This is a Validated Antibody Database (VAD) review about chicken CAV1, based on 45 published articles (read how Labome selects the articles), using CAV1 antibody in all methods. It is aimed to help Labome visitors find the most suited CAV1 antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
CAV1 synonym: caveolin-1

Knockout validation
BD Biosciences
mouse monoclonal (2297/Caveolin 1)
  • western blot knockout validation; mouse; loading ...; fig 3b
  • western blot; human; fig 1a
BD Biosciences CAV1 antibody (BD Transduction Laboratories, 610406) was used in western blot knockout validation on mouse samples (fig 3b) and in western blot on human samples (fig 1a). Mol Cells (2015) ncbi
BD Biosciences
mouse monoclonal (2297/Caveolin 1)
  • western blot; human; fig 1
  • western blot knockout validation; mouse; fig 1
BD Biosciences CAV1 antibody (BD, 610406) was used in western blot on human samples (fig 1) and in western blot knockout validation on mouse samples (fig 1). J Biol Chem (2012) ncbi
BD Biosciences
mouse monoclonal (2297/Caveolin 1)
  • immunohistochemistry knockout validation; mouse; 1:100; fig 1
In order to investigate the functions of nNOS in mouse small intestinal smooth muscle, BD Biosciences CAV1 antibody (BD Transduction Labs, 610,406) was used in immunohistochemistry knockout validation on mouse samples at 1:100 (fig 1). J Cell Mol Med (2008) ncbi
Invitrogen
domestic rabbit polyclonal
  • immunocytochemistry; human; loading ...; fig 7a
In order to study the pro-angiogenic effect and cellular uptake of fucoidans from Ascophyllum nodosum, Invitrogen CAV1 antibody (Pierce, PA5-17447) was used in immunocytochemistry on human samples (fig 7a). Mar Drugs (2016) ncbi
BD Biosciences
mouse monoclonal (2297/Caveolin 1)
  • immunohistochemistry - free floating section; mouse; 1:50; loading ...; fig s4a
BD Biosciences CAV1 antibody (BD Biosciences, 610407) was used in immunohistochemistry - free floating section on mouse samples at 1:50 (fig s4a). Theranostics (2022) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; human; loading ...; fig 4d
BD Biosciences CAV1 antibody (BD Biosciences, 610406) was used in western blot on human samples (fig 4d). Sci Rep (2021) ncbi
mouse monoclonal (2297/Caveolin 1)
  • immunohistochemistry; mouse; fig 1b
  • western blot; mouse; fig 1a
BD Biosciences CAV1 antibody (BD Biosciences, 610407) was used in immunohistochemistry on mouse samples (fig 1b) and in western blot on mouse samples (fig 1a). Mol Brain (2021) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; mouse; 1:500; loading ...; fig 1c, 1d
BD Biosciences CAV1 antibody (BD Biosciences, 2297) was used in western blot on mouse samples at 1:500 (fig 1c, 1d). elife (2020) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; human; 1:2000; loading ...; fig 1a
BD Biosciences CAV1 antibody (BD, 610406) was used in western blot on human samples at 1:2000 (fig 1a). Sci Rep (2019) ncbi
mouse monoclonal (2297/Caveolin 1)
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig s4d
BD Biosciences CAV1 antibody (BD Biosciences, 610406) was used in immunohistochemistry - frozen section on mouse samples at 1:100 (fig s4d). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; mouse; 1:1000; loading ...; fig 3c
BD Biosciences CAV1 antibody (BD Transduction Lab, 610406) was used in western blot on mouse samples at 1:1000 (fig 3c). J Biol Chem (2017) ncbi
mouse monoclonal (2297/Caveolin 1)
  • immunohistochemistry; mouse; loading ...
