Anti-p53 [DO-11] | Ximbio 153402 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-p53 [DO-11]

catalog :

153402

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7157

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation

more info or order :

Ximbio product webpage

product information

Name :

Anti-p53 [DO-11]

Catalogue Number :

153402

Applications :

IHC IP WB

Antigen/Gene or Protein Targets :

Human TP53 / p53

Synonyms :

p53

Reactivity :

Human

Relevance :

Mouse anti human p53 antibody, clone DO-11 recognizes the human cellular tumor antigen p53, also known as p53 tumour suppressor protein or NY-CO-13. p53 is a 393 amino acid ~53kDa cytoplasmic/ nuclear protein up-regulated in response to DNA damage and is found in a wide variety of transformed cells (UniProt: P04637). DO-11 binds to an epitope within the central region of p53 between amino acids 181 - 190 defining a cryptic epitope exposed in unfolded/ denatured p53. Nine isoforms of human p53 are produced by alternative splicing and promotor usage, the epitope recognized by clone DO-11 is present in all isoforms. Mouse anti Human p53 antibody, clone DO-11 recognizes mutant forms of p53 (Warnock et al. 2011) and has been used successfully for detection of p53 by western blotting (Wei et al. 2012).

Host :

Mouse

Immunogen :

Recombinant human p53

Subclass :

IgG1

Positive Control :

Colon or breast carcinoma tissue

Molecular Weight (kDa) :

Research Area :

Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Immunology

more info or order :

Ximbio product webpage