 1:1000; fig 6d
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples at 1:1000 (fig 6d). Front Pharmacol (2016) ncbi
rabbit polyclonal
  • western blot; human; fig 5
Cell Signaling Technology CHUK antibody (cell Signaling Tech, CST2682) was used in western blot on human samples (fig 5). Curr Biol (2016) ncbi
rabbit monoclonal (16A6)
  • western blot; mouse; fig 4G
In order to show that deletion of the gene encoding RAB guanine nucleotide exchange factor 1 in keratinocytes severely impairs epidermal barrier function in mice, Cell Signaling Technology CHUK antibody (Cell signaling, 16A6) was used in western blot on mouse samples (fig 4G). J Clin Invest (2016) ncbi
rabbit monoclonal (16A6)
  • flow cytometry; human; loading ...; fig 1a
Cell Signaling Technology CHUK antibody (Cell signaling, 16A6) was used in flow cytometry on human samples (fig 1a). J Immunol (2016) ncbi
rabbit monoclonal (16A6)
  • western blot; pig; loading ...; fig 1a
In order to demonstrate that injury results in TAK1 activation by phosphorylation and K63-linked polyubiquitination, Cell Signaling Technology CHUK antibody (Cell Signaling, 16A6) was used in western blot on pig samples (fig 1a). Arthritis Rheumatol (2017) ncbi
rabbit monoclonal (16A6)
  • western blot; mouse; 1:1000; loading ...; fig 9a
Cell Signaling Technology CHUK antibody (Cell Signaling Technology, 16A6) was used in western blot on mouse samples at 1:1000 (fig 9a). Drug Des Devel Ther (2016) ncbi
rabbit monoclonal (16A6)
  • western blot; mouse; 1:1000; loading ...; fig 2a
In order to explore how epicatechin inhibits visceral adipose tissue inflammation induced by a high fat diet, Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on mouse samples at 1:1000 (fig 2a). Int J Biochem Cell Biol (2016) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 2a
In order to explore how epicatechin inhibits visceral adipose tissue inflammation induced by a high fat diet, Cell Signaling Technology CHUK antibody (Cell Signaling, 2682) was used in western blot on mouse samples at 1:1000 (fig 2a). Int J Biochem Cell Biol (2016) ncbi
rabbit monoclonal (16A6)
  • western blot; human; fig 1
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples (fig 1). Proc Natl Acad Sci U S A (2016) ncbi
rabbit monoclonal (16A6)
  • western blot; human; 1:1000; fig s15
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples at 1:1000 (fig s15). Nat Commun (2016) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 2a
Cell Signaling Technology CHUK antibody (Cell Signaling, CST-2682) was used in western blot on human samples (fig 2a). Oncotarget (2016) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 3c
Cell Signaling Technology CHUK antibody (Cell Signaling, 2682) was used in western blot on mouse samples (fig 3c). Oncotarget (2016) ncbi
rabbit monoclonal (C84E11)
  • western blot; mouse; loading ...; fig 3c
Cell Signaling Technology CHUK antibody (Cell Signaling, 2078) was used in western blot on mouse samples (fig 3c). Oncotarget (2016) ncbi
rabbit monoclonal (16A6)
  • western blot; mouse; loading ...; fig 5a
In order to explore the mechanism by which metformin attenuates cardiovascular disease, Cell Signaling Technology CHUK antibody (Cell Signalling, 2697) was used in western blot on mouse samples (fig 5a). Circ Res (2016) ncbi
rabbit monoclonal (C84E11)
  • western blot; mouse; loading ...; fig 5a
In order to explore the mechanism by which metformin attenuates cardiovascular disease, Cell Signaling Technology CHUK antibody (Cell Signalling, 2078) was used in western blot on mouse samples (fig 5a). Circ Res (2016) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 3b
Cell Signaling Technology CHUK antibody (cell signalling, 2682) was used in western blot on human samples (fig 3b). Nucleic Acids Res (2016) ncbi
rabbit monoclonal (16A6)
  • western blot; human; loading ...; fig 3b
Cell Signaling Technology CHUK antibody (cell signalling, 2697) was used in western blot on human samples (fig 3b). Nucleic Acids Res (2016) ncbi
rabbit monoclonal (16A6)
  • western blot; mouse; fig 5
