This is a Validated Antibody Database (VAD) review about cow CFL1, based on 43 published articles (read how Labome selects the articles), using CFL1 antibody in all methods. It is aimed to help Labome visitors find the most suited CFL1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
CFL1 synonym: cofilin-1; cofilin 1 (non-muscle); cofilin, non-muscle isoform

Knockout validation
Cell Signaling Technology
rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 6c
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3311) was used in western blot knockout validation on mouse samples (fig 6c). J Biol Chem (2018) ncbi
Cell Signaling Technology
rabbit polyclonal
  • western blot; human; loading ...; fig s2f
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3318) was used in western blot on human samples (fig s2f). Cell (2019) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig s2f
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3311) was used in western blot on human samples (fig s2f). Cell (2019) ncbi
rabbit monoclonal (77G2)
  • western blot; mouse; 1:1000; loading ...; fig 4b
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3313) was used in western blot on mouse samples at 1:1000 (fig 4b). Aging Cell (2018) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 4d
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3311) was used in western blot on human samples (fig 4d). Biochem Biophys Res Commun (2018) ncbi
rabbit polyclonal
  • western blot knockout validation; mouse; loading ...; fig 6c
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3311) was used in western blot knockout validation on mouse samples (fig 6c). J Biol Chem (2018) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 5e
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3311) was used in western blot on mouse samples at 1:1000 (fig 5e). J Exp Med (2018) ncbi
rabbit monoclonal (77G2)
  • western blot; human; 1:1000; loading ...; fig 4j
Cell Signaling Technology CFL1 antibody (Cell Signaling Technology, 3313) was used in western blot on human samples at 1:1000 (fig 4j). Nat Commun (2017) ncbi
rabbit monoclonal (77G2)
  • western blot; mouse; loading ...; fig 4b
Cell Signaling Technology CFL1 antibody (CST, 3313) was used in western blot on mouse samples (fig 4b). PLoS ONE (2017) ncbi
rabbit polyclonal
  • western blot; mouse; loading ...; fig 9a
In order to explore the role of TPM4 in platelet biogenesis, Cell Signaling Technology CFL1 antibody (Cell Signalling, 3311) was used in western blot on mouse samples (fig 9a). J Clin Invest (2017) ncbi
rabbit monoclonal (77G2)
  • western blot; mouse; loading ...; fig 4a
In order to evaluate the molecular mechanisms of how vessel wall P2Y12 mediates vascular smooth muscle cell migration and promotes the progression of atherosclerosis, Cell Signaling Technology CFL1 antibody (Cell signaling, 3313P) was used in western blot on mouse samples (fig 4a). Arterioscler Thromb Vasc Biol (2017) ncbi
rabbit monoclonal (77G2)
  • western blot; mouse; 1:1000; loading ...; fig 3g
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3313) was used in western blot on mouse samples at 1:1000 (fig 3g). J Biol Chem (2017) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 9a
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3311) was used in western blot on mouse samples at 1:1000 (fig 9a). Mol Neurobiol (2017) ncbi
rabbit monoclonal (77G2)
  • flow cytometry; human; loading ...; fig 4c
In order to suggest that persistent immune activation causes impairment of lymphocytes to respond to chemotactic stimuli, preventing their trafficking from the blood stream to peripheral organs, Cell Signaling Technology CFL1 antibody (Cell Signaling, 77G2) was used in flow cytometry on human samples (fig 4c). J Immunol (2017) ncbi
rabbit monoclonal (77G2)
  • western blot; human; 1:1000; loading ...; fig 1a
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3313) was used in western blot on human samples at 1:1000 (fig 1a). Mol Med Rep (2016) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig 3a
