Anti-MCM2 [CRCT2.1] | Ximbio 153395 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-MCM2 [CRCT2.1]

catalog :

153395

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4171

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

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product information

Name :

Anti-MCM2 [CRCT2.1]

Catalogue Number :

153395

Applications :

IHC WB

Antigen/Gene or Protein Targets :

MCM2

Synonyms :

MCM 2; CCNL1; CDCL1

Reactivity :

Human

Relevance :

The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro. Cleavage of MCM3, which can be prevented by caspase inhibitors, results in the inactivation of the MCM complex (composed of at least MCM proteins 2-6) during apoptosis. A complex composed of MCM4, MCM6 and MCM7 has been shown to be involved in DNA helicase activity; and MCM5 is involved in IFN-?-induced Stat1 transcription activation.

Host :

Mouse

Immunogen :

Bacterially expressed human MCM2

Subclass :

IgG1

Positive Control :

HeLa nuclear extract lysate

Molecular Weight (kDa) :

130

Myeloma Used :

Sp2/0-Ag14

Research Area :

Epigenetics & Nuclear Signalling

more info or order :

Ximbio product webpage