antibody

Anti-IL-12 In Vivo Antibody - Low Endotoxin (C17.8) [ICH1103] ichorbio

ICH1103

0.5 mg

160 GBP

monoclonal

rat

nonconjugated

C17.8

western blot, immunoprecipitation

ICH1103

Anti-IL-12 In Vivo Antibody - Low Endotoxin (C17.8) [ICH1103] ichorbio

Anti-IL-12 In Vivo Antibody - Low Endotoxin (C17.8) [ICH1103]

Bulk anti-IL-12 In Vivo Antibody - Low Endotoxin (C17.8)

ichorbio's anti-IL-12 In Vivo Antibody - Low Endotoxin (C17.8) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. ichorbio's low endotoxin antibodies have half the endotoxin of comparable antibodies from our competitors at less than 1.0 EU/mg. If ichorbio's low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin ( here for more information. ichorbio: the best antibodies for in vivo research.

IL-12

C17.8

0.5 mg

160 GBP

1mg

240

Rat IgG2a

NKSF, TSF, Maturation Factor, Cytotoxic Lymphocyte Maturation Factor (CLMF), p35

Rat

Mouse

Anti-IL-12 In Vivo Antibody - Low Endotoxin (C17.8) recognizes an epitope on Mouse IL-12

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Interleukin 12 (IL-12, NK cell stimulatory factor, cytotoxic lymphocyte maturation factor) is a heterodimeric cytokine that is naturally produced by dendritic cells , macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th1 cells, which is important in resistance against pathogens. It is known as a T cell stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-γ and TNF-A from T and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-γ. IL-12 also has anti-angiogenic activity, which can block the formation of new blood vessels. IL-12 binds to the IL-12 receptor and upon binding, IL-12R-β2 becomes tyrosine phosphorylated and provides binding sites for kinases, Tyk2 and Jak2. These are important in activating critical transcription factor proteins such as STAT4 which are implicated in IL-12 signaling in T cells and NK cells. IL-12 contributes to the antimycobacterial immune response by enhancing production of interferon-gamma, facilitating development of Th1 cells and augmenting cytotoxicity of antigen-specific T cells and natural killer cells.

Purified CHO expressed Recombinant Mouse IL-12 p70

1.0 mg/ml

0.01 M phosphate buffered saline (PBS) pH 7.0, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.

>95% by SDS-PAGE and HPLC

≤ 1.0 EU/mg as determined by the LAL method

Aggregation level ≤ 5%

anti-IL-12 In Vivo Antibody - Low Endotoxin (C17.8) is stable when stored at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Immunoprecipitation, Western Blot

Each investigator should determine their own optimal working dilution for specific applications.

Rat IgG2a In Vivo Isotype Control - Low Endotoxin [1-1] (ICH2244)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Contact for industrial pricing