Anti-Lamin A+C [LASS2D9] | Ximbio 153489 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Lamin A+C [LASS2D9]

catalog :

153489

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4000

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-Lamin A+C [LASS2D9]

Catalogue Number :

153489

Applications :

IHC IF WB

Antigen/Gene or Protein Targets :

Lamin A and Lamin C

Synonyms :

70 kDa lamin antibody, Cardiomyopathy dilated 1A (autosomal dominant) antibody, CDCD1 antibody, CDDC antibody, CMD1A antibody, CMT2B1 antibody, EMD2 antibody, FPL antibody, FPLD antibody, FPLD2 antibody, HGPS antibody, IDC antibody, Lamin A antibody, Lamin A/C antibody, Lamin A/C like 1 antibody, Lamin antibody, Lamin C antibody, Lamin-A/C antibody, LDP1 antibody,

Reactivity :

Human and Mouse

Relevance :

Lamins A and C are major components of the nuclear lamina, a thin protein meshwork located at the nuclear face of the nuclear envelope (NE). The lamina provides structural integrity to the NE and is involved in many other aspects of nuclear biology including transcription and chromatin organization. Lamins A and C arise from the LMNA gene by alternative splicing and majority of adult tissues express at least one of the isoform. The LMNA gene has been extensively studies due to its association with variety of human diseases. Mutations in LMNA have been linked 12 distinct disorders, including Emery-Dreifus muscular dystrophy, dilated cardiomyopathy, Dunnigan-type partial lipodystrophy and Hutchinson-Gilford progeria syndrome.

Host :

Mouse

Subclass :

IgG3 kappa

Positive Control :

Hela, 293T, C2C12, fibroblasts

Myeloma Used :

Sp2/0-Ag14

Strain :

C57BL/6

Research Area :

Cell Signaling & Signal Transduction

Notes :

Lamin A is 74kDa and Lamin C is 65 kDa. Entrez Gene Number is 4000. Gene symbol is LMNA. UniProt Number is P02545. Immunohistochemistry: paraffin-embedded section, cryosections. Immunocytochemistry/Immunofluorescence: formaldehyde, methanol fixation.

more info or order :

Ximbio product webpage