Anti-CD8 In Vivo Antibody - Low Endotoxin (UCHT-4) [ICH1005] ichorbio

product summary

company name :

ichorbio

product type :

antibody

product name :

Anti-CD8 In Vivo Antibody - Low Endotoxin (UCHT-4) [ICH1005] ichorbio

catalog :

ICH1005

quantity :

1 mg

price :

80 GBP

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

UCHT-4

application :

western blot, flow cytometry

more info or order :

ichorbio product webpage

product information

Product Type :

Low Endotoxin

ichorbio Cat Number :

ICH1005

Page Title :

Anti-CD8 In Vivo Antibody - Low Endotoxin (UCHT-4) [ICH1005] ichorbio

Page Heading :

Anti-CD8 In Vivo Antibody - Low Endotoxin (UCHT-4) [ICH1005]

Page Heading :

Bulk anti-CD8 In Vivo Antibody - Low Endotoxin (UCHT-4)

Product Benefits :

ichorbio's anti-CD8 In Vivo Antibody - Low Endotoxin (UCHT-4) is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. ichorbio's low endotoxin antibodies have half the endotoxin of comparable antibodies from our competitors at less than 1.0 EU/mg. If ichorbio's low endotoxin antibodies are not low enough we also offer ultra low endotoxin antibodies which have even less endotoxin ( here for more information. ichorbio: the best antibodies for in vivo research.

Target :

CD8

Clone :

UCHT-4

Size1 :

1 mg

Academic Price1 :

80 GBP

Size2 :

5mg

Academic Price2 :

240

Size3 :

25mg

Academic Price3 :

640

Size4 :

50mg

Academic Price4 :

1040

Size5 :

100mg

Academic Price5 :

1600

Isotype :

Mouse IgG2a

Host :

Mouse

Species Reactivity :

Human

Specificity :

Anti-CD8 In Vivo Antibody - Low Endotoxin (UCHT-4) recognizes Human CD8. Anti-Human CD8 recognizes a T-cell glycoprotein cell surface complex (Mr 32 kDa) which defines the cytotoxic/suppressor population of mature T-lymphocytes. The CD8 complex interacts with class I MHC molecules resulting in increased adhesion between CD8+ T-lymphocytes and their target cells. Binding of the CD8 antigen to Class I MHC molecules enhances T-cell activation. The cytoplasmic portion of the CD8 antigen is associated with a protein tyrosine kinase (p56lck).

Purification method :

This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Antigen Distribution :

The CD8 antigen is expressed on approximately 19-48% of normal human peripheral blood lymphocytes and > 90% of normal thymocytes. It is also present on a subset of NK cells. Subjects infected with HIV have been shown to exhibit increased levels of CD8+ lymphocytes with a continual decrease in CD4+ lymphocytes.

Background :

Anti-CD8 may be used in studies of immunoregulation and T-lymphocyte mediated suppression, autoimmune disorders, immunodeficiency states and acute lymphoblastic leukemia and lymphoma.

Concentration :

1.0 - 5.0 mg/ml

Formulation :

0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.

Purity :

>95% by SDS-PAGE and HPLC

Endotoxin :

<1.0 EU/mg as determined by the LAL method

Aggregation :

Aggregation level ≤ 5%

Storage :

anti-CD8 In Vivo Antibody - Low Endotoxin (UCHT-4) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.

Applications :

Flow Cytometry, Western Blot

Application Notes :

Each investigator should determine their own optimal working dilution for specific applications.

Isotype Control :

Mouse IgG2a In Vivo Isotype Control - Low Endotoxin [C1.18.4] (ICH2245)

Antibodies against the same target :

Anti-CD8 In Vivo Antibody - Low Endotoxin [YTS-169] (ICH1043) , Anti-CD8 In Vivo Antibody - Ultra Low Endotoxin [YTS-169] (ICH1043UL)

Use :

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Pricing Note :

Contact for industrial pricing

more info or order :

ichorbio product webpage