This is a Validated Antibody Database (VAD) review about chicken TARDBP, based on 36 published articles (read how Labome selects the articles), using TARDBP antibody in all methods. It is aimed to help Labome visitors find the most suited TARDBP antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
TARDBP synonym: TAR DNA-binding protein 43; TDP-43

Knockout validation
Proteintech Group
rabbit polyclonal
  • immunohistochemistry knockout validation; mouse; 1:500; loading ...; fig 1b
In order to ask if nuclear depletion of TDP-43 contributes to Alzheimer's disease pathogenesis, Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in immunohistochemistry knockout validation on mouse samples at 1:500 (fig 1b). Acta Neuropathol (2016) ncbi
Proteintech Group
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:5000; loading ...; fig s8
  • immunocytochemistry; human; 1:1000; loading ...; fig 1e
  • western blot; human; 1:1000; loading ...; fig 1d
Proteintech Group TARDBP antibody (ProteinTech, 10782-2-AP) was used in immunohistochemistry - paraffin section on human samples at 1:5000 (fig s8), in immunocytochemistry on human samples at 1:1000 (fig 1e) and in western blot on human samples at 1:1000 (fig 1d). Nat Neurosci (2019) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 9c
Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in immunohistochemistry - paraffin section on mouse samples (fig 9c). J Neurosci (2018) ncbi
rabbit polyclonal
  • immunocytochemistry; rat; loading ...; fig 8a
  • western blot; rat; 1:1000; loading ...; fig 8b
Proteintech Group TARDBP antibody (Proteintech, 1078-2-AP) was used in immunocytochemistry on rat samples (fig 8a) and in western blot on rat samples at 1:1000 (fig 8b). Sci Rep (2018) ncbi
rabbit polyclonal
  • immunocytochemistry; rat; loading ...; fig 1a
Proteintech Group TARDBP antibody (ProteinTech, 10782-2-AP) was used in immunocytochemistry on rat samples (fig 1a). Sci Rep (2017) ncbi
rabbit polyclonal
  • immunohistochemistry; human; 1:100; loading ...; fig s3b
In order to show that expression of human TDP-43 impairs small interfering RNA silencing, the major post-transcriptional mechanism of retrotransposable element control in somatic tissue, Proteintech Group TARDBP antibody (Protein Tech, 10782-2-AP) was used in immunohistochemistry on human samples at 1:100 (fig s3b). PLoS Genet (2017) ncbi
rabbit polyclonal
  • immunocytochemistry; human; 1:500; loading ...; fig 3a
  • western blot; human; 1:5000; loading ...; fig 4a
Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in immunocytochemistry on human samples at 1:500 (fig 3a) and in western blot on human samples at 1:5000 (fig 4a). Front Mol Neurosci (2017) ncbi
rabbit polyclonal
  • immunocytochemistry; human; fig s9d
Proteintech Group TARDBP antibody (Proteintech, 1078-2-AP) was used in immunocytochemistry on human samples (fig s9d). PLoS Genet (2017) ncbi
rabbit polyclonal
  • immunohistochemistry knockout validation; mouse; 1:500; loading ...; fig 1b
In order to ask if nuclear depletion of TDP-43 contributes to Alzheimer's disease pathogenesis, Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in immunohistochemistry knockout validation on mouse samples at 1:500 (fig 1b). Acta Neuropathol (2016) ncbi
rabbit polyclonal
  • immunocytochemistry; human; loading ...; fig 5a
In order to report the interactome of all dipeptide repeat proteins, Proteintech Group TARDBP antibody (Proteintech Group, 10782-2-AP) was used in immunocytochemistry on human samples (fig 5a). Cell (2016) ncbi
rabbit polyclonal
  • immunocytochemistry; human; 1:500; loading ...; fig 5c
In order to investigate if amyotrophic lateral sclerosis is a prion-like disorder, Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in immunocytochemistry on human samples at 1:500 (fig 5c). Neurobiol Dis (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:2000; fig 6d
Proteintech Group TARDBP antibody (Proteintech, 10782) was used in western blot on human samples at 1:2000 (fig 6d). Nat Commun (2016) ncbi
rabbit polyclonal
  • immunoprecipitation; mouse; fig 1
  • western blot; mouse; 1:1000; fig 1
Proteintech Group TARDBP antibody (ProteinTech, 10782-2-AP) was used in immunoprecipitation on mouse samples (fig 1) and in western blot on mouse samples at 1:1000 (fig 1). PLoS Genet (2016) ncbi
rabbit polyclonal
  • immunohistochemistry; mouse; 1:100