BD Biosciences CAV1 antibody (BD Transduction lab, 610406) was used in immunohistochemistry on mouse samples . Dis Model Mech (2017) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; mouse; loading ...; fig 2a
In order to find that the Glu/Asp transporter SLC1A3 is localized to the plasma membrane and the major regulator of acidic amino acid uptake in adipocytes, BD Biosciences CAV1 antibody (BD Transduction, 610407) was used in western blot on mouse samples (fig 2a). FEBS Lett (2017) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; human; loading ...; fig 1d
BD Biosciences CAV1 antibody (BD Transduction Laboratories, 610406) was used in western blot on human samples (fig 1d). J Biol Chem (2016) ncbi
mouse monoclonal (2297/Caveolin 1)
  • immunocytochemistry; mouse; 1:200; fig 6
BD Biosciences CAV1 antibody (BD Biosciences, 610406) was used in immunocytochemistry on mouse samples at 1:200 (fig 6). Biochim Biophys Acta (2016) ncbi
mouse monoclonal (2234/Caveolin 1)
  • immunocytochemistry; human; 1:200; fig 1
  • western blot; human; fig 1
  • immunocytochemistry; mouse; 1:200; fig s1
BD Biosciences CAV1 antibody (BD Biosciences, 610493) was used in immunocytochemistry on human samples at 1:200 (fig 1), in western blot on human samples (fig 1) and in immunocytochemistry on mouse samples at 1:200 (fig s1). J Clin Invest (2016) ncbi
mouse monoclonal (2297/Caveolin 1)
  • immunohistochemistry; dogs; 5 ug/ml; fig 5
In order to study how the role of increased caveolin-1 can help with repair to intervertebral disc degeneration, BD Biosciences CAV1 antibody (BD Biosciences, 610406) was used in immunohistochemistry on dogs samples at 5 ug/ml (fig 5). Arthritis Res Ther (2016) ncbi
mouse monoclonal (2234/Caveolin 1)
  • western blot; human; 1:1000; fig 3
In order to investigate the dysfunction found in mitochondria in fibroblasts received from patients with Niemann-Pick type C disease, BD Biosciences CAV1 antibody (BD Transduction Laboratories, 610494) was used in western blot on human samples at 1:1000 (fig 3). Arch Biochem Biophys (2016) ncbi
mouse monoclonal (2234/Caveolin 1)
  • other; human; loading ...; fig st1
In order to use size exclusion chromatography-microsphere-based affinity proteomics to study clinical samples obtained from pediatric acute leukemia patients, BD Biosciences CAV1 antibody (BD, 2234) was used in other on human samples (fig st1). Mol Cell Proteomics (2016) ncbi
mouse monoclonal (2297/Caveolin 1)
  • immunocytochemistry; human; 1:20; loading ...; fig 3b
  • western blot; human; 1:500; loading ...; fig 2a
In order to demonstrate that receptor tyrosine kinase-like orphan receptor 1 is a scaffold for cavin-1 and caveolin-1, BD Biosciences CAV1 antibody (BD Bioscience, 610407) was used in immunocytochemistry on human samples at 1:20 (fig 3b) and in western blot on human samples at 1:500 (fig 2a). Nat Commun (2016) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; human; 1:1000; fig 5C
BD Biosciences CAV1 antibody (BD, 610406) was used in western blot on human samples at 1:1000 (fig 5C). PLoS ONE (2015) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot knockout validation; mouse; loading ...; fig 3b
  • western blot; human; fig 1a
BD Biosciences CAV1 antibody (BD Transduction Laboratories, 610406) was used in western blot knockout validation on mouse samples (fig 3b) and in western blot on human samples (fig 1a). Mol Cells (2015) ncbi
mouse monoclonal (2297/Caveolin 1)
  • immunocytochemistry; human; loading ...; fig s5b
BD Biosciences CAV1 antibody (BD Bioscience, 610406) was used in immunocytochemistry on human samples (fig s5b). Traffic (2016) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; human; fig 5c
BD Biosciences CAV1 antibody (BD Transduction lab, 610407) was used in western blot on human samples (fig 5c). Int J Obes (Lond) (2016) ncbi
mouse monoclonal (2234/Caveolin 1)
  • western blot; human; fig 2
In order to analyze sensitivity to the cyclin D1/CDK4 pathway inhibition in Ewing sarcoma by a chemical genomic, functional, and super-enhancer screening, BD Biosciences CAV1 antibody (BD Transduction Lab, 610493) was used in western blot on human samples (fig 2). Oncotarget (2015) ncbi
mouse monoclonal (2297/Caveolin 1)
  • immunocytochemistry; human; fig 4
  • western blot; human; fig 5
BD Biosciences CAV1 antibody (BD Transduction Laboratories, 610407) was used in immunocytochemistry on human samples (fig 4) and in western blot on human samples (fig 5). Oncotarget (2015) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; human