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on mouse samples (fig 5). PLoS Pathog (2016) ncbi
rabbit monoclonal (16A6)
  • western blot; human; loading ...; fig 1a
In order to investigate NF-KB signaling in natural killer cells, Cell Signaling Technology CHUK antibody (Cell Signaling, 16A6) was used in western blot on human samples (fig 1a). Nat Commun (2016) ncbi
rabbit monoclonal (16A6)
  • western blot; human; loading ...; fig 3d
In order to investigate the epigenetic regulation of Beclin-1, Cell Signaling Technology CHUK antibody (Cell signaling, 2697) was used in western blot on human samples (fig 3d). Oncotarget (2016) ncbi
rabbit monoclonal (16A6)
  • western blot; human; fig 4
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples (fig 4). Biochem Biophys Res Commun (2016) ncbi
rabbit monoclonal (16A6)
  • western blot; human; 1:1000; loading ...; fig 2a
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples at 1:1000 (fig 2a). Dig Dis Sci (2016) ncbi
rabbit monoclonal (C84E11)
  • western blot; mouse; loading ...; fig 4a
Cell Signaling Technology CHUK antibody (Cell signaling, 2078) was used in western blot on mouse samples (fig 4a). elife (2016) ncbi
rabbit monoclonal (C84E11)
  • western blot; human; fig 4
Cell Signaling Technology CHUK antibody (Cell signaling, 2078P) was used in western blot on human samples (fig 4). Nat Immunol (2016) ncbi
rabbit monoclonal (16A6)
  • immunocytochemistry; mouse; loading ...; fig 5c
  • western blot; mouse; loading ...; fig 5d
In order to study papaverine, lipopolysaccharide-induced microglial activation, and NF-kB signaling pathway, Cell Signaling Technology CHUK antibody (cell signalling, 2697) was used in immunocytochemistry on mouse samples (fig 5c) and in western blot on mouse samples (fig 5d). Drug Des Devel Ther (2016) ncbi
rabbit monoclonal (16A6)
  • western blot; mouse; 1:1000; fig 5
In order to study how alphav integrins regulate Toll-like receptor signaling and intracellular trafficking, Cell Signaling Technology CHUK antibody (Cell Signaling Technology, 16A6) was used in western blot on mouse samples at 1:1000 (fig 5). Nat Commun (2016) ncbi
rabbit monoclonal (16A6)
  • western blot; mouse; fig 3
Cell Signaling Technology CHUK antibody (Cell Signaling Technolog, 2697) was used in western blot on mouse samples (fig 3). Cell Death Differ (2016) ncbi
rabbit monoclonal (16A6)
  • western blot; human; loading ...; fig 2b, 2c
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples (fig 2b, 2c). Nat Genet (2016) ncbi
rabbit monoclonal (16A6)
  • western blot; human; loading ...; fig 5d
Cell Signaling Technology CHUK antibody (Cell signaling, 2697) was used in western blot on human samples (fig 5d). J Exp Med (2015) ncbi
rabbit polyclonal
  • western blot; human
Cell Signaling Technology CHUK antibody (Cell Signaling, 2682) was used in western blot on human samples . Sci Rep (2015) ncbi
rabbit polyclonal
  • western blot; human; fig s4
In order to characterize prevention of apoptosis by degrading BBC3/PUMA due to chaperone-mediated autophagy, Cell Signaling Technology CHUK antibody (Cell Signaling Tech, 2682) was used in western blot on human samples (fig s4). Autophagy (2015) ncbi
rabbit monoclonal (C84E11)
  • western blot; human; fig s1
  • western blot; mouse; fig 1
Cell Signaling Technology CHUK antibody (Cell Signaling, 2078) was used in western blot on human samples (fig s1) and in western blot on mouse samples (fig 1). Sci Rep (2015) ncbi
rabbit monoclonal (16A6)
  • western blot; human; fig 1, 5, 6
  • western blot; mouse; fig 1, 5, 6
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples (fig 1, 5, 6) and in western blot on mouse samples (fig 1, 5, 6). J Biol Chem (2015) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 4f
Cell Signaling Technology CHUK antibody (Cell Signaling, 2682) was used in western blot on mouse samples (fig 4f). Cell Death Differ (2015) ncbi
rabbit monoclonal (16A6)
  • western blot; human; fig 3
Cell Signaling Technology CHUK antibody (Cell Signaling, 16A6) was used in western blot on human samples (fig 3). J Exp Med (2015) ncbi