Proteintech Group TARDBP antibody (Proteintech, 107822AP) was used in immunohistochemistry on mouse samples at 1:100. Hum Mol Genet (2016) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; fig 1
In order to assess the correlation with levels of phosphotau and autophagy-related proteins and tau inclusions in PSP, Pick, and AD disease and levels of a key component of clathrin-mediated endocytosis, PICALM, Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in immunohistochemistry - paraffin section on human samples (fig 1). Neurobiol Dis (2016) ncbi
rabbit polyclonal
  • western blot; human; 1:500; fig 5
Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in western blot on human samples at 1:500 (fig 5). Acta Neuropathol Commun (2016) ncbi
rabbit polyclonal
  • immunocytochemistry; human; fig 8
  • western blot; human; fig 3
Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in immunocytochemistry on human samples (fig 8) and in western blot on human samples (fig 3). Mol Neurodegener (2016) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s3g
In order to research the role of C9orf72 in macrophage and microglial function, Proteintech Group TARDBP antibody (ProteinTech, 10782-2-AP) was used in immunohistochemistry - paraffin section on mouse samples (fig s3g). Science (2016) ncbi
rabbit polyclonal
  • western blot; mouse; 1:10,000; fig 6
In order to learn about induction of selective motor neuron degeneration through toxic gain of function due to ALS-associated mutant FUS, Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in western blot on mouse samples at 1:10,000 (fig 6). Nat Commun (2016) ncbi
rabbit polyclonal
  • western blot; baker's yeast; fig 3
In order to investigate mechanisms of Hsp104 potentiation, Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in western blot on baker's yeast samples (fig 3). J Biol Chem (2016) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; fig 7
Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in immunohistochemistry - paraffin section on human samples (fig 7). Sci Rep (2015) ncbi
rabbit polyclonal
  • western blot; human; 1:500; fig 4
In order to report that the DNAJB6 mutation, Pro96Arg, caused a distal-onset myopathy in one family, Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in western blot on human samples at 1:500 (fig 4). Acta Neuropathol Commun (2015) ncbi
rabbit polyclonal
  • immunohistochemistry; human; 1:10,000; fig s5
In order to report the neuropathologic autopsy findings of a man with the rare Tyr69His transthyretin gene variant, Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in immunohistochemistry on human samples at 1:10,000 (fig s5). Acta Neuropathol Commun (2015) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; loading ...; fig 5
Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in immunohistochemistry - paraffin section on human samples (fig 5). Acta Neuropathol (2015) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; human; 1:100; fig s3
In order to identify gene variants that contribute to amyotrophic lateral sclerosis, Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in immunohistochemistry - paraffin section on human samples at 1:100 (fig s3). Nat Neurosci (2015) ncbi
rabbit polyclonal
  • western blot; human; loading ...; fig 9
Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in western blot on human samples (fig 9). Ann Clin Transl Neurol (2015) ncbi
rabbit polyclonal
  • immunocytochemistry; human; 1:400
  • western blot; human; 1:6000
In order to study the effect of loss of Transactive response DNA-binding protein 43 on the proteome, Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in immunocytochemistry on human samples at 1:400 and in western blot on human samples at 1:6000. Neuroscience (2015) ncbi
rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; 1:500
  • western blot; mouse; 1:1000
Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in immunohistochemistry - frozen section on mouse samples at 1:500 and in western blot on mouse samples at 1:1000. Neurobiol Aging (2015) ncbi
rabbit polyclonal
  • immunocytochemistry; human; 1:200; fig 4
  • western blot; human; fig 3
Proteintech Group TARDBP antibody (ProteinTech, 10782-2-AP) was used in immunocytochemistry on human samples at 1:200 (fig 4) and in western blot on human samples (fig 3). PLoS Genet (2014) ncbi
rabbit polyclonal
  • immunocytochemistry; human
  • western blot; human