In order to investigate flotillin-1-mediated regulation of insulin-like growth factor-1 signaling, BD Biosciences CAV1 antibody (BD, 610406) was used in western blot on human samples . J Cell Sci (2015) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; human; fig 2
In order to show that fatty acylated cav-2 is a IR tyrosine kinase substrate during insulin signaling, BD Biosciences CAV1 antibody (BD, 610406) was used in western blot on human samples (fig 2). Biochim Biophys Acta (2015) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; African green monkey; loading ...; fig 3c
  • western blot; human; loading ...; fig 7b
BD Biosciences CAV1 antibody (BD Transduction Laboratories, 610406) was used in western blot on African green monkey samples (fig 3c) and in western blot on human samples (fig 7b). Traffic (2015) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; human
In order to study the roll of cell surface heparan sulfate proteoglycans in relation to cell adhesion, BD Biosciences CAV1 antibody (BD Biosciences, 610406) was used in western blot on human samples . Mol Cancer (2015) ncbi
mouse monoclonal (2234/Caveolin 1)
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 4
BD Biosciences CAV1 antibody (BD Biosciences, 610493) was used in immunohistochemistry - paraffin section on mouse samples at 1:100 (fig 4). elife (2014) ncbi
mouse monoclonal (2297/Caveolin 1)
  • immunohistochemistry - frozen section; rat; 1:250; fig 1
  • western blot; rat; 1:2000; fig 4
In order to study the ultrastructural and immunohistochemical changes of inner and outer portions of colonic circular muscle in rats treated with otilonium bromide chronically, BD Biosciences CAV1 antibody (BD Transduction Labs, 610406) was used in immunohistochemistry - frozen section on rat samples at 1:250 (fig 1) and in western blot on rat samples at 1:2000 (fig 4). PLoS ONE (2014) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; human
BD Biosciences CAV1 antibody (BD Biosciences, 610407) was used in western blot on human samples . Arch Pharm Res (2015) ncbi
mouse monoclonal (2297/Caveolin 1)
  • immunohistochemistry - frozen section; chicken
In order to localize and characterize cholesterol-rich membrane microdomains in the inner ear, BD Biosciences CAV1 antibody (BD Transduction, 610406) was used in immunohistochemistry - frozen section on chicken samples . J Proteomics (2014) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; mouse; 1:10,000
BD Biosciences CAV1 antibody (BD Transduction laboratories, 610407) was used in western blot on mouse samples at 1:10,000. PLoS ONE (2014) ncbi
mouse monoclonal (2297/Caveolin 1)
  • immunohistochemistry - frozen section; rat; 1:100
In order to study HIF-1alpha mediated metabolic switching and mitochondrial remodeling in bladder outlet obstruction, BD Biosciences CAV1 antibody (BD Transduction Laboratories, 610407) was used in immunohistochemistry - frozen section on rat samples at 1:100. Lab Invest (2014) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; African green monkey
BD Biosciences CAV1 antibody (BD Transduction Laboratories, 610406) was used in western blot on African green monkey samples . J Biol Chem (2014) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; mouse
BD Biosciences CAV1 antibody (BD Transduction laboratories, 610407) was used in western blot on mouse samples . Physiol Rep (2013) ncbi
mouse monoclonal (2234/Caveolin 1)
  • immunocytochemistry; mouse; 1:250
BD Biosciences CAV1 antibody (Becton Dickinson, 610493) was used in immunocytochemistry on mouse samples at 1:250. Genes Dev (2013) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; mouse; fig 4
BD Biosciences CAV1 antibody (BD, 610406) was used in western blot on mouse samples (fig 4). Autophagy (2014) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; human
BD Biosciences CAV1 antibody (BD Transduction Laboratories, 610406) was used in western blot on human samples . J Biol Chem (2013) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; human
BD Biosciences CAV1 antibody (BD Bioscience, 610407) was used in western blot on human samples . J Cell Sci (2013) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; human
BD Biosciences CAV1 antibody (BD Transduction Laboratories, 610406) was used in western blot on human samples . Cell Cycle (2013) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; human
