This is a Validated Antibody Database (VAD) review about chicken SPTAN1, based on 24 published articles (read how Labome selects the articles), using SPTAN1 antibody in all methods. It is aimed to help Labome visitors find the most suited SPTAN1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
SPTAN1 synonym: SPECA; spectrin alpha chain, non-erythrocytic 1; alpha-II spectrin; alpha-spectrin; fodrin alpha chain; nonerythroid alpha-spectrin; spectrin alpha chain, brain; spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); spectrin, non-erythroid alpha chain

EMD Millipore
mouse monoclonal (AA6)
  • western blot; human; fig 3
EMD Millipore SPTAN1 antibody (Merck KGaA, MAB1622) was used in western blot on human samples (fig 3). Acta Neuropathol Commun (2016) ncbi
mouse monoclonal (AA6)
  • western blot; mouse; fig s1
In order to analyze delay of neurodegeneration by preventing stress-induced OPA1 processing in mitochondria by loss of OMA1, EMD Millipore SPTAN1 antibody (Merck Millipore, MAB1622) was used in western blot on mouse samples (fig s1). J Cell Biol (2016) ncbi
mouse monoclonal (AA6)
  • immunohistochemistry - frozen section; mouse; 1:50; fig 8
In order to investigate the developmental processes that regulate the formation of unique inner ear cell types, EMD Millipore SPTAN1 antibody (Millipore, MAB1622) was used in immunohistochemistry - frozen section on mouse samples at 1:50 (fig 8). Nat Commun (2015) ncbi
mouse monoclonal (AA6)
  • western blot; rat; 1:1000
EMD Millipore SPTAN1 antibody (Merck Millipore, MAB1622) was used in western blot on rat samples at 1:1000. Cell Death Dis (2015) ncbi
mouse monoclonal (AA6)
  • western blot; mouse; 1:500; fig 6
EMD Millipore SPTAN1 antibody (Millipore, MAB1622) was used in western blot on mouse samples at 1:500 (fig 6). elife (2015) ncbi
mouse monoclonal (AA6)
  • immunoprecipitation; human
In order to study the interaction between BRCA1 tumor suppressor and inositol 1,4,5-trisphosphate receptors and its effect on apoptotic calcium release, EMD Millipore SPTAN1 antibody (Millipore, MAB1622) was used in immunoprecipitation on human samples . J Biol Chem (2015) ncbi
mouse monoclonal (AA6)
  • western blot; mouse
In order to explore the role of calcium handling in SCA28 pathogenesis, EMD Millipore SPTAN1 antibody (EMD Millipore, MAB1622) was used in western blot on mouse samples . J Clin Invest (2015) ncbi
mouse monoclonal (AA6)
  • western blot; rat
EMD Millipore SPTAN1 antibody (Chemicon, MAB1622) was used in western blot on rat samples . Brain Behav Immun (2015) ncbi
mouse monoclonal (AA6)
  • western blot; mouse; 1:1000; fig 3
In order to study vascular endothelial growth factor signaling in mice infected with Plasmodium berghei ANKA, EMD Millipore SPTAN1 antibody (Millipore, MAB1622) was used in western blot on mouse samples at 1:1000 (fig 3). Front Immunol (2014) ncbi
mouse monoclonal (AA6)
  • western blot; rat
EMD Millipore SPTAN1 antibody (Millipore, 1622) was used in western blot on rat samples . PLoS ONE (2014) ncbi
mouse monoclonal (AA6)
  • western blot; human; 1:40000
EMD Millipore SPTAN1 antibody (Millipore, MAB1622) was used in western blot on human samples at 1:40000. J Biol Chem (2014) ncbi
mouse monoclonal (AA6)
  • western blot; mouse; 1:1000
EMD Millipore SPTAN1 antibody (Millipore, MAB1622) was used in western blot on mouse samples at 1:1000. J Neurosci (2014) ncbi
mouse monoclonal (AA6)
  • western blot; human
EMD Millipore SPTAN1 antibody (Chemicon International, MAB1622) was used in western blot on human samples . Infect Immun (2014) ncbi
mouse monoclonal (AA6)
  • immunoprecipitation; human
  • western blot; human
EMD Millipore SPTAN1 antibody (Millipore, MAB1622) was used in immunoprecipitation on human samples and in western blot on human samples . Mol Cancer (2014) ncbi
