Anti-EGFR [225] | Ximbio 153506 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-EGFR [225]

catalog :

153506

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1950

reactivity :

human

more info or order :

Ximbio product webpage

product information

Name :

Anti-EGFR [225]

Catalogue Number :

153506

Antigen/Gene or Protein Targets :

Epidermal Growth Factor Receptor

Synonyms :

EGFR, ErbB-1, HER1

Reactivity :

Human

Relevance :

Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including squamous-cell carcinoma of the lung, anal cancers, glioblastoma and epithelial tumors of the head and neck. These somatic mutations involving EGFR lead to its constant activation, which produces uncontrolled cell division. In glioblastoma a more or less specific mutation of EGFR, called EGFRvIII is often observed. Mutations, amplifications or misregulations of EGFR or family members are implicated in about 30% of all epithelial cancers. Monoclonal 225 is a classic reagent in tumor therapy with more than 100 published references. The human/mouse chimeric antibody known as Cetuximab was derived from this monoclonal antibody.

Host :

Mouse

Subclass :

IgG1

Research Area :

Cancer

more info or order :

Ximbio product webpage