In order to elucidate the mechanism by which intronic hexanucleotide expansions in C9ORF72 contribute to amyotrophic lateral sclerosis, Cell Signaling Technology CFL1 antibody (Cell Signaling, 3311) was used in western blot on mouse samples at 1:1000 (fig 3a). Nat Neurosci (2016) ncbi
rabbit monoclonal (77G2)
  • western blot; human; 1:1000; fig st1
In order to identify and characterize alterations in signal transduction that occur during the development Lapatinib resistance, Cell Signaling Technology CFL1 antibody (Cell Signaling, 3313) was used in western blot on human samples at 1:1000 (fig st1). Nat Commun (2016) ncbi
rabbit monoclonal (77G2)
  • western blot; human; 1:500; loading ...; fig 2a
In order to study the contribution of cofilin in osteoblastic mechanotransduction, Cell Signaling Technology CFL1 antibody (Cell signaling, 3313) was used in western blot on human samples at 1:500 (fig 2a). Mol Med Rep (2016) ncbi
rabbit polyclonal
  • western blot; human; fig 2
In order to study a novel compound via preclinical validation that targets p70SR kinase in breast cancer, Cell Signaling Technology CFL1 antibody (Cell Signaling, 3311) was used in western blot on human samples (fig 2). Aging (Albany NY) (2016) ncbi
rabbit monoclonal (77G2)
  • western blot; human; fig 7
Cell Signaling Technology CFL1 antibody (Cell Signaling Technology, 3313) was used in western blot on human samples (fig 7). Cell Death Dis (2016) ncbi
rabbit monoclonal (77G2)
  • western blot; mouse; 1:1000; fig 4
Cell Signaling Technology CFL1 antibody (Cell Signaling Technology, 3313) was used in western blot on mouse samples at 1:1000 (fig 4). Nat Commun (2016) ncbi
rabbit monoclonal (77G2)
  • western blot; human; fig s2
In order to determine how inhibition of human glioblastoma invasion by actin polymerization can occur by an anti-depressant called fluvoxamine, Cell Signaling Technology CFL1 antibody (Cell Signaling Technology, 3313) was used in western blot on human samples (fig s2). Sci Rep (2016) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; loading ...; fig s4
In order to test if FTY720 directly alters neuronal function, Cell Signaling Technology CFL1 antibody (Cell Signaling, 3311) was used in western blot on mouse samples at 1:1000 (fig s4). Exp Neurol (2016) ncbi
rabbit monoclonal (77G2)
  • western blot; human; fig 2
In order to characterize an apical junctional complex with cytoskeletal associations and miRNA-mediated growth implications defined by PLEKHA7, Cell Signaling Technology CFL1 antibody (Cell Signaling, 3313) was used in western blot on human samples (fig 2). Cell Cycle (2016) ncbi
rabbit polyclonal
  • immunocytochemistry; human; 1:1000; loading ...; fig s3
  • western blot; human; 1:1000; loading ...; fig s3
Cell Signaling Technology CFL1 antibody (cell signalling, 3318) was used in immunocytochemistry on human samples at 1:1000 (fig s3) and in western blot on human samples at 1:1000 (fig s3). Nat Cell Biol (2016) ncbi
rabbit monoclonal (77G2)
  • western blot; human; fig 4
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3313) was used in western blot on human samples (fig 4). PLoS ONE (2015) ncbi
rabbit monoclonal (77G2)
  • western blot; human; fig s2
Cell Signaling Technology CFL1 antibody (Cell signaling, 3313) was used in western blot on human samples (fig s2). J Cell Biol (2015) ncbi
rabbit monoclonal (77G2)
  • other; mouse; 1:1000; fig s1
In order to identify host signaling dynamics upon Burkholderia spp. infection by a reverse-phase protein microarray-based screen, Cell Signaling Technology CFL1 antibody (Cell Signaling, 3313) was used in other on mouse samples at 1:1000 (fig s1). Front Microbiol (2015) ncbi
rabbit monoclonal (77G2)
  • western blot; human; fig 6
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3313) was used in western blot on human samples (fig 6). Oncotarget (2015) ncbi
rabbit monoclonal (77G2)
  • western blot; human
