Anti-IL-6 In Vivo Antibody - Low Endotoxin (MP5-20F3) [ICH1126] ichorbio

product summary

company name :

ichorbio

product type :

antibody

product name :

Anti-IL-6 In Vivo Antibody - Low Endotoxin (MP5-20F3) [ICH1126] ichorbio

catalog :

ICH1126

quantity :

0.5 mg

price :

160 GBP

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

MP5-20F3

reactivity :

mouse

application :

ELISA, neutralization

more info or order :

ichorbio product webpage

product information

Product Type :

Low Endotoxin

ichorbio Cat Number :

ICH1126

Page Title :

Anti-IL-6 In Vivo Antibody - Low Endotoxin (MP5-20F3) [ICH1126] ichorbio

Page Heading :

Anti-IL-6 In Vivo Antibody - Low Endotoxin (MP5-20F3) [ICH1126]

Page Heading :

Bulk anti-IL-6 In Vivo Antibody - Low Endotoxin (MP5-20F3)

Product Benefits :

ichorbio's anti-IL-6 In Vivo Antibody - Low Endotoxin (MP5-20F3) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. ichorbio's low endotoxin antibodies have half the endotoxin of comparable antibodies from our competitors at less than 1.0 EU/mg. If ichorbio's low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin ( here for more information. ichorbio: the best antibodies for in vivo research.

Target :

IL-6

Clone :

MP5-20F3

Size1 :

0.5 mg

Academic Price1 :

160 GBP

Isotype :

Rat IgG1

Other names :

Interleukin-6, IL-6, B-cell hybridoma growth factor, Interleukin HP-1

UniProt :

P08505

Host :

Rat

Species Reactivity :

Mouse

Specificity :

Anti-IL-6 In Vivo Antibody - Low Endotoxin (MP5-20F3) recognizes an epitope on Mouse IL-6

Purification method :

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background :

Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6 is also a "myokine," a cytokine produced from muscle, and is elevated in response to muscle contraction. It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. Additionally, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10. IL16 has been shown to suppress the replication of HIV and SIV.

Concentration :

1.0 mg/ml

Formulation :

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.

Purity :

>95% by SDS-PAGE and HPLC

Endotoxin :

<0.1 EU/mg as determined by the LAL method

Aggregation :

Aggregation level ≤ 5%

Storage :

anti-IL-6 In Vivo Antibody - Low Endotoxin (MP5-20F3) is stable when stored at 2-8°C. Do not freeze. For long term storage, aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Applications :

ELISA Capture, ELISPOT, Neutralization, Functional Assays

Application Notes :

ELISA Sandwich: This antibody is useful as the capture antibody in a sandwich ELISA. A suitable detection antibody is at a concentration of approximately 0.5-2 ug/mL µg/ml. Each investigator should determine their own optimal working dilution for specific applications.

Isotype Control :

Rat IgG1 Isotype Control for In Vivo - Low Endotoxin [GL113] (ICH2246)

Use :

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Pricing Note :

Contact for industrial pricing

more info or order :

ichorbio product webpage