antibody

Anti-CD20 In Vivo Antibody - Ultra Low Endotoxin (2H7) [ICH1012UL] ichorbio

ICH1012UL

5 mg

312 GBP

monoclonal

mouse

nonconjugated

2H7

ICH1012UL

Anti-CD20 In Vivo Antibody - Ultra Low Endotoxin (2H7) [ICH1012UL] ichorbio

Anti-CD20 In Vivo Antibody - Ultra Low Endotoxin (2H7) [ICH1012UL]

Bulk anti-CD20 In Vivo Antibody - Ultra Low Endotoxin (2H7)

ichorbio's anti-CD20 In Vivo Antibody - Ultra Low Endotoxin (2H7) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. This means that ichorbio's ultra low-endoxin antibodies have the lowest endotoxin in the industry at less than 0.75 EU/mg. The purity of ichorbio's ultra low endotoxin antibodies are unsurpassed at >98% and they are all pathogen tested and third-party certified by IDEXX BioReseach of meet the lowest mycoplasma specification and free of any viral pathogens of concern. ichorbio offers Amazon vouchers or donations to the NC3Rs for reviews of this product: click here for more information. ichorbio: the best antibodies for in vivo research.

CD20

2H7

5 mg

312 GBP

25mg

832

50mg

1352

100mg

2080

Mouse IgG2b

B-lymphocyte surface antigen B1, Bp35, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1, MS4A1

P11836

Mouse

Human

Anti-CD20 In Vivo Antibody - Ultra Low Endotoxin (2H7) recognizes an epitope on Human CD20

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

The CD20 antigen, also called MS4A1, B1 and Bp35, is a non-glycosylated, transmembrane spanning, phosphoprotein. The CD20 protein is present on human pre B lymphocytes and on B lymphocytes at all stages of maturation, except on plasma cells, and is synchronous with the expression of surface IgM. It is also expressed in some follicular dendritic cells and at low levels on a T cell subset. CD20 has been shown to be heavily phosphorylated in activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn), and exists in a complex with MHC class I and II, CD53, CD81, and CD82. Extensive CD20 cross-linking may also influence cell death by apoptosis. Therapy with antibodies against CD20 is a widely used regimen in the treatment of all B cell lymphomas and leukemias.

1.0 - 5.0 mg/ml

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.

>98% by SDS-PAGE and HPLC

≤ 0.75 EU/mg as determined by the LAL method

Aggregation level ≤ 1%

We use the IMPACT test generated by IDEXX Laboratories to guarantee our Ultra Low Endotoxin antibodies are pathogen free. Our mouse antibodies are tested for: Mycoplasma spp. Mycoplasma pulmonis Sendai virus Mouse hepatitis virus Pneumonia virus of mice Minute virus of mice Mouse parvovirus (MPV1-5) Theiler's murine encephalomyelitis virus Murine norovirus Reovirus 3 Mouse rotavirus Ectromelia virus Lymphocytic choriomeningitis virus Polyoma virus Lactate dehydrogenase-elevating virus Mouse adenovirus (MAD1, MAD2) Mouse cytomegalovirus K virus Mouse thymic virus Hantaan virus Corynebacterium bovis Corynebacterium spp. (HAC2)

anti-CD20 In Vivo Antibody - Ultra Low Endotoxin (2H7) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Western Blot, Functional Assays

Each investigator should determine their own optimal working dilution for specific applications.

Mouse IgG2b Isotype Control for In Vivo - Ultra Low Endotoxin [MPC-11] (ICH2250UL)

Anti-CD20 In Vivo Antibody - Low Endotoxin [2H7] (ICH1012)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

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