This is a Validated Antibody Database (VAD) review about cow CDC42, based on 17 published articles (read how Labome selects the articles), using CDC42 antibody in all methods. It is aimed to help Labome visitors find the most suited CDC42 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
CDC42 synonym: cell division control protein 42 homolog; cell division cycle 42 (GTP binding protein, 25kDa)

Knockout validation
Cell Signaling Technology
rabbit monoclonal (11A11)
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 6a
In order to elucidate the mechanisms by which filopodia clear pathogens, Cell Signaling Technology CDC42 antibody (Cell Signaling, 11A11) was used in western blot knockout validation on mouse samples at 1:1000 (fig 6a). J Biol Chem (2017) ncbi
Cell Signaling Technology
rabbit monoclonal (11A11)
  • immunohistochemistry knockout validation; mouse; 1:300; fig s1
In order to study the role of Cdc42 in foregut development and organ bud formation, Cell Signaling Technology CDC42 antibody (Cell Signaling, 2466) was used in immunohistochemistry knockout validation on mouse samples at 1:300 (fig s1). Biol Open (2016) ncbi
Cell Signaling Technology
rabbit monoclonal (11A11)
  • western blot; human; loading ...; fig 3a
Cell Signaling Technology CDC42 antibody (Cell Signaling, 2466) was used in western blot on human samples (fig 3a). J Biol Chem (2017) ncbi
rabbit monoclonal (11A11)
  • western blot; human; loading ...; fig 2b
In order to observe that chronic presence of internalized Escherichia coli leads to enhanced oncogenicity in colon cancer cells, Cell Signaling Technology CDC42 antibody (cell signalling, 2466) was used in western blot on human samples (fig 2b). Cell Death Dis (2017) ncbi
rabbit monoclonal (11A11)
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 6a
In order to elucidate the mechanisms by which filopodia clear pathogens, Cell Signaling Technology CDC42 antibody (Cell Signaling, 11A11) was used in western blot knockout validation on mouse samples at 1:1000 (fig 6a). J Biol Chem (2017) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 1i
In order to study the mechanism of internalization of CXCR4 receptor dependent on MIM and small Rab GTPases., Cell Signaling Technology CDC42 antibody (CST, 2462S) was used in western blot on human samples (fig 1i). J Cell Sci (2017) ncbi
rabbit polyclonal
  • western blot; human; 1:1000; loading ...; fig s3i
Cell Signaling Technology CDC42 antibody (Cell Signaling, 2462) was used in western blot on human samples at 1:1000 (fig s3i). J Cell Biol (2017) ncbi
rabbit monoclonal (11A11)
  • western blot; human; loading ...; fig s4a
Cell Signaling Technology CDC42 antibody (Cell signaling, 2466P) was used in western blot on human samples (fig s4a). Oncotarget (2016) ncbi
rabbit polyclonal
  • immunocytochemistry; human; loading ...; fig 4d
  • western blot; human; loading ...; fig 4c
In order to explore how extracellular translationally controlled tumor protein affects colon cancer progression, Cell Signaling Technology CDC42 antibody (Cell Signaling Technology, 2462) was used in immunocytochemistry on human samples (fig 4d) and in western blot on human samples (fig 4c). Oncotarget (2016) ncbi
rabbit monoclonal (11A11)
  • western blot; human; loading ...; fig 6c
Cell Signaling Technology CDC42 antibody (Cell Signaling, 2466) was used in western blot on human samples (fig 6c). J Biol Chem (2016) ncbi
rabbit monoclonal (11A11)
  • immunohistochemistry knockout validation; mouse; 1:300; fig s1
In order to study the role of Cdc42 in foregut development and organ bud formation, Cell Signaling Technology CDC42 antibody (Cell Signaling, 2466) was used in immunohistochemistry knockout validation on mouse samples at 1:300 (fig s1). Biol Open (2016) ncbi
rabbit monoclonal (11A11)
  • western blot; human; loading ...; fig 10e
In order to investigate the role of CD73 in endometrial cancer, Cell Signaling Technology CDC42 antibody (Cell Signaling, 11A11) was used in western blot on human samples (fig 10e). J Clin Invest (2016) ncbi
rabbit monoclonal (11A11)
  • western blot; human; loading ...; fig 2f
Cell Signaling Technology CDC42 antibody (Cell Signaling, 2466) was used in western blot on human samples (fig 2f). Sci Rep (2015) ncbi
rabbit polyclonal
  • western blot; rat; fig 4
  • western blot; human; fig 2
Cell Signaling Technology CDC42 antibody (Cell Signaling, 2462) was used in western blot on rat samples (fig 4) and in western blot on human samples (fig 2). J Am Heart Assoc (2015) ncbi
rabbit monoclonal (11A11)
  • western blot; human; 1:5000; fig 3
In order to examine the role of Cdc42 in enterocyte polarization, Cell Signaling Technology CDC42 antibody (Cell Signalling Technology, 11A11) was used in western blot on human samples at 1:5000 (fig 3). J Cell Biol (2015) ncbi
