Anti-CD119 In Vivo Antibody - Low Endotoxin (GIR 208) [ICH1028] ichorbio

product summary

company name :

ichorbio

product type :

antibody

product name :

Anti-CD119 In Vivo Antibody - Low Endotoxin (GIR 208) [ICH1028] ichorbio

catalog :

ICH1028

quantity :

1 mg

price :

80 GBP

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

GIR 208

reactivity :

human

application :

western blot, immunoprecipitation

more info or order :

ichorbio product webpage

product information

Product Type :

Low Endotoxin

ichorbio Cat Number :

ICH1028

Page Title :

Anti-CD119 In Vivo Antibody - Low Endotoxin (GIR 208) [ICH1028] ichorbio

Page Heading :

Anti-CD119 In Vivo Antibody - Low Endotoxin (GIR 208) [ICH1028]

Page Heading :

Bulk anti-CD119 In Vivo Antibody - Low Endotoxin (GIR 208)

Product Benefits :

ichorbio's anti-CD119 In Vivo Antibody - Low Endotoxin (GIR 208) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. ichorbio's low endotoxin antibodies have half the endotoxin of comparable antibodies from our competitors at less than 1.0 EU/mg. If ichorbio's low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin ( here for more information. ichorbio: the best antibodies for in vivo research.

Target :

CD119

Clone :

GIR 208

Size1 :

1 mg

Academic Price1 :

80 GBP

Size2 :

5mg

Academic Price2 :

240

Size3 :

25mg

Academic Price3 :

640

Size4 :

50mg

Academic Price4 :

1040

Size5 :

100mg

Academic Price5 :

1600

Isotype :

Mouse IgG1

Other names :

Interferon gamma receptor 1, IFN-gamma receptor 1, IFN-gamma-R1, CDw119, Interferon gamma receptor alpha-chain2, IFN-gamma-R-alpha

UniProt :

P15260

Host :

Mouse

Species Reactivity :

Human

Specificity :

Anti-CD119 In Vivo Antibody - Low Endotoxin (GIR 208) recognizes Human IFN gamma R alpha

Purification method :

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Antigen Distribution :

The IFN-gamma receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes.

Background :

Interferon-gamma (IFN-gamma) exerts its biologic effects by interacting with a single high affinity receptor, IFN-gamma receptor. This receptor is present on almost all cell types except mature erythrocytes. The IFN-gamma receptor consists of two polypeptide chains alpha and beta and requires association of JAK1, JAK2 and Stat1 for IFN-gamma signal transduction. In signal transduction, IFN-gamma induces tyrosine phosphorylation of IFN-gamma receptor alpha (IFNGR1) leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-gamma induced gene transcription. The IFN-gamma receptor is structurally related to the recently cloned IL-10 receptor. GIR 208 binds IFNGR1 and blocks binding of IFN-gamma to the receptor.

Immunogen :

Human IFN-gamma R alpha, Purified from human placenta

Concentration :

1.0 - 5.0 mg/ml

Formulation :

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.

Purity :

>95% by SDS-PAGE and HPLC

Endotoxin :

≤ 1.0 EU/mg as determined by the LAL method

Aggregation :

Aggregation level ≤ 5%

Storage :

anti-CD119 In Vivo Antibody - Low Endotoxin (GIR 208) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Applications :

Immunoprecipitation, Western Blot

Application Notes :

Each investigator should determine their own optimal working dilution for specific applications.

Isotype Control :

Mouse IgG1 Isotype Control for In Vivo - Low Endotoxin [HKSP] (ICH2247)

Related Antibody :

Anti-CD119 In Vivo Antibody - Ultra Low Endotoxin [GIR 208] (ICH1028UL)

Use :

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Pricing Note :

Contact for industrial pricing

more info or order :

ichorbio product webpage