Anti-Phospho-Raf1 (Ser338) [DPR/2/2A/3A] | Ximbio 153408 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Phospho-Raf1 (Ser338) [DPR/2/2A/3A]

catalog :

153408

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

5894

reactivity :

human

application :

western blot

more info or order :

Ximbio product webpage

product information

Name :

Anti-Phospho-Raf1 (Ser338) [DPR/2/2A/3A]

Catalogue Number :

153408

Applications :

Antigen/Gene or Protein Targets :

Raf-1

Synonyms :

RAF1; Raf-1; c-Raf; NS5; CRAF; v-raf-1 murine leukemia viral oncogene homolog 1

Reactivity :

Human

Relevance :

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

Host :

Rat

Immunogen :

Synthetic peptide GQRDpSSYpYWEIEAS coupled to glutaraldehyde

Subclass :

IgG1

Research Area :

Cancer, Immunology

more info or order :

Ximbio product webpage