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Alomone Labs Celecoxib blocks L-type CaVchannel currents expressed inXenopusoocytes. - A. Time course of CaV1.2 (co-expressed with ?2?1 and ?1 auxiliary subunits) currents elicited by 100 ms voltage ramp from holding potential of -100 mV to +50 mV delivered every 10 seconds. Application of 100 MCelecoxib(#C-190) inhibits the current amplitude (period of application indicated by horizontal bar). B. Representative current traces before and during application of 100 M Celecoxib as indicated.
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