rabbit monoclonal (16A6)
  • western blot; human; fig 8.a,b,c,d
In order to study the effects of cocaine on HIV-infected myeloid cells, Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples (fig 8.a,b,c,d). Virology (2015) ncbi
rabbit monoclonal (C84E11)
  • western blot; human; fig f4
Cell Signaling Technology CHUK antibody (cell signaling technology, 2078S) was used in western blot on human samples (fig f4). Oncotarget (2015) ncbi
rabbit polyclonal
  • western blot; human; fig f4
Cell Signaling Technology CHUK antibody (cell signaling technology, 2682S) was used in western blot on human samples (fig f4). Oncotarget (2015) ncbi
rabbit monoclonal (16A6)
  • western blot; human; fig 1d
Cell Signaling Technology CHUK antibody (Cell Signaling Technology, 2697) was used in western blot on human samples (fig 1d). J Biol Chem (2015) ncbi
rabbit monoclonal (16A6)
  • western blot; human; 1:1000; loading ...; fig 6e
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples at 1:1000 (fig 6e). Nat Commun (2015) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 5e
Cell Signaling Technology CHUK antibody (Cell Signaling, 2682) was used in western blot on mouse samples at 1:1000 (fig 5e). Nat Commun (2015) ncbi
rabbit monoclonal (16A6)
  • western blot; human; 1:1000
In order to study the efficacy of (-)-Epicatechin in the prevention of tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity, Cell Signaling Technology CHUK antibody (Cell Signaling Technology, 2697) was used in western blot on human samples at 1:1000. Arch Biochem Biophys (2015) ncbi
rabbit monoclonal (C84E11)
  • western blot; human; fig 2
Cell Signaling Technology CHUK antibody (Cell Signaling Technology, 2078) was used in western blot on human samples (fig 2). Nucleic Acids Res (2015) ncbi
rabbit monoclonal (C84E11)
  • western blot; mouse; fig 6
Cell Signaling Technology CHUK antibody (Cell signaling, 2078) was used in western blot on mouse samples (fig 6). Infect Immun (2015) ncbi
rabbit polyclonal
  • flow cytometry; human; loading ...; fig 4a
Cell Signaling Technology CHUK antibody (Cell Signaling, 2682P) was used in flow cytometry on human samples (fig 4a). Invest New Drugs (2015) ncbi
rabbit monoclonal (16A6)
  • western blot; human; 1:1000
Cell Signaling Technology CHUK antibody (Cell signaling, 2697) was used in western blot on human samples at 1:1000. PLoS ONE (2014) ncbi
rabbit monoclonal (16A6)
  • western blot; human
Cell Signaling Technology CHUK antibody (CST, 2697S) was used in western blot on human samples . Oncotarget (2014) ncbi
rabbit monoclonal (C84E11)
  • western blot; human
Cell Signaling Technology CHUK antibody (Cell Signaling Technology, 2078) was used in western blot on human samples . J Invest Dermatol (2015) ncbi
rabbit monoclonal (16A6)
  • western blot; mouse
Cell Signaling Technology CHUK antibody (Cell Signaling Technology, 2697) was used in western blot on mouse samples . J Biol Chem (2014) ncbi
rabbit monoclonal (16A6)
  • western blot; mouse; 1:250
Cell Signaling Technology CHUK antibody (Cell Signaling Technology, 2697) was used in western blot on mouse samples at 1:250. Biol Reprod (2014) ncbi
rabbit monoclonal (16A6)
  • western blot; mouse; fig 6
Cell Signaling Technology CHUK antibody (Cell signaling, 2697) was used in western blot on mouse samples (fig 6). Nat Commun (2014) ncbi
rabbit monoclonal (16A6)
  • immunohistochemistry - paraffin section; mouse; 1:150; fig 5
In order to determine how loss of Trp53 and Cdh1 in the uterus can induce chronic inflammation with a change in the tumor microenvironment, Cell Signaling Technology CHUK antibody (Cell Signaling Technology, 2697) was used in immunohistochemistry - paraffin section on mouse samples at 1:150 (fig 5). Oncogene (2015) ncbi
rabbit monoclonal (16A6)
Cell Signaling Technology CHUK antibody (Cell Signaling Technology, 2697L) was used . Neurobiol Dis (2014) ncbi
rabbit monoclonal (16A6)
  • western blot; rat
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on rat samples . World J Gastroenterol (2014) ncbi
