Anti-Phospho-Rb (Ser608) [51B7] | Ximbio 153409 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Phospho-Rb (Ser608) [51B7]

catalog :

153409

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5925

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-Phospho-Rb (Ser608) [51B7]

Catalogue Number :

153409

Applications :

IHC IF WB

Antigen/Gene or Protein Targets :

Rb (phospho Ser608)

Synonyms :

Retinoblastoma 1; RB1; p105-Rb; RB; pp110; pRb; OSRC

Reactivity :

Human and Mouse

Relevance :

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia. Phosphorylation of Rb at S608 depends on CDK4.

Host :

Mouse

Immunogen :

Synthetic peptide C-ADMYLSPLRSPK phosphorylated at S608, conugated to KLH

Subclass :

IgG1

Molecular Weight (kDa) :

111

Research Area :

Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Immunology

more info or order :

Ximbio product webpage