Anti-CD119 In Vivo Antibody - Ultra Low Endotoxin (GIR 208) [ICH1028UL] ichorbio

product summary

company name :

ichorbio

product type :

antibody

product name :

Anti-CD119 In Vivo Antibody - Ultra Low Endotoxin (GIR 208) [ICH1028UL] ichorbio

catalog :

ICH1028UL

quantity :

5 mg

price :

312 GBP

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

GIR 208

reactivity :

human

application :

western blot, neutralization, immunoprecipitation

more info or order :

ichorbio product webpage

product information

Product Type :

Ultra Low Endotoxin

ichorbio Cat Number :

ICH1028UL

Page Title :

Anti-CD119 In Vivo Antibody - Ultra Low Endotoxin (GIR 208) [ICH1028UL] ichorbio

Page Heading :

Anti-CD119 In Vivo Antibody - Ultra Low Endotoxin (GIR 208) [ICH1028UL]

Page Heading :

Bulk anti-CD119 In Vivo Antibody - Ultra Low Endotoxin (GIR 208)

Product Benefits :

ichorbio's anti-CD119 In Vivo Antibody - Ultra Low Endotoxin (GIR 208) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. This means that ichorbio's ultra low-endoxin antibodies have the lowest endotoxin in the industry at less than 0.75 EU/mg. The purity of ichorbio's ultra low endotoxin antibodies are unsurpassed at >98% and they are all pathogen tested and third-party certified by IDEXX BioReseach of meet the lowest mycoplasma specification and free of any viral pathogens of concern. ichorbio offers Amazon vouchers or donations to the NC3Rs for reviews of this product: click here for more information. ichorbio: the best antibodies for in vivo research.

Target :

CD119

Clone :

GIR 208

Size1 :

5 mg

Academic Price1 :

312 GBP

Size2 :

25mg

Academic Price2 :

832

Size3 :

50mg

Academic Price3 :

1352

Size4 :

100mg

Academic Price4 :

2080

Isotype :

Mouse IgG1

Other names :

Interferon gamma receptor 1, IFN-gamma receptor 1, IFN-gamma-R1, CDw119, Interferon gamma receptor alpha-chain2, IFN-gamma-R-alpha

UniProt :

P15260

Host :

Mouse

Species Reactivity :

Human

Specificity :

Anti-CD119 In Vivo Antibody - Ultra Low Endotoxin (GIR 208) recognizes Human IFN gamma R alpha

Purification method :

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Antigen Distribution :

The IFN-gamma receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes.

Background :

Interferon-gamma (IFN-gamma) exerts its biologic effects by interacting with a single high affinity receptor, IFN-gamma receptor. This receptor is present on almost all cell types except mature erythrocytes. The IFN-gamma receptor consists of two polypeptide chains alpha and beta and requires association of JAK1, JAK2 and Stat1 for IFN-gamma signal transduction. In signal transduction, IFN-gamma induces tyrosine phosphorylation of IFN-gamma receptor alpha (IFNGR1) leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-gamma induced gene transcription. The IFN-gamma receptor is structurally related to the recently cloned IL-10 receptor. GIR 208 binds IFNGR1 and blocks binding of IFN-gamma to the receptor.

Immunogen :

Human IFN-gamma R alpha, Purified from human placenta

Concentration :

1.0 - 5.0 mg/ml

Formulation :

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.

Purity :

>98% by SDS-PAGE and HPLC

Endotoxin :

≤ 0.75 EU/mg as determined by the LAL method

Aggregation :

Aggregation level ≤ 1%

IMPACT Pathogen Test :

We use the IMPACT test generated by IDEXX Laboratories to guarantee our Ultra Low Endotoxin antibodies are pathogen free. Our mouse antibodies are tested for: Mycoplasma spp. Mycoplasma pulmonis Sendai virus Mouse hepatitis virus Pneumonia virus of mice Minute virus of mice Mouse parvovirus (MPV1-5) Theiler's murine encephalomyelitis virus Murine norovirus Reovirus 3 Mouse rotavirus Ectromelia virus Lymphocytic choriomeningitis virus Polyoma virus Lactate dehydrogenase-elevating virus Mouse adenovirus (MAD1, MAD2) Mouse cytomegalovirus K virus Mouse thymic virus Hantaan virus Corynebacterium bovis Corynebacterium spp. (HAC2)

Storage :

anti-CD119 In Vivo Antibody - Ultra Low Endotoxin (GIR 208) is stable when stored at 2-8°C. For long term storage we recommended to store at -80°C.

Applications :

Immunoprecipitation, Western Blot, Blocking, Functional Assays

Application Notes :

Functional Assay: Clone GIR-208 can be used as an isotype with Clone MAR1-5A3 (Anti-Mouse IFNAR1) Each investigator should determine their own optimal working dilution for specific applications.

Isotype Control :

Mouse IgG1 Isotype Control for In Vivo - Ultra Low Endotoxin [HKSP] (ICH2247UL)

Related Antibody :

Anti-CD119 In Vivo Antibody - Low Endotoxin [GIR 208] (ICH1028)

Use :

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Pricing Note :

Contact for industrial pricing

more info or order :

ichorbio product webpage