rabbit monoclonal (C84E11)
  • western blot; human
In order to study the effect of a UBE2N inhibitor on neuroblastoma and its mechanism, Cell Signaling Technology CHUK antibody (Cell Signaling Technology, 2078) was used in western blot on human samples . Cell Death Dis (2014) ncbi
rabbit monoclonal (16A6)
  • western blot; human
In order to compare the effect of exercise training and resveratrol treatment on metabolic and inflammatory status in skeletal muscle of aged men, Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples . J Physiol (2014) ncbi
rabbit monoclonal (16A6)
  • western blot; human; 1:1000; loading ...; fig s2
Cell Signaling Technology CHUK antibody (cell signalling, 2697) was used in western blot on human samples at 1:1000 (fig s2). Nat Cell Biol (2014) ncbi
rabbit monoclonal (16A6)
  • western blot; rat; 1:1000
Cell Signaling Technology CHUK antibody (Cell Signaling Technology, 2697) was used in western blot on rat samples at 1:1000. J Nutr Biochem (2014) ncbi
rabbit monoclonal (16A6)
  • western blot; mouse; 1:1000
In order to investigate the role of microglial derived tumor necrosis factor alpha in neuronal cell cycle progression, Cell Signaling Technology CHUK antibody (Cell Signaling, 2697S) was used in western blot on mouse samples at 1:1000. Neurobiol Dis (2014) ncbi
rabbit polyclonal
  • western blot; mouse
Cell Signaling Technology CHUK antibody (Cell signaling technology, 2682) was used in western blot on mouse samples . J Hepatol (2014) ncbi
rabbit monoclonal (16A6)
  • immunohistochemistry - paraffin section; mouse
Cell Signaling Technology CHUK antibody (Cell signaling, 2697) was used in immunohistochemistry - paraffin section on mouse samples . Exp Toxicol Pathol (2013) ncbi
rabbit monoclonal (C84E11)
  • western blot; human
In order to study the mechanism by which Tax-2 activates NFkB, Cell Signaling Technology CHUK antibody (Cell Signaling Technology, C84E11) was used in western blot on human samples . J Virol (2013) ncbi
rabbit monoclonal (16A6)
  • western blot; human
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697) was used in western blot on human samples . Cell Cycle (2012) ncbi
rabbit monoclonal (C84E11)
  • western blot; human
Cell Signaling Technology CHUK antibody (Cell Signaling, C84E11) was used in western blot on human samples . J Biol Chem (2012) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; fig 4a
Cell Signaling Technology CHUK antibody (Cell Signaling Technology, 2682) was used in western blot on human samples at 1:1000 (fig 4a). PLoS ONE (2011) ncbi
rabbit monoclonal (16A6)
  • western blot; human; fig 5
Cell Signaling Technology CHUK antibody (Cell Signaling, 2697S) was used in western blot on human samples (fig 5). Nat Immunol (2011) ncbi
Articles Reviewed
  1. Panda S, Gekara N. The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex. Nat Commun. 2018;9:4654 pubmed publisher
  2. Lou C, Lu H, Ma Z, Liu C, Zhang Y. Ginkgolide B enhances gemcitabine sensitivity in pancreatic cancer cell lines via inhibiting PAFR/NF-кB pathway. Biomed Pharmacother. 2019;109:563-572 pubmed publisher
  3. Sheng C, Yao C, Wang Z, Chen H, Zhao Y, Xu D, et al. Cyclophilin J limits inflammation through the blockage of ubiquitin chain sensing. Nat Commun. 2018;9:4381 pubmed publisher
  4. Zhang X, Zhang M, Wang C. Loss of LRRC25 accelerates pathological cardiac hypertrophy through promoting fibrosis and inflammation regulated by TGF-β1. Biochem Biophys Res Commun. 2018;506:137-144 pubmed publisher
  5. Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, et al. LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration. Nature. 2018;562:605-609 pubmed publisher
  6. Xu X, Xu J, Wu J, Hu Y, Han Y, Gu Y, et al. Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to Activate Macrophage Innate Response. Cell. 2018;175:1336-1351.e17 pubmed publisher
  7. Fauster A, Rebsamen M, Willmann K, César Razquin A, Girardi E, Bigenzahn J, et al. Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Cell Death Differ. 2018;: pubmed publisher