Cell Signaling Technology CFL1 antibody (Cell Signaling Technology, 77G2) was used in western blot on human samples . BMC Cancer (2015) ncbi
rabbit polyclonal
  • western blot; human; fig 7
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3311) was used in western blot on human samples (fig 7). PLoS ONE (2015) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000; fig s10
In order to test if extracellular signals orient the mitotic spindle of cells in the spinal cord, Cell Signaling Technology CFL1 antibody (Cell Signaling, 3311) was used in western blot on mouse samples at 1:1000 (fig s10). Nat Commun (2015) ncbi
rabbit monoclonal (77G2)
  • western blot; mouse; loading ...; fig 3a
Cell Signaling Technology CFL1 antibody (CST, 3313) was used in western blot on mouse samples (fig 3a). Cell Death Differ (2015) ncbi
rabbit polyclonal
  • western blot; human
Cell Signaling Technology CFL1 antibody (Cell Signaling Technology, 3311) was used in western blot on human samples . PLoS ONE (2015) ncbi
rabbit monoclonal (77G2)
  • western blot; human; 1:500; fig 7
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3313) was used in western blot on human samples at 1:500 (fig 7). Oncotarget (2015) ncbi
rabbit monoclonal (77G2)
  • western blot; mouse; 1:1000; fig s4
In order to study mobility of haematopoietic stem cells/progenitors through cytoskeletal dysregulation and endothelial AT2R by vasculopathy-associated hyperangiotensinemia, Cell Signaling Technology CFL1 antibody (Cell Signaling Technology, 77G2) was used in western blot on mouse samples at 1:1000 (fig s4). Nat Commun (2015) ncbi
rabbit polyclonal
  • western blot; mouse; 1:1000
Cell Signaling Technology CFL1 antibody (Cell Signaling, cs-3318) was used in western blot on mouse samples at 1:1000. J Proteome Res (2014) ncbi
rabbit polyclonal
  • immunohistochemistry; human; fig 1
  • western blot; human; fig 5
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3311) was used in immunohistochemistry on human samples (fig 1) and in western blot on human samples (fig 5). Mol Cancer Ther (2015) ncbi
rabbit monoclonal (77G2)
  • immunocytochemistry; human
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3313) was used in immunocytochemistry on human samples . Histochem Cell Biol (2014) ncbi
rabbit polyclonal
  • western blot; mouse; 1:500
In order to study the role of soluble mutant amyloid precursor protein on cognitive function and synaptic structure, Cell Signaling Technology CFL1 antibody (Cell Signaling Technology, #3311) was used in western blot on mouse samples at 1:500. J Neurosci (2014) ncbi
rabbit polyclonal
  • western blot; mouse
Cell Signaling Technology CFL1 antibody (Cell, 3311) was used in western blot on mouse samples . Neuroscience (2014) ncbi
rabbit monoclonal (77G2)
  • western blot; mouse; 1:1000
In order to study actin dynamics during podosome patterning, Cell Signaling Technology CFL1 antibody (Cell Signaling, 3313) was used in western blot on mouse samples at 1:1000. Mol Biol Cell (2014) ncbi
rabbit monoclonal (77G2)
  • western blot; human; 1:500
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3313) was used in western blot on human samples at 1:500. J Biol Chem (2013) ncbi
rabbit polyclonal
  • western blot; mouse
In order to investigate the role of ROCK1 and ROCK2 in cell detachment, Cell Signaling Technology CFL1 antibody (Cell Signaling, 3311) was used in western blot on mouse samples . Cell Death Dis (2013) ncbi
rabbit polyclonal
  • western blot; mouse
Cell Signaling Technology CFL1 antibody (Cell Signaling, 3311) was used in western blot on mouse samples . J Biol Chem (2011) ncbi
Articles Reviewed
  1. Georgouli M, Herraiz C, Crosas Molist E, Fanshawe B, Maiques O, Perdrix A, et al. Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment. Cell. 2019;176:757-774.e23 pubmed publisher
  2. Baglietto Vargas D, Prieto G, Limon A, Forner S, Rodriguez Ortiz C, Ikemura K, et al. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018;17:e12791 pubmed publisher
