product summary
company name :
Ximbio
product type :
antibody
product name :
Anti-Lamin B receptor [BB3SS4B5]
catalog :
153491
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3930
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
Ximbio product webpage
product information
Name :
Anti-Lamin B receptor [BB3SS4B5]
Catalogue Number :
153491
Applications :
IHC IF WB
Antigen/Gene or Protein Targets :
Lamin B receptor
Synonyms :
DHCR 14B antibody, DHCR14B antibody, Integral nuclear envelope inner membrane protein antibody, Lamin-B receptor antibody, LBR antibody, LBR_HUMAN antibody, LMN 2R antibody, LMN2R antibody, MGC9041 antibody, PHA antibody, PRO0650 antibody
Reactivity :
Human and Mouse
Relevance :
Lamin B Receptor (LBR) is a polytopic inner nuclear membrane protein. Its nucleoplasmic domain interacts with components of the nuclear lamina as well as with chromatin, via HP1. LBR also exhibits C14 sterol reductase activity. Deficiency of LBR in humans results in Pelget-Huët anomaly featuring hypolobulated granulocyte nuclei. Homozygous loss of LBR causes Greenberg skeletal dysplasia a fetal lethal disorder associated with defective cholesterol metabolism.
Host :
Mouse
Immunogen :
GST fused to N-terminal fragment of human LBR (amino acids residues 1-211)
Subclass :
IgG1 kappa
Positive Control :
Hela, C2C12, NIE-115
Myeloma Used :
Sp2/0-Ag14
Strain :
C57BL/6
Research Area :
Cell Signaling & Signal Transduction
Notes :
Hybridoma cell line monoclonality was achieved by single cell sorting using flow cytometry. Human LBR is 70,7kDa and mouse is 71.4kDa. Entrez Gene Number is 3930. Gene symbol is LBR. UniProt Number is Q14739. Immunohistochemistry: paraffin-embedded section, cryosections. Immunocytochemistry/Immunofluorescence: formaldehyde, methanol fixation with methanol fixation resulting in a brighter signal.
more info or order :
Ximbio product webpage
company information
Ximbio
enquiries@ximbio.com
ximbio.com