Anti-IL-10 In Vivo Antibody - Low Endotoxin (JES5-2A5) [ICH1118] ichorbio

product summary

company name :

ichorbio

product type :

antibody

product name :

Anti-IL-10 In Vivo Antibody - Low Endotoxin (JES5-2A5) [ICH1118] ichorbio

catalog :

ICH1118

quantity :

0.5 mg

price :

160 GBP

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

JES5-2A5

reactivity :

mouse

application :

western blot

more info or order :

ichorbio product webpage

product information

Product Type :

Low Endotoxin

ichorbio Cat Number :

ICH1118

Page Title :

Anti-IL-10 In Vivo Antibody - Low Endotoxin (JES5-2A5) [ICH1118] ichorbio

Page Heading :

Anti-IL-10 In Vivo Antibody - Low Endotoxin (JES5-2A5) [ICH1118]

Page Heading :

Bulk anti-IL-10 In Vivo Antibody - Low Endotoxin (JES5-2A5)

Product Benefits :

ichorbio's anti-IL-10 In Vivo Antibody - Low Endotoxin (JES5-2A5) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. ichorbio's low endotoxin antibodies have half the endotoxin of comparable antibodies from our competitors at less than 1.0 EU/mg. If ichorbio's low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin ( here for more information. ichorbio: the best antibodies for in vivo research.

Target :

IL-10

Clone :

JES5-2A5

Size1 :

0.5 mg

Academic Price1 :

160 GBP

Size2 :

1mg

Academic Price2 :

240

Isotype :

Rat IgG1

Other names :

Interleukin-10, IL-10, Cytokine synthesis inhibitory factor CSIF

UniProt :

P18893

Host :

Rat

Species Reactivity :

Mouse

Specificity :

Anti-IL-10 In Vivo Antibody - Low Endotoxin (JES5-2A5) recognizes an epitope on Mouse IL-10

Purification method :

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background :

Interleukin-10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is a homodimer protein produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines like IFN-gamma, IL-2, IL-3, TNFA and GM-CSF made by cells such as macrophages and the Type 1 T helper cells. IL-10 also displays potent abilities to suppress the antigen presentation capacity of antigen presenting cells. It is released by cytotoxic T-cells to inhibit the actions of NK cells during the immune response to viral infection. IL-10 plays a key role in peripheral T cell tolerance to allergens, autoantigens, transplantation antigens and tumor antigens. The JES5-2A5 antibody has been shown to neutralize the bioactivity of natural or recombinant IL-10

Immunogen :

Purified Recombinant Mouse IL-10

Concentration :

1.0 mg/ml

Formulation :

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.

Purity :

>95% by SDS-PAGE and HPLC

Endotoxin :

≤ 1.0 EU/mg as determined by the LAL method

Aggregation :

Aggregation level ≤ 5%

Storage :

anti-IL-10 In Vivo Antibody - Low Endotoxin (JES5-2A5) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Applications :

Western Blot

Application Notes :

Each investigator should determine their own optimal working dilution for specific applications.

Isotype Control :

Rat IgG1 Isotype Control for In Vivo - Low Endotoxin [GL113] (ICH2246)

Use :

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Pricing Note :

Contact for industrial pricing

more info or order :

ichorbio product webpage