mouse monoclonal (AA6)
  • western blot; rat
EMD Millipore SPTAN1 antibody (Chemicon, MAB1622) was used in western blot on rat samples . Neuropsychopharmacology (2014) ncbi
mouse monoclonal (AA6)
  • western blot; mouse
In order to study the roles of calpain-1 and calpain-2 in murine aortic aneurysms induced by angiotensin II, EMD Millipore SPTAN1 antibody (Chemicon-EMD Millipore, MAB1622) was used in western blot on mouse samples . PLoS ONE (2013) ncbi
mouse monoclonal (AA6)
  • western blot; rat
EMD Millipore SPTAN1 antibody (Millipore, MAB1622) was used in western blot on rat samples . Exp Neurol (2013) ncbi
mouse monoclonal (AA6)
  • western blot; mouse; 1:5,000
In order to study the involvement of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemia, EMD Millipore SPTAN1 antibody (Millipore, MAB1622) was used in western blot on mouse samples at 1:5,000. J Cereb Blood Flow Metab (2013) ncbi
mouse monoclonal (AA6)
  • western blot; human; 1:5000; fig 2
In order to study the ability of pharmacological activation of AMPK to protect a human neuroblastoma cell line against homocysteine-induced toxicity, EMD Millipore SPTAN1 antibody (Chemicon, MAB1622) was used in western blot on human samples at 1:5000 (fig 2). Neurochem Res (2013) ncbi
mouse monoclonal (AA6)
  • western blot; rat; 1:5000
EMD Millipore SPTAN1 antibody (Millipore, MAB1622) was used in western blot on rat samples at 1:5000. J Biol Chem (2013) ncbi
mouse monoclonal (AA6)
  • western blot; rat; 1:10000
In order to study the role of calpain-regulated p35/cdk5 in the mechanism by which the PDE5 inhibitor sildenafil protects against malonate-induced chemical hypoxia, EMD Millipore SPTAN1 antibody (Chemicon, MAB1622) was used in western blot on rat samples at 1:10000. Biochim Biophys Acta (2013) ncbi
mouse monoclonal (AA6)
  • western blot; mouse; 1:5000
EMD Millipore SPTAN1 antibody (Millipore, MAB1622) was used in western blot on mouse samples at 1:5000. J Cereb Blood Flow Metab (2013) ncbi
mouse monoclonal (AA6)
  • western blot; rat; 1:1000
EMD Millipore SPTAN1 antibody (Chemicon, mab1622) was used in western blot on rat samples at 1:1000. J Comp Neurol (2008) ncbi
mouse monoclonal (AA6)
  • western blot; rat
EMD Millipore SPTAN1 antibody (Chemicon, mab-1622) was used in western blot on rat samples . J Neurosci (2005) ncbi
Articles Reviewed
  1. Kurbatskaya K, Phillips E, Croft C, Dentoni G, Hughes M, Wade M, et al. Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain. Acta Neuropathol Commun. 2016;4:34 pubmed publisher
  2. Korwitz A, Merkwirth C, Richter Dennerlein R, Tröder S, Sprenger H, Quirós P, et al. Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol. 2016;212:157-66 pubmed publisher
  3. Burns J, Kelly M, Hoa M, Morell R, Kelley M. Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear. Nat Commun. 2015;6:8557 pubmed publisher
  4. Curcio M, Salazar I, Inácio A, Duarte E, Canzoniero L, Duarte C. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons. Cell Death Dis. 2015;6:e1645 pubmed publisher
  5. Altmeppen H, Prox J, Krasemann S, Puig B, Kruszewski K, Dohler F, et al. The sheddase ADAM10 is a potent modulator of prion disease. elife. 2015;4: pubmed publisher
  6. Hedgepeth S, Garcia M, Wagner L, Rodriguez A, Chintapalli S, Snyder R, et al. The BRCA1 tumor suppressor binds to inositol 1,4,5-trisphosphate receptors to stimulate apoptotic calcium release. J Biol Chem. 2015;290:7304-13 pubmed publisher
  7. Maltecca F, Baseggio E, Consolato F, Mazza D, Podini P, Young S, et al. Purkinje neuron Ca2+ influx reduction rescues ataxia in SCA28 model. J Clin Invest. 2015;125:263-74 pubmed publisher
