product summary
company name :
Ximbio
product type :
antibody
product name :
Anti-Nesprin-1 [9F10]
catalog :
153480
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
64009
reactivity :
mouse, rat
application :
western blot, immunocytochemistry
more info or order :
Ximbio product webpage
product information
Name :
Anti-Nesprin-1 [9F10]
Catalogue Number :
153480
Applications :
IF WB
Antigen/Gene or Protein Targets :
Nesprin-1
Synonyms :
Nesp1 antibody, Nesprin-1 antibody, Nuclear envelope spectrin repeat protein 1 antibody
Reactivity :
Mouse and Rat
Relevance :
A notable feature of metazoan cells is their morphological plasticity associated with acquisition of a range of complex activities. Implementation of numerous specialized functions during differentiation is dependent upon the rearrangement and transformation of organelles, including the cell nucleus. Crucial to many cell specific changes in nuclear localization and organization is establishment of connections between the nucleus and cytoskeleton. Such connections are formed in part by KASH-domain proteins of the outer nuclear membrane (ONM). In mammals six KASH proteins are known (Nesprins 1, 2, 3, 4, LRMP and KASH5). Appropriate localization of KASH proteins is dependent upon tethering in the ONM by SUN-domain proteins of the inner nuclear membrane. Together, SUN-KASH pairs form LINC complexes (LInker of the Nucleoskeleton and Cytoskeleton) that span both nuclear membranes and which couple nuclear structures to the cytoskeleton. In recent years it has become apparent that LINC complex defects may contribute to a number of human genetic diseases, including muscular dystrophy, cerebellar ataxia, hearing loss and infertility.
Host :
Mouse
Immunogen :
GST fused to residues 8,165-8,473 of mouse Nesp1
Subclass :
IgG2b kappa
Myeloma Used :
Sp2/0-Ag14
Strain :
C57BL/6
Research Area :
Developmental Biology, Gene Expression
more info or order :
Ximbio product webpage
company information
Ximbio
enquiries@ximbio.com
ximbio.com