  3. Rondon A, de Almeida V, Gomes T, Verçoza B, Carvalho R, Konig S, et al. Tissue factor mediates microvesicles shedding from MDA-MB-231 breast cancer cells. Biochem Biophys Res Commun. 2018;502:137-144 pubmed publisher
  4. Ge J, Burnier L, Adamopoulou M, Kwa M, Schaks M, Rottner K, et al. RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells. J Biol Chem. 2018;293:9358-9369 pubmed publisher
  5. Chiang A, Fowler S, Savjani R, Hilsenbeck S, Wallace C, Cirrito J, et al. Combination anti-Aβ treatment maximizes cognitive recovery and rebalances mTOR signaling in APP mice. J Exp Med. 2018;215:1349-1364 pubmed publisher
  6. Nardone G, Oliver De La Cruz J, Vrbsky J, Martini C, Pribyl J, Skladal P, et al. YAP regulates cell mechanics by controlling focal adhesion assembly. Nat Commun. 2017;8:15321 pubmed publisher
  7. Tormos A, Rius Pérez S, Jorques M, Rada P, Ramírez L, Valverde A, et al. p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging. PLoS ONE. 2017;12:e0171738 pubmed publisher
  8. Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester Beltrán J, et al. Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia. J Clin Invest. 2017;127:814-829 pubmed publisher
  9. Niu X, Pi S, Baral S, Xia Y, He Q, Li Y, et al. P2Y12 Promotes Migration of Vascular Smooth Muscle Cells Through Cofilin Dephosphorylation During Atherogenesis. Arterioscler Thromb Vasc Biol. 2017;37:515-524 pubmed publisher
  10. Xiao Y, Ma H, Wan P, Qin D, Wang X, Zhang X, et al. Trp-Asp (WD) Repeat Domain 1 Is Essential for Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation. J Biol Chem. 2017;292:1438-1448 pubmed publisher
  11. Zimprich A, Mroz G, Meyer Zu Reckendorf C, Anastasiadou S, Förstner P, Garrett L, et al. Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms. Mol Neurobiol. 2017;54:8242-8262 pubmed publisher
  12. Cecchinato V, Bernasconi E, Speck R, Proietti M, Sauermann U, D Agostino G, et al. Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization. J Immunol. 2017;198:184-195 pubmed
  13. Lee K, Cho S, Woo S, Kim A, Lee K, Go H, et al. Danggui?Sayuk?Ga?Osuyu?Senggang?Tang ameliorates cold?induced vasoconstriction in vitro and in vivo. Mol Med Rep. 2016;14:4723-4728 pubmed publisher
  14. Sivadasan R, Hornburg D, Drepper C, Frank N, Jablonka S, Hansel A, et al. C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons. Nat Neurosci. 2016;19:1610-1618 pubmed publisher
  15. Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  16. Gao J, Fu S, Zeng Z, Li F, Niu Q, Jing D, et al. Cyclic stretch promotes osteogenesis-related gene expression in osteoblast-like cells through a cofilin-associated mechanism. Mol Med Rep. 2016;14:218-24 pubmed publisher
  17. Segatto I, Massarut S, Boyle R, Baldassarre G, Walker D, Belletti B. Preclinical validation of a novel compound targeting p70S6 kinase in breast cancer. Aging (Albany NY). 2016;8:958-76 pubmed publisher
  18. Hall A, Lu W, Godfrey J, Antonov A, Paicu C, Moxon S, et al. The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration. Cell Death Dis. 2016;7:e2184 pubmed publisher
  19. Yuan X, Cao J, He X, Serra R, Qu J, Cao X, et al. Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation. Nat Commun. 2016;7:11024 pubmed publisher
  20. Hayashi K, Michiue H, Yamada H, Takata K, Nakayama H, Wei F, et al. Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization. Sci Rep. 2016;6:23372 pubmed publisher
  21. Anastasiadou S, Knöll B. The multiple sclerosis drug fingolimod (FTY720) stimulates neuronal gene expression, axonal growth and regeneration. Exp Neurol. 2016;279:243-260 pubmed publisher
  22. Kourtidis A, Anastasiadis P. PLEKHA7 defines an apical junctional complex with cytoskeletal associations and miRNA-mediated growth implications. Cell Cycle. 2016;15:498-505 pubmed publisher
  23. Abella J, Galloni C, Pernier J, Barry D, Kjær S, Carlier M, et al. Isoform diversity in the Arp2/3 complex determines actin filament dynamics. Nat Cell Biol. 2016;18:76-86 pubmed publisher
