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Alomone Labs Bupivacaine hydrochloride blocks NaV1.2 channels expressed inXenopusoocytes. - A. Time course of NaV1.2 current amplitude showing inhibition by 10 M and 50 MBupivacaine hydrochloride(#B-125). Currents were elicited by a 100 ms voltage step from holding potential of -70 mV to 0 mV applied every 10 seconds.B. Superimposed current traces from A at application of control 10 M and 50 M Bupivacaine hydrochloride (as indicated).
Alomone Labs Frescolat MGA activates TRPM8 channels expressed in HEK-293 cells. - Dose response curve of the activation of TRPM8 shown as relative fluorescence plotted against increasing concentrations ofFrescolat MGA(#F-165). EC50was determined at 1.77 M. Cells were loaded with Calcium-5 dye. Changes in intracellular Ca2+following agonist application were detected as changes in 485 nm/525 nm fluorescence (RFU).
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