  8. Zang Y, Chen S, Liao G, Zhu H, Wei X, Cui Y, et al. Calpain-2 contributes to neuropathic pain following motor nerve injury via up-regulating interleukin-6 in DRG neurons. Brain Behav Immun. 2015;44:37-47 pubmed publisher
  9. Hempel C, Hoyer N, Kildemoes A, Jendresen C, Kurtzhals J. Systemic and Cerebral Vascular Endothelial Growth Factor Levels Increase in Murine Cerebral Malaria along with Increased Calpain and Caspase Activity and Can be Reduced by Erythropoietin Treatment. Front Immunol. 2014;5:291 pubmed publisher
  10. Fernandes J, Vieira M, Carreto L, Santos M, Duarte C, Carvalho A, et al. In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons. PLoS ONE. 2014;9:e99958 pubmed publisher
  11. Sánchez Osuna M, García Belinchón M, Iglesias Guimarais V, Gil Guiñón E, Casanelles E, Yuste V. Caspase-activated DNase is necessary and sufficient for oligonucleosomal DNA breakdown, but not for chromatin disassembly during caspase-dependent apoptosis of LN-18 glioblastoma cells. J Biol Chem. 2014;289:18752-69 pubmed publisher
  12. Stein L, Wozniak D, Dearborn J, Kubota S, Apte R, Izumi Y, et al. Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function. J Neurosci. 2014;34:5800-15 pubmed publisher
  13. Navarro Garcia F, Serapio Palacios A, Vidal J, Salazar M, Tapia Pastrana G. EspC promotes epithelial cell detachment by enteropathogenic Escherichia coli via sequential cleavages of a cytoskeletal protein and then focal adhesion proteins. Infect Immun. 2014;82:2255-65 pubmed publisher
  14. Hinrichsen I, Ernst B, Nuber F, Passmann S, Schäfer D, Steinke V, et al. Reduced migration of MLH1 deficient colon cancer cells depends on SPTAN1. Mol Cancer. 2014;13:11 pubmed publisher
  15. Halpin L, Northrop N, Yamamoto B. Ammonia mediates methamphetamine-induced increases in glutamate and excitotoxicity. Neuropsychopharmacology. 2014;39:1031-8 pubmed publisher
  16. Subramanian V, Moorleghen J, Balakrishnan A, Howatt D, Chishti A, Uchida H. Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice. PLoS ONE. 2013;8:e72214 pubmed publisher
  17. Liu L, Martin R, Kohler G, Chan C. Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytes. Exp Neurol. 2013;248:482-90 pubmed publisher
  18. Yoshioka H, Katsu M, Sakata H, Okami N, Wakai T, Kinouchi H, et al. The role of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemia. J Cereb Blood Flow Metab. 2013;33:1658-65 pubmed publisher
  19. Park Y, Ko J, Jang Y, Kwon Y. Activation of AMP-activated protein kinase alleviates homocysteine-mediated neurotoxicity in SH-SY5Y cells. Neurochem Res. 2013;38:1561-71 pubmed publisher
  20. Huang Q, Wang H, Perry S, Figueiredo Pereira M. Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons. J Biol Chem. 2013;288:12161-74 pubmed publisher
  21. Barros Miñones L, Martín de Saavedra D, Perez Alvarez S, Orejana L, Suquía V, Goni Allo B, et al. Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate. Biochim Biophys Acta. 2013;1832:705-17 pubmed publisher
  22. Okami N, Narasimhan P, Yoshioka H, Sakata H, Kim G, Jung J, et al. Prevention of JNK phosphorylation as a mechanism for rosiglitazone in neuroprotection after transient cerebral ischemia: activation of dual specificity phosphatase. J Cereb Blood Flow Metab. 2013;33:106-14 pubmed publisher
  23. Papadeas S, Halloran C, McCown T, Breese G, Blake B. Changes in apical dendritic structure correlate with sustained ERK1/2 phosphorylation in medial prefrontal cortex of a rat model of dopamine D1 receptor agonist sensitization. J Comp Neurol. 2008;511:271-85 pubmed publisher
  24. Beier C, Wischhusen J, Gleichmann M, Gerhardt E, Pekanovic A, Krueger A, et al. FasL (CD95L/APO-1L) resistance of neurons mediated by phosphatidylinositol 3-kinase-Akt/protein kinase B-dependent expression of lifeguard/neuronal membrane protein 35. J Neurosci. 2005;25:6765-74 pubmed