Anti-RANKL In Vivo Antibody - Low Endotoxin (IK22/5) [ICH1114] ichorbio

product summary

company name :

ichorbio

product type :

antibody

product name :

Anti-RANKL In Vivo Antibody - Low Endotoxin (IK22/5) [ICH1114] ichorbio

catalog :

ICH1114

quantity :

0.5 mg

price :

160 GBP

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

IK22/5

reactivity :

mouse

application :

western blot, neutralization, immunoprecipitation, flow cytometry

more info or order :

ichorbio product webpage

product information

Product Type :

Low Endotoxin

ichorbio Cat Number :

ICH1114

Page Title :

Anti-RANKL In Vivo Antibody - Low Endotoxin (IK22/5) [ICH1114] ichorbio

Page Heading :

Anti-RANKL In Vivo Antibody - Low Endotoxin (IK22/5) [ICH1114]

Page Heading :

Bulk anti-RANKL In Vivo Antibody - Low Endotoxin (IK22/5)

Product Benefits :

ichorbio's anti-RANKL In Vivo Antibody - Low Endotoxin (IK22/5) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. ichorbio's low endotoxin antibodies have half the endotoxin of comparable antibodies from our competitors at less than 1.0 EU/mg. If ichorbio's low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin ( here for more information. ichorbio: the best antibodies for in vivo research.

Target :

RANKL

Clone :

IK22/5

Size1 :

0.5 mg

Academic Price1 :

160 GBP

Isotype :

Rat IgG2a

Other names :

Tumor necrosis factor ligand superfamily member 11, Tnfsf11, Osteoclast differentiation factor, ODF, Osteoprotegerin ligand, OPGL, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, TRANCE, CD254

UniProt :

O35235

Host :

Rat

Species Reactivity :

Mouse

Specificity :

Anti-RANKL In Vivo Antibody - Low Endotoxin (IK22/5) recognizes an epitope on Mouse RANKL

Purification method :

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background :

RANKL (Receptor Activator for Nuclear Factor κ B Ligand), also known as TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and ODF (osteoclast differentiation factor), is a member of the tumor necrosis factor family cytokine. RANKL is essential for osteoclast formation, activation, and survival. RANKL through interaction with its receptor RANK can modulate matrix degradation and inflammation. RANKL and RANK have essential roles in lymph node formation, establishment of the thymic microenvironment, and development of a lactating mammary gland during pregnancy. Consequently, novel drugs specifically targeting RANK, RANKL, and their signaling pathways in osteoclasts are expected to revolutionize the treatment of various ailments associated with bone loss, such as arthritis, periodontal disease, cancer metastases, and osteoporosis.

Immunogen :

Purified Recombinant Mouse RANKL (NSO-derived)

Concentration :

1.0 mg/ml

Formulation :

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.

Purity :

>95% by SDS-PAGE and HPLC

Endotoxin :

<0.5 EU/mg as determined by the LAL method

Aggregation :

Aggregation level ≤ 5%

Storage :

anti-RANKL In Vivo Antibody - Low Endotoxin (IK22/5) is stable when stored at 2-8°C. Do not freeze.This antibody is

Applications :

Flow Cytometry, Immunoprecipitation, Western Blot, Blocking

Application Notes :

Each investigator should determine their own optimal working dilution for specific applications.

Isotype Control :

Rat IgG2a In Vivo Isotype Control - Low Endotoxin [1-1] (ICH2244)

Use :

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Pricing Note :

Contact for industrial pricing

more info or order :

ichorbio product webpage