Anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) [ICH1085] ichorbio

product summary

company name :

ichorbio

product type :

antibody

product name :

Anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) [ICH1085] ichorbio

catalog :

ICH1085

quantity :

1 mg

price :

80 GBP

clonality :

monoclonal

host :

hamsters

conjugate :

nonconjugated

clone name :

UC10-4F10-11

reactivity :

mouse

application :

western blot, flow cytometry

more info or order :

ichorbio product webpage

product information

Product Type :

Low Endotoxin

ichorbio Cat Number :

ICH1085

Page Title :

Anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) [ICH1085] ichorbio

Page Heading :

Anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) [ICH1085]

Page Heading :

Bulk anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11)

Product Benefits :

ichorbio's anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. ichorbio's low endotoxin antibodies have half the endotoxin of comparable antibodies from our competitors at less than 1.0 EU/mg. If ichorbio's low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin ( here for more information. ichorbio: the best antibodies for in vivo research.

Target :

CTLA-4

Clone :

UC10-4F10-11

Size1 :

1 mg

Academic Price1 :

80 GBP

Size2 :

5mg

Academic Price2 :

240

Size3 :

25mg

Academic Price3 :

640

Size4 :

50mg

Academic Price4 :

1040

Size5 :

100mg

Academic Price5 :

1600

Isotype :

Armenian Hamster IgG1

Other names :

Ctla4, Cytotoxic T-lymphocyte protein 4, CD152

UniProt :

P09793

Host :

Armenian Hamster

Species Reactivity :

Mouse

Specificity :

Anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) recognizes an epitope on Mouse CD152

Purification method :

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Antigen Distribution :

The UC10-4F10-11 antibody reacts with CD152 (CTLA-4), which is expressed on activated T lymphocytes 2-3 days after stimulation through T cell receptor.

Background :

CD152, also known as CTLA-4 or Ly-56 has significant similarity to CD28 in amino acid sequence, structure, and genomic organization. Furthermore, CD152 and CD28 share common B7 family counter-receptors. Unlike CD28, CD152 expression appears to be restricted to activated T cells and CD25+CD4+ regulatory T (Treg) cells. CD152 is thought to play a role in the induction and maintenance of immunological tolerance as well as the development of protective immunity and thymocyte regulation.

Immunogen :

Purified Recombinant Mouse CTLA4 Fc Fusion Protein

Concentration :

≥ 2.0 mg/ml

Formulation :

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.

Purity :

>95% by SDS-PAGE and HPLC

Endotoxin :

≤ 1.0 EU/mg as determined by the LAL method

Aggregation :

Aggregation level ≤ 5%

Storage :

anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) is stable when stored at 2-8°C. Do not freeze.

Applications :

Flow Cytometry, Western Blot, Functional Assays

Application Notes :

Functional Assay: Clone UC10-4F10-11 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding. Each investigator should determine their own optimal working dilution for specific applications.

Isotype Control :

Armenian Hamster IgG Isotype Control for In Vivo - Low Endotoxin [PIP] (ICH2251)

Antibodies against the same target :

Anti-CTLA-4 In Vivo Antibody - Low Endotoxin [9H10] (ICH1084) , Anti-CTLA-4 In Vivo Antibody - Ultra Low Endotoxin [9D9] (ICH1096UL) , Anti-CTLA-4 In Vivo Antibody - Low Endotoxin [9D9] (ICH1096) , Anti-CTLA-4 In Vivo Antibody - Ultra Low Endotoxin [9H10] (ICH1084UL)

Use :

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Pricing Note :

Contact for industrial pricing

more info or order :

ichorbio product webpage