  8. Chuang H, Tsai C, Hsueh C, Tan T. GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease. Sci Adv. 2018;4:eaat5401 pubmed publisher
  9. Cuchet Lourenço D, Eletto D, Wu C, Plagnol V, Papapietro O, CURTIS J, et al. Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation. Science. 2018;361:810-813 pubmed publisher
  10. Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, et al. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128:4148-4162 pubmed publisher
  11. Zhao P, Wong K, Sun X, Reilly S, Uhm M, Liao Z, et al. TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue. Cell. 2018;172:731-743.e12 pubmed publisher
  12. Sui Y, Liu Z, Park S, Thatcher S, Zhu B, Fernandez J, et al. IKK? is a ?-catenin kinase that regulates mesenchymal stem cell differentiation. JCI Insight. 2018;3: pubmed publisher
  13. Fang R, Jiang Q, Zhou X, Wang C, Guan Y, Tao J, et al. MAVS activates TBK1 and IKK? through TRAFs in NEMO dependent and independent manner. PLoS Pathog. 2017;13:e1006720 pubmed publisher
  14. Padilla J, Carpenter A, Das N, Kandikattu H, López Ongil S, Martinez Lemus L, et al. TRAF3IP2 mediates high glucose-induced endothelin-1 production as well as endothelin-1-induced inflammation in endothelial cells. Am J Physiol Heart Circ Physiol. 2018;314:H52-H64 pubmed publisher
  15. Wu G, Mu T, Gao Z, Wang J, Sy M, Li C. Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production. J Biol Chem. 2017;292:18747-18759 pubmed publisher
  16. Franz S, Rennert P, Woznik M, Grützke J, Lüdde A, Arriero Pais E, et al. Mumps Virus SH Protein Inhibits NF-κB Activation by Interacting with Tumor Necrosis Factor Receptor 1, Interleukin-1 Receptor 1, and Toll-Like Receptor 3 Complexes. J Virol. 2017;91: pubmed publisher
  17. Zhang J, MacArtney T, Peggie M, Cohen P. Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3. Biochem J. 2017;474:2235-2248 pubmed publisher
  18. Strickson S, Emmerich C, Goh E, Zhang J, Kelsall I, MacArtney T, et al. Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling. Proc Natl Acad Sci U S A. 2017;114:E3481-E3489 pubmed publisher
  19. Wang X, Wang R, Luo M, Li C, Wang H, Huan C, et al. (DEAD)-box RNA helicase 3 modulates NF-κB signal pathway by controlling the phosphorylation of PP2A-C subunit. Oncotarget. 2017;8:33197-33213 pubmed publisher
  20. Xia Z, Xu G, Yang X, Peng N, Zuo Q, Zhu S, et al. Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex. J Immunol. 2017;198:3690-3704 pubmed publisher
  21. Sahu U, Choudhury A, Parvez S, Biswas S, Kar S. Induction of intestinal stemness and tumorigenicity by aberrant internalization of commensal non-pathogenic E. coli. Cell Death Dis. 2017;8:e2667 pubmed publisher
  22. Lafont E, Kantari Mimoun C, Dráber P, De Miguel D, Hartwig T, Reichert M, et al. The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. EMBO J. 2017;36:1147-1166 pubmed publisher
  23. Labrousse Arias D, Martínez Alonso E, Corral Escariz M, Bienes Martínez R, Berridy J, Serrano Oviedo L, et al. VHL promotes immune response against renal cell carcinoma via NF-κB-dependent regulation of VCAM-1. J Cell Biol. 2017;216:835-847 pubmed publisher
  24. Hsia H, Hutti J, Baldwin A. Cytosolic DNA Promotes Signal Transducer and Activator of Transcription 3 (STAT3) Phosphorylation by TANK-binding Kinase 1 (TBK1) to Restrain STAT3 Activity. J Biol Chem. 2017;292:5405-5417 pubmed publisher
  25. Zhang H, Qi Y, Yuan Y, Cai L, Xu H, Zhang L, et al. Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation. Sci Rep. 2017;7:41887 pubmed publisher
  26. Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, et al. HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains. PLoS Pathog. 2017;13:e1006162 pubmed publisher
  27. Dudhgaonkar S, Ranade S, Nagar J, Subramani S, Prasad D, Karunanithi P, et al. Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity. J Immunol. 2017;198:1308-1319 pubmed publisher
  28. Huh H, Ra E, Lee T, Kang S, Park A, Lee E, et al. STRAP Acts as a Scaffolding Protein in Controlling the TLR2/4 Signaling Pathway. Sci Rep. 2016;6:38849 pubmed publisher
