antibody

Anti-CD278 In Vivo Antibody - Low Endotoxin (7E.17G9) [ICH1082] ichorbio

ICH1082

1 mg

80 GBP

monoclonal

rat

nonconjugated

7E.17G9

western blot, neutralization

ICH1082

Anti-CD278 In Vivo Antibody - Low Endotoxin (7E.17G9) [ICH1082] ichorbio

Anti-CD278 In Vivo Antibody - Low Endotoxin (7E.17G9) [ICH1082]

Bulk anti-CD278 In Vivo Antibody - Low Endotoxin (7E.17G9)

ichorbio's anti-CD278 In Vivo Antibody - Low Endotoxin (7E.17G9) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. ichorbio's low endotoxin antibodies have half the endotoxin of comparable antibodies from our competitors at less than 1.0 EU/mg. If ichorbio's low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin ( here for more information. ichorbio: the best antibodies for in vivo research.

CD278

7E.17G9

1 mg

80 GBP

5mg

240

25mg

640

50mg

1040

100mg

1600

Rat IgG2b

Inducible T-cell costimulator, Icos, Activation-inducible lymphocyte immunomediatory molecule, CD28 and CTLA-4-like protein, CCLP, CD28-related protein 1, CRP-1, Ailim

Q9WVS0

Rat

Mouse

Anti-CD278 In Vivo Antibody - Low Endotoxin (7E.17G9) recognizes an epitope on Mouse ICOS

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Inducible co-stimulator (ICOS), also called ALIM and H4, is a homodimeric protein and member of the CD28 family of immune co-stimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS enhances all basic T cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. Unlike the constitutively expressed CD28, ICOS has to be de novo induced on the T cell surface, does not up-regulate the production of IL-2, but superinduces the synthesis of IL-10, a B cell-differentiation factor. In vivo, ICOS is highly expressed on tonsillar T cells, which are closely associated with B cells in the apical light zone of germinal centres, the site of terminal B cell maturation. ICOS regulates CD28-dependent and CD28-independent CD4 (+) subset (Th1 and Th2) responses. It is a major regulator of the adaptive immune system and therefore, has a protective role in inflammatory autoimmune diseases.

1.0 - 5.0 mg/ml

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.

>95% by SDS-PAGE and HPLC

≤ 1.0 EU/mg as determined by the LAL method

Aggregation level ≤ 5%

anti-CD278 In Vivo Antibody - Low Endotoxin (7E.17G9) is stable when stored at 2-8°C. Do not freeze. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Western Blot, Blocking, Functional Assays

Each investigator should determine their own optimal working dilution for specific applications.

Rat IgG2b In Vivo Isotype Control - Low Endotoxin [1-2] (ICH2243)

Anti-CD278 In Vivo Antibody - Ultra Low Endotoxin [7E.17G9] (ICH1082UL)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Contact for industrial pricing