antibody

Anti-IFN alpha In Vivo Antibody - Ultra Low Endotoxin (TIF-3C5) [ICH1135UL] ichorbio

ICH1135UL

5 mg

312 GBP

monoclonal

hamsters

nonconjugated

TIF-3C5

ICH1135UL

Anti-IFN alpha In Vivo Antibody - Ultra Low Endotoxin (TIF-3C5) [ICH1135UL] ichorbio

Anti-IFN alpha In Vivo Antibody - Ultra Low Endotoxin (TIF-3C5) [ICH1135UL]

Bulk anti-IFN alpha In Vivo Antibody - Ultra Low Endotoxin (TIF-3C5)

ichorbio's anti-IFN alpha In Vivo Antibody - Ultra Low Endotoxin (TIF-3C5) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. This means that ichorbio's ultra low-endoxin antibodies have the lowest endotoxin in the industry at less than 0.75 EU/mg. The purity of ichorbio's ultra low endotoxin antibodies are unsurpassed at >98% and they are all pathogen tested and third-party certified by IDEXX BioReseach of meet the lowest mycoplasma specification and free of any viral pathogens of concern. ichorbio offers Amazon vouchers or donations to the NC3Rs for reviews of this product: click here for more information. ichorbio: the best antibodies for in vivo research.

IFN alpha

TIF-3C5

5 mg

312 GBP

25mg

832

50mg

1352

100mg

2080

Armenian Hamster IgG1

IFNa, interferon alpha

Armenian Hamster

Mouse

≥ 2.0 mg/ml

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.

>98% by SDS-PAGE and HPLC

≤ 0.75 EU/mg as determined by the LAL method

Aggregation level ≤ 1%

We use the IMPACT test generated by IDEXX Laboratories to guarantee our Ultra Low Endotoxin antibodies are pathogen free. Our hamster antibodies are tested for: Mycoplasma spp Mycoplasma pulmonis Pneumonia virus of mice Kilham's rat virus Toolan's H1 virus Hamster parvovirus Lymphocytic choriomeningitis Minute virus of mice Theiler's murine encephalomyelitis virus Sendai virus Reovirus 3 Hantaan virus

anti-IFN alpha In Vivo Antibody - Ultra Low Endotoxin (TIF-3C5) is stable when stored at 2-8°C. For long-term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Western Blot, Functional Assays

Functional Assay: In vitro activity of TIF-3C5 - inhibits IFNalpha -induced (IFNalpha-A, -1, -4, -5, -11 and 13) Stat1 phosphorylation in vitro. [TIF-1D6 does not block in vitro functional activity]. - blocks IFNA (IFNA-A, -1, -4, -5, -11 and 13) induction of MHC-I expression (H2-Kb) using L929 or fibrosarcoma cell lines in a dose dependent manner. - neutralizes IFNA-induced antiviral activity in vitro following infection of L929 cells with VSV. Functional activity of both recombinant (IFNalpha-A, -1, -4, -5, -11 and 13) and natural IFNalpha can be blocked with no neutralization of IFNgor IFNb. In vivo activity of TIF-3C5 - TIF-3C5 circulates with a half-life of 4 days - blockade of IFNa by TIF-3C5 increases the lethality of mice infected with West Nile Virus (WNV), similar to susceptibility of Irf7-/- mice. Each investigator should determine their own optimal working dilution for specific applications.

Armenian Hamster IgG Isotype Control for In Vivo - Ultra Low Endotoxin [PIP] (ICH2251UL)

Anti-IFN alpha In Vivo Antibody - Low Endotoxin [TIF-3C5] (ICH1135)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

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