rabbit polyclonal
  • western blot; human; fig 1
Cell Signaling Technology CDC42 antibody (Cell Signaling Tech, 2462) was used in western blot on human samples (fig 1). PLoS Pathog (2015) ncbi
rabbit monoclonal (11A11)
  • western blot; rat; 1:500; fig 5
Cell Signaling Technology CDC42 antibody (Cell Signaling, 11A11) was used in western blot on rat samples at 1:500 (fig 5). Front Cell Neurosci (2015) ncbi
rabbit monoclonal (11A11)
  • western blot; human; fig s9
In order to study promotion of collective invasion by an epigenetically distinct breast cancer cell subpopulation, Cell Signaling Technology CDC42 antibody (Cell Signaling Technology, 11A11) was used in western blot on human samples (fig s9). J Clin Invest (2015) ncbi
rabbit monoclonal (11A11)
  • western blot; mouse; fig 1
Cell Signaling Technology CDC42 antibody (Cell signaling, 2466) was used in western blot on mouse samples (fig 1). Cancer Res (2014) ncbi
Articles Reviewed
  1. Juhasz A, Markel S, Gaur S, Liu H, Lu J, Jiang G, et al. NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction. J Biol Chem. 2017;292:7866-7887 pubmed publisher
  2. Sahu U, Choudhury A, Parvez S, Biswas S, Kar S. Induction of intestinal stemness and tumorigenicity by aberrant internalization of commensal non-pathogenic E. coli. Cell Death Dis. 2017;8:e2667 pubmed publisher
  3. Horsthemke M, Bachg A, Groll K, Moyzio S, Müther B, Hemkemeyer S, et al. Multiple roles of filopodial dynamics in particle capture and phagocytosis and phenotypes of Cdc42 and Myo10 deletion. J Biol Chem. 2017;292:7258-7273 pubmed publisher
  4. Li L, Baxter S, Gu N, Ji M, Zhan X. Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases. J Cell Sci. 2017;130:1475-1485 pubmed publisher
  5. Rafiq N, Lieu Z, Jiang T, Yu C, Matsudaira P, Jones G, et al. Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO. J Cell Biol. 2017;216:181-197 pubmed publisher
  6. Liu Z, Chu S, Yao S, Li Y, Fan S, Sun X, et al. CD74 interacts with CD44 and enhances tumorigenesis and metastasis via RHOA-mediated cofilin phosphorylation in human breast cancer cells. Oncotarget. 2016;7:68303-68313 pubmed publisher
  7. Xiao B, Chen D, Luo S, Hao W, Jing F, Liu T, et al. Extracellular translationally controlled tumor protein promotes colorectal cancer invasion and metastasis through Cdc42/JNK/ MMP9 signaling. Oncotarget. 2016;7:50057-50073 pubmed publisher
  8. Wynn M, Yates J, Evans C, Van Wassenhove L, Wu Z, Bridges S, et al. RhoC GTPase Is a Potent Regulator of Glutamine Metabolism and N-Acetylaspartate Production in Inflammatory Breast Cancer Cells. J Biol Chem. 2016;291:13715-29 pubmed publisher
  9. Loebel D, Plageman T, Tang T, Jones V, Muccioli M, Tam P. Thyroid bud morphogenesis requires CDC42- and SHROOM3-dependent apical constriction. Biol Open. 2016;5:130-9 pubmed publisher
  10. Bowser J, Blackburn M, Shipley G, Molina J, Dunner K, Broaddus R. Loss of CD73-mediated actin polymerization promotes endometrial tumor progression. J Clin Invest. 2016;126:220-38 pubmed publisher
  11. Shrivastava A, Prasad A, Kuzontkoski P, Yu J, Groopman J. Slit2N Inhibits Transmission of HIV-1 from Dendritic Cells to T-cells by Modulating Novel Cytoskeletal Elements. Sci Rep. 2015;5:16833 pubmed publisher
  12. Yu D, Makkar G, Strickland D, Blanpied T, Stumpo D, Blackshear P, et al. Myristoylated Alanine-Rich Protein Kinase Substrate (MARCKS) Regulates Small GTPase Rac1 and Cdc42 Activity and Is a Critical Mediator of Vascular Smooth Muscle Cell Migration in Intimal Hyperplasia Formation. J Am Heart Assoc. 2015;4:e002255 pubmed publisher
  13. Bruurs L, Donker L, Zwakenberg S, Zwartkruis F, Begthel H, Knisely A, et al. ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization. J Cell Biol. 2015;210:1055-63 pubmed publisher
  14. Gramolelli S, Weidner Glunde M, Abere B, Viejo Borbolla A, Bala K, Rückert J, et al. Inhibiting the Recruitment of PLCγ1 to Kaposi's Sarcoma Herpesvirus K15 Protein Reduces the Invasiveness and Angiogenesis of Infected Endothelial Cells. PLoS Pathog. 2015;11:e1005105 pubmed publisher
  15. Bijata M, Wlodarczyk J, Figiel I. Dystroglycan controls dendritic morphogenesis of hippocampal neurons in vitro. Front Cell Neurosci. 2015;9:199 pubmed publisher
  16. Westcott J, Prechtl A, Maine E, Dang T, Esparza M, Sun H, et al. An epigenetically distinct breast cancer cell subpopulation promotes collective invasion. J Clin Invest. 2015;125:1927-43 pubmed publisher
  17. Sakamori R, Yu S, Zhang X, Hoffman A, Sun J, Das S, et al. CDC42 inhibition suppresses progression of incipient intestinal tumors. Cancer Res. 2014;74:5480-92 pubmed publisher