  24. Yasuda K, Takahashi M, Mori N. Mdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its Effect on Rictor Expression. PLoS ONE. 2015;10:e0142943 pubmed publisher
  25. Hong N, Qi A, Weaver A. PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions. J Cell Biol. 2015;210:753-69 pubmed publisher
  26. Chiang C, Uzoma I, Lane D, Memišević V, Alem F, Yao K, et al. A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection. Front Microbiol. 2015;6:683 pubmed publisher
  27. Dugina V, Khromova N, Rybko V, Blizniukov O, Shagieva G, Chaponnier C, et al. Tumor promotion by γ and suppression by β non-muscle actin isoforms. Oncotarget. 2015;6:14556-71 pubmed
  28. Vaškovičová K, Szabadosová E, Čermák V, Gandalovičová A, Kasalová L, Rösel D, et al. PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness. BMC Cancer. 2015;15:326 pubmed publisher
  29. Giehl K, Keller C, Muehlich S, Goppelt Struebe M. Actin-mediated gene expression depends on RhoA and Rac1 signaling in proximal tubular epithelial cells. PLoS ONE. 2015;10:e0121589 pubmed publisher
  30. Arbeille E, Reynaud F, Sanyas I, Bozon M, Kindbeiter K, Causeret F, et al. Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis. Nat Commun. 2015;6:6366 pubmed publisher
  31. Woo J, Zhao X, Khan H, Penn C, Wang X, Joly Amado A, et al. Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers. Cell Death Differ. 2015;22:921-34 pubmed publisher
  32. Ito T, Taniguchi H, Fukagai K, Okamuro S, Kobayashi A. Inhibitory mechanism of FAT4 gene expression in response to actin dynamics during Src-induced carcinogenesis. PLoS ONE. 2015;10:e0118336 pubmed publisher
  33. Li G, Zhou J, Budhraja A, Hu X, Chen Y, Cheng Q, et al. Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis. Oncotarget. 2015;6:1834-49 pubmed
  34. Chang K, Nayak R, Roy S, Perumbeti A, Wellendorf A, Bezold K, et al. Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial ATâ‚‚R and cytoskeletal dysregulation. Nat Commun. 2015;6:5914 pubmed publisher
  35. Kararigas G, Fliegner D, Forler S, Klein O, Schubert C, Gustafsson J, et al. Comparative proteomic analysis reveals sex and estrogen receptor β effects in the pressure overloaded heart. J Proteome Res. 2014;13:5829-36 pubmed publisher
  36. Mardilovich K, Gabrielsen M, McGarry L, Orange C, Patel R, Shanks E, et al. Elevated LIM kinase 1 in nonmetastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation. Mol Cancer Ther. 2015;14:246-58 pubmed publisher
  37. Kalendová A, Kalasová I, Yamazaki S, Uličná L, Harata M, Hozak P. Nuclear actin filaments recruit cofilin and actin-related protein 3, and their formation is connected with a mitotic block. Histochem Cell Biol. 2014;142:139-52 pubmed publisher
  38. Fowler S, Chiang A, Savjani R, Larson M, Sherman M, Schuler D, et al. Genetic modulation of soluble A? rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease. J Neurosci. 2014;34:7871-85 pubmed publisher
  39. Wang H, Lewsadder M, Dorn E, Xu S, Lakshmana M. RanBP9 overexpression reduces dendritic arbor and spine density. Neuroscience. 2014;265:253-62 pubmed publisher
  40. Georgess D, Mazzorana M, Terrado J, Delprat C, Chamot C, Guasch R, et al. Comparative transcriptomics reveals RhoE as a novel regulator of actin dynamics in bone-resorbing osteoclasts. Mol Biol Cell. 2014;25:380-96 pubmed publisher
  41. Valtcheva N, Primorac A, Jurisic G, Hollmen M, Detmar M. The orphan adhesion G protein-coupled receptor GPR97 regulates migration of lymphatic endothelial cells via the small GTPases RhoA and Cdc42. J Biol Chem. 2013;288:35736-48 pubmed publisher
  42. Shi J, Wu X, Surma M, Vemula S, Zhang L, Yang Y, et al. Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment. Cell Death Dis. 2013;4:e483 pubmed publisher
  43. Maheswaranathan M, Gole H, Fernandez I, LASSEGUE B, Griendling K, San Martin A. Platelet-derived growth factor (PDGF) regulates Slingshot phosphatase activity via Nox1-dependent auto-dephosphorylation of serine 834 in vascular smooth muscle cells. J Biol Chem. 2011;286:35430-7 pubmed publisher