This is a Validated Antibody Database (VAD) review about Domestic g.. Cacna1s, based on 11 published articles (read how Labome selects the articles), using Cacna1s antibody in all methods. It is aimed to help Labome visitors find the most suited Cacna1s antibody. Please note the number of articles fluctuates since newly identified citations are added and citations for discontinued catalog numbers are removed regularly.
Cacna1s synonym: voltage-dependent L-type calcium channel subunit alpha-1S

Invitrogen
mouse monoclonal (1A)
  • western blot; mouse; 1:1000; loading ...; fig s2f
In order to elucidate the mechanism by which the I4895T mutation in the type 1 ryanodine receptor/Ca(2+) release channel results in disease, Invitrogen Cacna1s antibody (Thermo Scientific, MA3-920) was used in western blot on mouse samples at 1:1000 (fig s2f). Nat Commun (2017) ncbi
mouse monoclonal (1A)
  • western blot; human; 1:2000; loading ...; fig 1b
In order to determine the role of calcium regulation in sporadic inclusion body myositis, Invitrogen Cacna1s antibody (Thermo Fischer, MA3-920) was used in western blot on human samples at 1:2000 (fig 1b). Acta Neuropathol Commun (2017) ncbi
mouse monoclonal (1A)
  • western blot; mouse; loading ...; fig 2e
In order to report the physiological role of sarcolipin upregulation in muscle myopathy, Invitrogen Cacna1s antibody (Pierce Antibodies, MA3-920) was used in western blot on mouse samples (fig 2e). PLoS ONE (2017) ncbi
mouse monoclonal (1A)
  • immunohistochemistry; zebrafish ; 1:100; loading ...; fig 1a
In order to analyze critical roles for Stac3 in excitation-contraction coupling and human disease, Invitrogen Cacna1s antibody (Thermo, MA3-920) was used in immunohistochemistry on zebrafish samples at 1:100 (fig 1a). Proc Natl Acad Sci U S A (2017) ncbi
mouse monoclonal (1A)
  • western blot; rat; 1:1000; loading ...; fig 5a
In order to report the effects of eccentric contraction on calpain-dependent proteolysis of calcium ion-regulatory proteins and force production in fast-twitch skeletal muscles, Invitrogen Cacna1s antibody (ThermoFisher Scientific, MA3-920) was used in western blot on rat samples at 1:1000 (fig 5a). J Appl Physiol (1985) (2017) ncbi
mouse monoclonal (1A)
  • western blot; mouse; 1:1000; fig 6
In order to report the mechanism by which thrombospondin-4 regulates skeletal muscle integrity, Invitrogen Cacna1s antibody (Thermo Fisher Scientific, MA3-920) was used in western blot on mouse samples at 1:1000 (fig 6). elife (2016) ncbi
mouse monoclonal (1A)
  • western blot; mouse; fig 13
In order to learn the importance to growth, calcium release, and fiber composition from the sarcoplasmic reticulum in postnatal skeletal muscle from cysteine-rich domain 3 (Stac3) gene and SH3, Invitrogen Cacna1s antibody (ThermoFisher Scientific, 1A) was used in western blot on mouse samples (fig 13). Skelet Muscle (2016) ncbi
mouse monoclonal (1A)
  • western blot; mouse; 1:1000; fig 5, 6
In order to analyze how Serpina3n overexpression halts muscular dystrophy in mice, Invitrogen Cacna1s antibody (Pierce, MA3-920) was used in western blot on mouse samples at 1:1000 (fig 5, 6). Hum Mol Genet (2016) ncbi
mouse monoclonal (1A)
  • immunohistochemistry; mouse; 1:100
In order to study the role of vesicle trafficking and cytoskeletal reorganization in the mechanism by which EHD1 mediates normal muscle development, Invitrogen Cacna1s antibody (Pierce, MA3-920) was used in immunohistochemistry on mouse samples at 1:100. Dev Biol (2014) ncbi
mouse monoclonal (1A)
  • immunohistochemistry; mouse
In order to assess how deregulation of the protocadherin gene FAT1 changes muscle shape implying a role for the pathogenesis of facioscapulohumeral dystrophy, Invitrogen Cacna1s antibody (Thermo scientific, MA3-920) was used in immunohistochemistry on mouse samples . PLoS Genet (2013) ncbi
mouse monoclonal (1A)
  • western blot; human
In order to investigate the abnormalities of calcium handling proteins in skeletal and heart muscle during heart failure, Invitrogen Cacna1s antibody (Pierce, 1A) was used in western blot on human samples . J Card Fail (2012) ncbi
Articles Reviewed
  1. Lee C, Hanna A, Wang H, Dagnino Acosta A, Joshi A, Knoblauch M, et al. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017;8:14659 pubmed publisher
  2. Amici D, Pinal Fernández I, Mázala D, Lloyd T, Corse A, Christopher Stine L, et al. Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis. Acta Neuropathol Commun. 2017;5:24 pubmed publisher
  3. Fajardo V, Gamu D, Mitchell A, Bloemberg D, Bombardier E, Chambers P, et al. Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice. PLoS ONE. 2017;12:e0173708 pubmed publisher
  4. Linsley J, Hsu I, Groom L, Yarotskyy V, Lavorato M, Horstick E, et al. Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3. Proc Natl Acad Sci U S A. 2017;114:E228-E236 pubmed publisher
  5. Kanzaki K, Watanabe D, Kuratani M, Yamada T, Matsunaga S, Wada M. Role of calpain in eccentric contraction-induced proteolysis of Ca2+-regulatory proteins and force depression in rat fast-twitch skeletal muscle. J Appl Physiol (1985). 2017;122:396-405 pubmed publisher
  6. Vanhoutte D, Schips T, Kwong J, Davis J, Tjondrokoesoemo A, Brody M, et al. Thrombospondin expression in myofibers stabilizes muscle membranes. elife. 2016;5: pubmed publisher
  7. Cong X, Doering J, Mázala D, Chin E, Grange R, Jiang H. The SH3 and cysteine-rich domain 3 (Stac3) gene is important to growth, fiber composition, and calcium release from the sarcoplasmic reticulum in postnatal skeletal muscle. Skelet Muscle. 2016;6:17 pubmed publisher
  8. Tjondrokoesoemo A, Schips T, Kanisicak O, Sargent M, Molkentin J. Genetic overexpression of Serpina3n attenuates muscular dystrophy in mice. Hum Mol Genet. 2016;25:1192-202 pubmed publisher
  9. Posey A, Swanson K, Alvarez M, Krishnan S, Earley J, Band H, et al. EHD1 mediates vesicle trafficking required for normal muscle growth and transverse tubule development. Dev Biol. 2014;387:179-90 pubmed publisher
  10. Caruso N, Herberth B, Bartoli M, Puppo F, Dumonceaux J, Zimmermann A, et al. Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of facioscapulohumeral dystrophy. PLoS Genet. 2013;9:e1003550 pubmed publisher
  11. Middlekauff H, Vigna C, Verity M, Fonarow G, Horwich T, Hamilton M, et al. Abnormalities of calcium handling proteins in skeletal muscle mirror those of the heart in humans with heart failure: a shared mechanism?. J Card Fail. 2012;18:724-33 pubmed publisher