Anti-CEP290 [1F3G10] NEW | Ximbio 153781 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-CEP290 [1F3G10] NEW

catalog :

153781

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

80184

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-CEP290 [1F3G10] NEW

Catalogue Number :

153781

Applications :

IHC IF WB

Antigen/Gene or Protein Targets :

CEP290, UniProt ID:O15078

Synonyms :

Centrosomal protein of 290 kDa, Cep290, Bardet-Biedl syndrome 14 protein, Cancer/testis antigen 87, CT87, Nephrocystin-6, Tumor antigen se2-2

Reactivity :

Human

Relevance :

CEP290 is involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (PubMed:18694559). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (PubMed:24421332). Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes (By similarity). Required for efficient recruitment of RAB8A to primary cilium (PubMed:17705300). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2, BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating IQCB1/NPHP5 (PubMed:25552655). Activates ATF4-mediated transcription (PubMed:16682973).

Host :

Mouse

Immunogen :

Recombinant human CEP290 amino acids 1-299 (bacterially expressed from pGEX4T as a GST fusion, then thrombin-cleaved and purified).

Subclass :

IgG2a

Positive Control :

IF and WB: hTERT-RPE1 cells

Molecular Weight (kDa) :

290

Myeloma Used :

Sp2/0-Ag14

Research Area :

Cancer, Cell Cycle, Metabolism

Notes :

Staining pattern: Centriole end

more info or order :

Ximbio product webpage