Proteintech Group TARDBP antibody (Protein Tech, 10782-2-AP) was used in immunocytochemistry on human samples and in western blot on human samples . Hum Mol Genet (2015) ncbi
rabbit polyclonal
  • western blot; rat
  • western blot; human; 1:1000
  • western blot; mouse; 1:1000
Proteintech Group TARDBP antibody (ProteinTech Group, 10782-2-AP) was used in western blot on rat samples , in western blot on human samples at 1:1000 and in western blot on mouse samples at 1:1000. J Cereb Blood Flow Metab (2014) ncbi
rabbit polyclonal
  • immunohistochemistry - paraffin section; human
Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in immunohistochemistry - paraffin section on human samples . Brain (2014) ncbi
rabbit polyclonal
  • western blot; mouse; 1:2000
Proteintech Group TARDBP antibody (ProteinTech Group, 10782-2-AP) was used in western blot on mouse samples at 1:2000. PLoS ONE (2014) ncbi
rabbit polyclonal
  • western blot; human; fig 8
Proteintech Group TARDBP antibody (Abnova , 10782-2-AP) was used in western blot on human samples (fig 8). Biochim Biophys Acta (2014) ncbi
rabbit polyclonal
  • immunohistochemistry; fruit fly; 1:50; fig 10
  • western blot; fruit fly; fig 3
Proteintech Group TARDBP antibody (Proteintech, 10782-2-AP) was used in immunohistochemistry on fruit fly samples at 1:50 (fig 10) and in western blot on fruit fly samples (fig 3). PLoS ONE (2013) ncbi
rabbit polyclonal
  • immunocytochemistry; mouse; fig 4
  • immunohistochemistry - paraffin section; human; fig 6
  • immunocytochemistry; human; fig 1
  • western blot; human; fig 2
In order to study the role of loss of spliceosome integrity in the development of amyotrophic lateral sclerosis and spinal muscular atrophy, Proteintech Group TARDBP antibody (ProteinTech, 10782-2-AP) was used in immunocytochemistry on mouse samples (fig 4), in immunohistochemistry - paraffin section on human samples (fig 6), in immunocytochemistry on human samples (fig 1) and in western blot on human samples (fig 2). EMBO Mol Med (2013) ncbi
Novus Biologicals
rabbit polyclonal
  • immunohistochemistry - frozen section; mouse; 1:100; fig 5a
Novus Biologicals TARDBP antibody (Novus Biologicals, NB110-55376) was used in immunohistochemistry - frozen section on mouse samples at 1:100 (fig 5a). Dis Model Mech (2017) ncbi
Articles Reviewed
  1. Melamed Z, López Erauskin J, Baughn M, Zhang O, Drenner K, Sun Y, et al. Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration. Nat Neurosci. 2019;22:180-190 pubmed publisher
  2. Kuliyev E, Gingras S, Guy C, Howell S, Vogel P, Pelletier S. Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability. J Neurosci. 2018;38:2615-2630 pubmed publisher
  3. Gemechu J, Sharma A, Yu D, Xie Y, Merkel O, Moszczynska A. Characterization of Dopaminergic System in the Striatum of Young Adult Park2-/- Knockout Rats. Sci Rep. 2018;8:1517 pubmed publisher
  4. Herzog J, Deshpande M, Shapiro L, Rodal A, Paradis S. TDP-43 misexpression causes defects in dendritic growth. Sci Rep. 2017;7:15656 pubmed publisher
  5. Krug L, Chatterjee N, Borges Monroy R, Hearn S, Liao W, Morrill K, et al. Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS. PLoS Genet. 2017;13:e1006635 pubmed publisher
  6. Wobst H, Wesolowski S, Chadchankar J, Delsing L, Jacobsen S, Mukherjee J, et al. Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro. Front Mol Neurosci. 2017;10:46 pubmed publisher
  7. Shadle S, Zhong J, Campbell A, Conerly M, Jagannathan S, Wong C, et al. DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy. PLoS Genet. 2017;13:e1006658 pubmed publisher
  8. Kobayashi M, Chandrasekhar A, Cheng C, Martinez J, Ng H, de La Hoz C, et al. Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22. Dis Model Mech. 2017;10:215-224 pubmed publisher
  9. Laclair K, Donde A, Ling J, Jeong Y, Chhabra R, Martin L, et al. Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model. Acta Neuropathol. 2016;132:859-873 pubmed
  10. Lee K, Zhang P, Kim H, Mitrea D, Sarkar M, Freibaum B, et al. C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Cell. 2016;167:774-788.e17 pubmed publisher
  11. Smethurst P, Newcombe J, Troakes C, Simone R, Chen Y, Patani R, et al. In vitro prion-like behaviour of TDP-43 in ALS. Neurobiol Dis. 2016;96:236-247 pubmed publisher
  12. Kapeli K, Pratt G, Vu A, Hutt K, Martinez F, Sundararaman B, et al. Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses. Nat Commun. 2016;7:12143 pubmed publisher
  13. Li R, Dong Q, Yuan X, Zeng X, Gao Y, Chiao C, et al. Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome. PLoS Genet. 2016;12:e1006129 pubmed publisher