In order to study the inhibition of tumor growth caused by mitochondrial dysfunction in the epithelial cancer cell compartment, BD Biosciences CAV1 antibody (BD Transduction Laboratories, 610407) was used in western blot on human samples . Cell Cycle (2013) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; mouse
BD Biosciences CAV1 antibody (BD Biosciences, 2297) was used in western blot on mouse samples . Eur J Pharmacol (2013) ncbi
mouse monoclonal (2297/Caveolin 1)
  • western blot; human; fig 1
  • western blot knockout validation; mouse; fig 1
BD Biosciences CAV1 antibody (BD, 610406) was used in western blot on human samples (fig 1) and in western blot knockout validation on mouse samples (fig 1). J Biol Chem (2012) ncbi
mouse monoclonal (2297/Caveolin 1)
  • immunohistochemistry - frozen section; rat
BD Biosciences CAV1 antibody (BD Transduction Laboratories, 610406) was used in immunohistochemistry - frozen section on rat samples . J Comp Neurol (2012) ncbi
mouse monoclonal (2297/Caveolin 1)
  • immunohistochemistry knockout validation; mouse; 1:100; fig 1
In order to investigate the functions of nNOS in mouse small intestinal smooth muscle, BD Biosciences CAV1 antibody (BD Transduction Labs, 610,406) was used in immunohistochemistry knockout validation on mouse samples at 1:100 (fig 1). J Cell Mol Med (2008) ncbi
Articles Reviewed
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  2. Lin C, Huang P, Chen C, Wu M, Chen J, Chen J, et al. Sitagliptin attenuates arterial calcification by downregulating oxidative stress-induced receptor for advanced glycation end products in LDLR knockout mice. Sci Rep. 2021;11:17851 pubmed publisher
  3. Ha T, Choi Y, Noh H, Cha S, Kim J, Park S. Age-related increase in caveolin-1 expression facilitates cell-to-cell transmission of α-synuclein in neurons. Mol Brain. 2021;14:122 pubmed publisher
  4. Ded L, Hwang J, Miki K, Shi H, Chung J. 3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice. elife. 2020;9: pubmed publisher
  5. Rangel L, Bernabé Rubio M, Fernández Barrera J, Casares Arias J, Millan J, Alonso M, et al. Caveolin-1α regulates primary cilium length by controlling RhoA GTPase activity. Sci Rep. 2019;9:1116 pubmed publisher
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  7. Song Z, Xiaoli A, Zhang Q, Zhang Y, Yang E, Wang S, et al. Cyclin C regulates adipogenesis by stimulating transcriptional activity of CCAAT/enhancer-binding protein ?. J Biol Chem. 2017;292:8918-8932 pubmed publisher
  8. Otis J, Shen M, Quinlivan V, Anderson J, Farber S. Intestinal epithelial cell caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels. Dis Model Mech. 2017;10:283-295 pubmed publisher
  9. Krycer J, Fazakerley D, Cater R, C Thomas K, Naghiloo S, Burchfield J, et al. The amino acid transporter, SLC1A3, is plasma membrane-localised in adipocytes and its activity is insensitive to insulin. FEBS Lett. 2017;591:322-330 pubmed publisher
  10. Parag Sharma K, Leyme A, DiGiacomo V, Marivin A, Broselid S, Garcia Marcos M. Membrane Recruitment of the Non-receptor Protein GIV/Girdin (G?-interacting, Vesicle-associated Protein/Girdin) Is Sufficient for Activating Heterotrimeric G Protein Signaling. J Biol Chem. 2016;291:27098-27111 pubmed publisher
  11. Marinval N, Saboural P, Haddad O, Maire M, Bassand K, Geinguenaud F, et al. Identification of a Pro-Angiogenic Potential and Cellular Uptake Mechanism of a LMW Highly Sulfated Fraction of Fucoidan from Ascophyllum nodosum. Mar Drugs. 2016;14: pubmed
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  13. Kim D, Bynoe M. A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier. J Clin Invest. 2016;126:1717-33 pubmed publisher
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  18. Lin C, Huang P, Lai C, Chen J, Lin S, Chen J. Simvastatin Attenuates Oxidative Stress, NF-κB Activation, and Artery Calcification in LDLR-/- Mice Fed with High Fat Diet via Down-regulation of Tumor Necrosis Factor-α and TNF Receptor 1. PLoS ONE. 2015;10:e0143686 pubmed publisher
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  20. Albecka A, Laine R, Janssen A, Kaminski C, Crump C. HSV-1 Glycoproteins Are Delivered to Virus Assembly Sites Through Dynamin-Dependent Endocytosis. Traffic. 2016;17:21-39 pubmed publisher
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  23. Moon H, Ruelcke J, Choi E, Sharpe L, Nassar Z, Bielefeldt Ohmann H, et al. Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1. Oncotarget. 2015;6:7438-53 pubmed