  29. Lin C, Lin W, Cho R, Wang C, Hsiao L, Yang C. TNF-?-Induced cPLA2 Expression via NADPH Oxidase/Reactive Oxygen Species-Dependent NF-?B Cascade on Human Pulmonary Alveolar Epithelial Cells. Front Pharmacol. 2016;7:447 pubmed
  30. Jung J, Ravi S, Lee D, McFadden K, Kamradt M, Toussaint L, et al. NIK/MAP3K14 Regulates Mitochondrial Dynamics and Trafficking to Promote Cell Invasion. Curr Biol. 2016;26:3288-3302 pubmed publisher
  31. Marichal T, Gaudenzio N, El Abbas S, Sibilano R, Zurek O, Starkl P, et al. Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis. J Clin Invest. 2016;126:4497-4515 pubmed publisher
  32. Chen D, Ireland S, Remington G, Alvarez E, Racke M, Greenberg B, et al. CD40-Mediated NF-?B Activation in B Cells Is Increased in Multiple Sclerosis and Modulated by Therapeutics. J Immunol. 2016;197:4257-4265 pubmed
  33. Ismail H, Didangelos A, Vincent T, Saklatvala J. Rapid Activation of Transforming Growth Factor ?-Activated Kinase 1 in Chondrocytes by Phosphorylation and K63 -Linked Polyubiquitination Upon Injury to Animal Articular Cartilage. Arthritis Rheumatol. 2017;69:565-575 pubmed publisher
  34. He Y, Yan Y, Zhang H, Lin Y, Chen Y, Yan Y, et al. Methyl salicylate 2-O-?-d-lactoside alleviates the pathological progression of pristane-induced systemic lupus erythematosus-like disease in mice via suppression of inflammatory response and signal transduction. Drug Des Devel Ther. 2016;10:3183-3196 pubmed
  35. Bettaieb A, Cremonini E, Kang H, Kang J, Haj F, Oteiza P. Anti-inflammatory actions of (-)-epicatechin in the adipose tissue of obese mice. Int J Biochem Cell Biol. 2016;81:383-392 pubmed publisher
  36. Zhou Q, Yu X, Demirkaya E, Deuitch N, Stone D, Tsai W, et al. Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease. Proc Natl Acad Sci U S A. 2016;113:10127-32 pubmed publisher
  37. Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, et al. Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis. Nat Commun. 2016;7:12547 pubmed publisher
  38. Oh B, Kim S, Lee Y, Hong H, Kim T, Kim S, et al. Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells. Oncotarget. 2016;7:57066-57076 pubmed publisher
  39. Zhou Y, Xu H, Ding Y, Lu Q, Zou M, Song P. AMPK?1 deletion in fibroblasts promotes tumorigenesis in athymic nude mice by p52-mediated elevation of erythropoietin and CDK2. Oncotarget. 2016;7:53654-53667 pubmed publisher
  40. Cameron A, Morrison V, Levin D, Mohan M, Forteath C, Beall C, et al. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circ Res. 2016;119:652-65 pubmed publisher
  41. Taminiau A, Draime A, Tys J, Lambert B, Vandeputte J, Nguyen N, et al. HOXA1 binds RBCK1/HOIL-1 and TRAF2 and modulates the TNF/NF-?B pathway in a transcription-independent manner. Nucleic Acids Res. 2016;44:7331-49 pubmed publisher
  42. Wang T, Pan D, Zhou Z, You Y, Jiang C, Zhao X, et al. Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut. PLoS Pathog. 2016;12:e1005662 pubmed publisher
  43. Kwon H, Choi G, Ryu S, Kwon S, Kim S, Booth C, et al. Stepwise phosphorylation of p65 promotes NF-?B activation and NK cell responses during target cell recognition. Nat Commun. 2016;7:11686 pubmed publisher
  44. Park S, Yi H, Suh N, Park Y, Koh J, Jeong S, et al. Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-?B. Oncotarget. 2016;7:39796-39808 pubmed publisher
  45. Emmerich C, Bakshi S, Kelsall I, Ortiz Guerrero J, Shpiro N, Cohen P. Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling. Biochem Biophys Res Commun. 2016;474:452-461 pubmed publisher
  46. Mendel I, Yacov N, Shoham A, Ishai E, Breitbart E. Treatment with Oxidized Phospholipids Directly Inhibits Nonalcoholic Steatohepatitis and Liver Fibrosis Without Affecting Steatosis. Dig Dis Sci. 2016;61:2545-53 pubmed publisher
  47. Yu Z, Chen T, Li X, Yang M, Tang S, Zhu X, et al. Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response. elife. 2016;5: pubmed publisher
  48. Starokadomskyy P, Gemelli T, Rios J, Xing C, Wang R, Li H, et al. DNA polymerase-? regulates the activation of type I interferons through cytosolic RNA:DNA synthesis. Nat Immunol. 2016;17:495-504 pubmed publisher
