Anti-EGFR In Vivo Antibody - Ultra Low Endotoxin (EGFR.1) [ICH1021UL] ichorbio

product summary

company name :

ichorbio

product type :

antibody

product name :

Anti-EGFR In Vivo Antibody - Ultra Low Endotoxin (EGFR.1) [ICH1021UL] ichorbio

catalog :

ICH1021UL

quantity :

5 mg

price :

312 GBP

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

EGFR.1

reactivity :

human

application :

western blot

more info or order :

ichorbio product webpage

product information

Product Type :

Ultra Low Endotoxin

ichorbio Cat Number :

ICH1021UL

Page Title :

Anti-EGFR In Vivo Antibody - Ultra Low Endotoxin (EGFR.1) [ICH1021UL] ichorbio

Page Heading :

Anti-EGFR In Vivo Antibody - Ultra Low Endotoxin (EGFR.1) [ICH1021UL]

Page Heading :

Bulk anti-EGFR In Vivo Antibody - Ultra Low Endotoxin (EGFR.1)

Product Benefits :

ichorbio's anti-EGFR In Vivo Antibody - Ultra Low Endotoxin (EGFR.1) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. This means that ichorbio's ultra low-endoxin antibodies have the lowest endotoxin in the industry at less than 0.75 EU/mg. The purity of ichorbio's ultra low endotoxin antibodies are unsurpassed at >98% and they are all pathogen tested and third-party certified by IDEXX BioReseach of meet the lowest mycoplasma specification and free of any viral pathogens of concern. ichorbio offers Amazon vouchers or donations to the NC3Rs for reviews of this product: click here for more information. ichorbio: the best antibodies for in vivo research.

Target :

EGFR

Clone :

EGFR.1

Size1 :

5 mg

Academic Price1 :

312 GBP

Size2 :

25mg

Academic Price2 :

832

Size3 :

50mg

Academic Price3 :

1352

Size4 :

100mg

Academic Price4 :

2080

Isotype :

Mouse IgG2b

Other names :

Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, ERBB, ERBB1, HER1

UniProt :

P00533

Host :

Mouse

Species Reactivity :

Human

Specificity :

Anti-EGFR In Vivo Antibody - Ultra Low Endotoxin (EGFR.1) recognizes an epitope on Human EGFR

Purification method :

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background :

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. EGFR (epidermal growth factor receptor) exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor A (TGFA) (note, a full list of the ligands able to activate EGFR and other members of the ErbB family is given in the ErbB article). ErbB2 has no known direct activating ligand, and may be in an activated state constitutively or become active upon heterodimerization with other family members such as EGFR. Upon activation by its growth factor ligands, EGFR undergoes a transition from an inactive monomeric form to an active homodimer - although there is some evidence that preformed inactive dimers may also exist before ligand binding. In addition to forming homodimers after ligand binding, EGFR may pair with another member of the ErbB receptor family, such as ErbB2/Her2/neu, to create an activated heterodimer. There is also evidence to suggest that clusters of activated EGFRs form, although it remains unclear whether this clustering is important for activation itself or occurs subsequent to activation of individual dimers.

Immunogen :

A431 cultured cells

Concentration :

1.0 - 5.0 mg/ml

Formulation :

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.

Purity :

>98% by SDS-PAGE and HPLC

Endotoxin :

≤ 0.75 EU/mg as determined by the LAL method

Aggregation :

Aggregation level ≤ 1%

IMPACT Pathogen Test :

We use the IMPACT test generated by IDEXX Laboratories to guarantee our Ultra Low Endotoxin antibodies are pathogen free. Our mouse antibodies are tested for: Mycoplasma spp. Mycoplasma pulmonis Sendai virus Mouse hepatitis virus Pneumonia virus of mice Minute virus of mice Mouse parvovirus (MPV1-5) Theiler's murine encephalomyelitis virus Murine norovirus Reovirus 3 Mouse rotavirus Ectromelia virus Lymphocytic choriomeningitis virus Polyoma virus Lactate dehydrogenase-elevating virus Mouse adenovirus (MAD1, MAD2) Mouse cytomegalovirus K virus Mouse thymic virus Hantaan virus Corynebacterium bovis Corynebacterium spp. (HAC2)

Storage :

anti-EGFR In Vivo Antibody - Ultra Low Endotoxin (EGFR.1) is stable when stored at 2-8°C. Do not freeze.

Applications :

Western Blot

Application Notes :

Each investigator should determine their own optimal working dilution for specific applications.

Isotype Control :

Mouse IgG2b Isotype Control for In Vivo - Ultra Low Endotoxin [MPC-11] (ICH2250UL)

Related Antibody :

Anti-EGFR In Vivo Antibody - Low Endotoxin [EGFR.1] (ICH1021)

Use :

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Pricing Note :

Contact for industrial pricing

more info or order :

ichorbio product webpage