  24. Jang D, Kwon H, Jeong K, Lee J, Pak Y. Essential role of flotillin-1 palmitoylation in the intracellular localization and signaling function of IGF-1 receptor. J Cell Sci. 2015;128:2179-90 pubmed publisher
  25. Kwon H, Lee J, Jeong K, Jang D, Pak Y. Fatty acylated caveolin-2 is a substrate of insulin receptor tyrosine kinase for insulin receptor substrate-1-directed signaling activation. Biochim Biophys Acta. 2015;1853:1022-34 pubmed publisher
  26. Han B, Tiwari A, Kenworthy A. Tagging strategies strongly affect the fate of overexpressed caveolin-1. Traffic. 2015;16:417-38 pubmed publisher
  27. Lim H, Multhaupt H, Couchman J. Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells. Mol Cancer. 2015;14:15 pubmed publisher
  28. Ye R, Holland W, Gordillo R, Wang M, Wang Q, Shao M, et al. Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration. elife. 2014;3: pubmed publisher
  29. Traini C, Faussone Pellegrini M, Evangelista S, Mazzaferro K, Cipriani G, Santicioli P, et al. Inner and outer portions of colonic circular muscle: ultrastructural and immunohistochemical changes in rat chronically treated with otilonium bromide. PLoS ONE. 2014;9:e103237 pubmed publisher
  30. Yang H, Hwangbo K, Zheng M, Cho J, Son J, Kim H, et al. Inhibitory effects of (-)-loliolide on cellular senescence in human dermal fibroblasts. Arch Pharm Res. 2015;38:876-84 pubmed publisher
  31. Thomas P, Cheng A, Colby C, Liu L, Patel C, Josephs L, et al. Localization and proteomic characterization of cholesterol-rich membrane microdomains in the inner ear. J Proteomics. 2014;103:178-93 pubmed publisher
  32. Swärd K, Albinsson S, Rippe C. Arterial dysfunction but maintained systemic blood pressure in cavin-1-deficient mice. PLoS ONE. 2014;9:e92428 pubmed publisher
  33. Ekman M, Uvelius B, Albinsson S, Swärd K. HIF-mediated metabolic switching in bladder outlet obstruction mitigates the relaxing effect of mitochondrial inhibition. Lab Invest. 2014;94:557-68 pubmed publisher
  34. Wehmeyer L, Du Toit A, Lang D, Hapgood J. Lipid raft- and protein kinase C-mediated synergism between glucocorticoid- and gonadotropin-releasing hormone signaling results in decreased cell proliferation. J Biol Chem. 2014;289:10235-51 pubmed publisher
  35. Swärd K, Sadegh M, Mori M, Erjefalt J, Rippe C. Elevated pulmonary arterial pressure and altered expression of Ddah1 and Arg1 in mice lacking cavin-1/PTRF. Physiol Rep. 2013;1:e00008 pubmed publisher
  36. Nakayama A, Nakayama M, Turner C, Höing S, Lepore J, Adams R. Ephrin-B2 controls PDGFR? internalization and signaling. Genes Dev. 2013;27:2576-89 pubmed publisher
  37. Tan S, Shui G, Zhou J, Shi Y, Huang J, Xia D, et al. Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway. Autophagy. 2014;10:226-42 pubmed publisher
  38. Linderoth E, Pilia G, Mahajan N, Ferby I. Activated Cdc42-associated kinase 1 (Ack1) is required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor recruitment to lipid rafts and induction of cell death. J Biol Chem. 2013;288:32922-31 pubmed publisher
  39. Barceló C, Paco N, Beckett A, Alvarez Moya B, Garrido E, Gelabert M, et al. Oncogenic K-ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status. J Cell Sci. 2013;126:4553-9 pubmed publisher
  40. Avena P, Anselmo W, Whitaker Menezes D, Wang C, Pestell R, Lamb R, et al. Compartment-specific activation of PPAR? governs breast cancer tumor growth, via metabolic reprogramming and symbiosis. Cell Cycle. 2013;12:1360-70 pubmed publisher
  41. Sánchez Alvarez R, Martinez Outschoorn U, Lamb R, Hulit J, Howell A, Gandara R, et al. Mitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin. Cell Cycle. 2013;12:172-82 pubmed publisher
  42. Rahman A, Ekman M, Shakirova Y, Andersson K, Morgelin M, Erjefalt J, et al. Late onset vascular dysfunction in the R6/1 model of Huntington's disease. Eur J Pharmacol. 2013;698:345-53 pubmed publisher
  43. Li W, Liu H, Zhou J, Cao J, Zhou X, Choi A, et al. Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2). J Biol Chem. 2012;287:20922-30 pubmed publisher
  44. Takahashi Iwanaga H, Iwanaga T. Accumulated caveolae constitute subcellular compartments for glial calcium signaling in lanceolate sensory endings innervating rat vibrissae. J Comp Neurol. 2012;520:2053-66 pubmed publisher
  45. El Yazbi A, Cho W, Cena J, Schulz R, Daniel E. Smooth muscle NOS, colocalized with caveolin-1, modulates contraction in mouse small intestine. J Cell Mol Med. 2008;12:1404-15 pubmed publisher