  49. Dang Y, Mu Y, Wang K, Xu K, Yang J, Zhu Y, et al. Papaverine inhibits lipopolysaccharide-induced microglial activation by suppressing NF-κB signaling pathway. Drug Des Devel Ther. 2016;10:851-9 pubmed publisher
  50. Acharya M, Sokolovska A, Tam J, Conway K, Stefani C, Raso F, et al. αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells. Nat Commun. 2016;7:10917 pubmed publisher
  51. Barroso González J, Auclair S, Luan S, Thomas L, Atkins K, Aslan J, et al. PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage. Cell Death Differ. 2016;23:1448-57 pubmed publisher
  52. Zhou Q, Wang H, Schwartz D, Stoffels M, Park Y, Zhang Y, et al. Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease. Nat Genet. 2016;48:67-73 pubmed publisher
  53. Varney M, Niederkorn M, Konno H, Matsumura T, Gohda J, Yoshida N, et al. Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling. J Exp Med. 2015;212:1967-85 pubmed publisher
  54. Schmidt T, Schmid Burgk J, Hornung V. Synthesis of an arrayed sgRNA library targeting the human genome. Sci Rep. 2015;5:14987 pubmed publisher
  55. Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, et al. Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA. Autophagy. 2015;11:1623-35 pubmed publisher
  56. Chen I, Hsu P, Hsu W, Chen N, Tseng P. Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation. Sci Rep. 2015;5:12300 pubmed publisher
  57. Hwang B, McCool K, Wan J, Wuerzberger Davis S, Young E, Choi E, et al. IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation. J Biol Chem. 2015;290:17967-84 pubmed publisher
  58. Boutaffala L, Bertrand M, Remouchamps C, Seleznik G, Reisinger F, Janas M, et al. NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis. Cell Death Differ. 2015;22:2020-33 pubmed publisher
  59. Boisson B, Laplantine E, Dobbs K, Cobat A, Tarantino N, Hazen M, et al. Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia. J Exp Med. 2015;212:939-51 pubmed publisher
  60. Sahu G, Farley K, El Hage N, Aiamkitsumrit B, Fassnacht R, Kashanchi F, et al. Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR. Virology. 2015;483:185-202 pubmed publisher
  61. Yang L, Zhang S, George S, Teng R, You X, Xu M, et al. Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms. Oncotarget. 2015;6:14953-69 pubmed
  62. Wang W, Huang X, Xin H, Fu M, Xue A, Wu Z. TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. J Biol Chem. 2015;290:13372-85 pubmed publisher
  63. Dong T, Li C, Wang X, Dian L, Zhang X, Li L, et al. Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine. Nat Commun. 2015;6:6522 pubmed publisher
  64. Contreras T, Ricciardi E, Cremonini E, Oteiza P. (-)-Epicatechin in the prevention of tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity. Arch Biochem Biophys. 2015;573:84-91 pubmed publisher
  65. Wu Z, Wang C, Bai M, Li X, Mei Q, Li X, et al. An LRP16-containing preassembly complex contributes to NF-κB activation induced by DNA double-strand breaks. Nucleic Acids Res. 2015;43:3167-79 pubmed publisher
  66. Kim K, Kim N, Kim S, Kim I, Kim K, Lee G. Cyclo(Phe-Pro) produced by the human pathogen Vibrio vulnificus inhibits host innate immune responses through the NF-κB pathway. Infect Immun. 2015;83:1150-61 pubmed publisher
  67. Guzmán E, Maers K, Roberts J, Kemami Wangun H, Harmody D, Wright A. The marine natural product microsclerodermin A is a novel inhibitor of the nuclear factor kappa B and induces apoptosis in pancreatic cancer cells. Invest New Drugs. 2015;33:86-94 pubmed publisher
  68. Cañeda Guzmán I, Salaiza Suazo N, Fernández Figueroa E, Carrada Figueroa G, Aguirre García M, Becker I. NK cell activity differs between patients with localized and diffuse cutaneous leishmaniasis infected with Leishmania mexicana: a comparative study of TLRs and cytokines. PLoS ONE. 2014;9:e112410 pubmed publisher
  69. Zhuang C, Sheng C, Shin W, Wu Y, Li J, Yao J, et al. A novel drug discovery strategy: mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways. Oncotarget. 2014;5:10830-9 pubmed