  14. Vernay A, Therreau L, Blot B, Risson V, Dirrig Grosch S, Waegaert R, et al. A transgenic mouse expressing CHMP2Bintron5 mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia. Hum Mol Genet. 2016;25:3341-3360 pubmed publisher
  15. Ando K, Tomimura K, Sazdovitch V, Suain V, Yilmaz Z, Authelet M, et al. Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease. Neurobiol Dis. 2016;94:32-43 pubmed publisher
  16. Onesto E, Colombrita C, Gumina V, Borghi M, Dusi S, Doretti A, et al. Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts. Acta Neuropathol Commun. 2016;4:47 pubmed publisher
  17. Alquezar C, Salado I, de la Encarnación A, Perez D, Moreno F, Gil C, et al. Targeting TDP-43 phosphorylation by Casein Kinase-1? inhibitors: a novel strategy for the treatment of frontotemporal dementia. Mol Neurodegener. 2016;11:36 pubmed publisher
  18. O Rourke J, Bogdanik L, Yáñez A, Lall D, Wolf A, Muhammad A, et al. C9orf72 is required for proper macrophage and microglial function in mice. Science. 2016;351:1324-9 pubmed publisher
  19. Sharma A, Lyashchenko A, Lu L, Nasrabady S, Elmaleh M, Mendelsohn M, et al. ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function. Nat Commun. 2016;7:10465 pubmed publisher
  20. Torrente M, Chuang E, Noll M, Jackrel M, Go M, Shorter J. Mechanistic Insights into Hsp104 Potentiation. J Biol Chem. 2016;291:5101-15 pubmed publisher
  21. Farrawell N, Lambert Smith I, Warraich S, Blair I, Saunders D, Hatters D, et al. Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions. Sci Rep. 2015;5:13416 pubmed publisher
  22. Ruggieri A, Brancati F, Zanotti S, Maggi L, Pasanisi M, Saredi S, et al. Complete loss of the DNAJB6 G/F domain and novel missense mutations cause distal-onset DNAJB6 myopathy. Acta Neuropathol Commun. 2015;3:44 pubmed publisher
  23. Ziskin J, Greicius M, Zhu W, Okumu A, Adams C, Plowey E. Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia. Acta Neuropathol Commun. 2015;3:43 pubmed publisher
  24. Cooper Knock J, Higginbottom A, Stopford M, Highley J, Ince P, Wharton S, et al. Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy. Acta Neuropathol. 2015;130:63-75 pubmed publisher
  25. Freischmidt A, Wieland T, Richter B, Ruf W, Schaeffer V, Müller K, et al. Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. Nat Neurosci. 2015;18:631-6 pubmed publisher
  26. Homma S, Beermann M, BOYCE F, Miller J. Expression of FSHD-related DUX4-FL alters proteostasis and induces TDP-43 aggregation. Ann Clin Transl Neurol. 2015;2:151-66 pubmed publisher
  27. Å talekar M, Yin X, Rebolj K, Darovic S, Troakes C, Mayr M, et al. Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport. Neuroscience. 2015;293:157-70 pubmed publisher
  28. Liu Y, Atkinson R, Fernandez Martos C, Kirkcaldie M, Cui H, Vickers J, et al. Changes in TDP-43 expression in development, aging, and in the neurofilament light protein knockout mouse. Neurobiol Aging. 2015;36:1151-9 pubmed publisher
  29. Zhang T, Baldie G, Periz G, Wang J. RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response. PLoS Genet. 2014;10:e1004693 pubmed publisher
  30. Budini M, Romano V, Quadri Z, Buratti E, Baralle F. TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domain. Hum Mol Genet. 2015;24:9-20 pubmed publisher
  31. Yang Z, Lin F, Robertson C, Wang K. Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury. J Cereb Blood Flow Metab. 2014;34:1444-52 pubmed publisher
  32. Cooper Knock J, Walsh M, Higginbottom A, Robin Highley J, Dickman M, Edbauer D, et al. Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions. Brain. 2014;137:2040-51 pubmed publisher
  33. Perera N, Sheean R, Scott J, Kemp B, Horne M, Turner B. Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models. PLoS ONE. 2014;9:e90449 pubmed publisher
  34. De Marco G, Lomartire A, Mandili G, Lupino E, Buccinnà B, Ramondetti C, et al. Reduced cellular Ca(2+) availability enhances TDP-43 cleavage by apoptotic caspases. Biochim Biophys Acta. 2014;1843:725-34 pubmed publisher
  35. Zhan L, Hanson K, Kim S, Tare A, Tibbetts R. Identification of genetic modifiers of TDP-43 neurotoxicity in Drosophila. PLoS ONE. 2013;8:e57214 pubmed publisher
  36. Tsuiji H, Iguchi Y, Furuya A, Kataoka A, Hatsuta H, Atsuta N, et al. Spliceosome integrity is defective in the motor neuron diseases ALS and SMA. EMBO Mol Med. 2013;5:221-34 pubmed publisher