  70. Wu N, Huang D, Tsou H, Lin Y, Lin W. Syk mediates IL-17-induced CCL20 expression by targeting Act1-dependent K63-linked ubiquitination of TRAF6. J Invest Dermatol. 2015;135:490-498 pubmed publisher
  71. Zhao X, Zhu L, Chang Q, Jiang C, You Y, Luo T, et al. C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activation. J Biol Chem. 2014;289:30052-62 pubmed publisher
  72. Nteeba J, Ganesan S, Keating A. Progressive obesity alters ovarian folliculogenesis with impacts on pro-inflammatory and steroidogenic signaling in female mice. Biol Reprod. 2014;91:86 pubmed publisher
  73. Tang S, Chen T, Yu Z, Zhu X, Yang M, Xie B, et al. RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase. Nat Commun. 2014;5:4657 pubmed publisher
  74. Stodden G, Lindberg M, King M, Paquet M, MacLean J, Mann J, et al. Loss of Cdh1 and Trp53 in the uterus induces chronic inflammation with modification of tumor microenvironment. Oncogene. 2015;34:2471-82 pubmed publisher
  75. König H, Coughlan K, Kinsella S, Breen B, Prehn J. The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes. Neurobiol Dis. 2014;70:99-107 pubmed publisher
  76. Qian H, Shi J, Fan T, Lv J, Chen S, Song C, et al. Sophocarpine attenuates liver fibrosis by inhibiting the TLR4 signaling pathway in rats. World J Gastroenterol. 2014;20:1822-32 pubmed publisher
  77. Cheng J, Fan Y, Xu X, Dou J, Tang Y, Zhong X, et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 2014;5:e1079 pubmed publisher
  78. Olesen J, Gliemann L, Biensø R, Schmidt J, Hellsten Y, Pilegaard H. Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. J Physiol. 2014;592:1873-86 pubmed publisher
  79. Piao H, Yuan Y, Wang M, Sun Y, Liang H, Ma L. ?-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-?B signalling. Nat Cell Biol. 2014;16:245-54 pubmed publisher
  80. Zhang Q, Pan Y, Wang R, Kang L, Xue Q, Wang X, et al. Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory lesions to improve insulin signaling defect in the hypothalamus of high fructose-fed rats. J Nutr Biochem. 2014;25:420-8 pubmed publisher
  81. Bhaskar K, Maphis N, Xu G, Varvel N, Kokiko Cochran O, Weick J, et al. Microglial derived tumor necrosis factor-? drives Alzheimer's disease-related neuronal cell cycle events. Neurobiol Dis. 2014;62:273-85 pubmed publisher
  82. Hou J, Xia Y, Jiang R, Chen D, Xu J, Deng L, et al. PTPRO plays a dual role in hepatic ischemia reperfusion injury through feedback activation of NF-?B. J Hepatol. 2014;60:306-12 pubmed publisher
  83. Aoshiba K, Tsuji T, Kameyama S, Itoh M, Semba S, Yamaguchi K, et al. Senescence-associated secretory phenotype in a mouse model of bleomycin-induced lung injury. Exp Toxicol Pathol. 2013;65:1053-62 pubmed publisher
  84. Liu Y, Hawkins O, Su Y, Vilgelm A, Sobolik T, Thu Y, et al. Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-?B impairs this drug-induced senescence. EMBO Mol Med. 2013;5:149-66 pubmed publisher
  85. Journo C, Bonnet A, Favre Bonvin A, Turpin J, Vinera J, C t E, et al. Human T cell leukemia virus type 2 tax-mediated NF-?B activation involves a mechanism independent of Tax conjugation to ubiquitin and SUMO. J Virol. 2013;87:1123-36 pubmed publisher
  86. Lau R, Niu M, Pratt M. cIAP2 represses IKK?/?-mediated activation of MDM2 to prevent p53 degradation. Cell Cycle. 2012;11:4009-19 pubmed publisher
  87. Lecat A, Di Valentin E, Somja J, Jourdan S, Fillet M, Kufer T, et al. The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as a negative regulator of NOD2 protein signaling by inhibiting its oligomerization process. J Biol Chem. 2012;287:29213-26 pubmed publisher
  88. Wu L, Shao L, An N, Wang J, Pazhanisamy S, Feng W, et al. IKK? regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells. PLoS ONE. 2011;6:e18447 pubmed publisher
  89. Wan F, Weaver A, Gao X, Bern M, Hardwidge P, Lenardo M. IKK? phosphorylation regulates RPS3 nuclear translocation and NF-?B function during infection with Escherichia coli strain O157:H7. Nat Immunol. 2011;12:335-43 pubmed publisher