Anti-Lewis Y [C14] | Ximbio 153394 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Lewis Y [C14]

catalog :

153394

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

C14

application :

ELISA, immunohistochemistry, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-Lewis Y [C14]

Catalogue Number :

153394

Applications :

ELISA FACS IHC

Antigen/Gene or Protein Targets :

Lewis Y

Reactivity :

Human

Relevance :

MAbs targeting both Lewis(y) and Lewis(b) may have a therapeutic advantage over mAbs targeting just one hapten. 692/29 has a more restricted normal tissue distribution and a higher antigen threshold for killing which should reduce its toxicity compared to a Lewis(y) specific mAb. 692/29 has an ability to directly kill tumours whereas the anti-Lewis(b) mAb does not. This suggests that Lewis(y) but not Lewis(b) are functional glycans. 692/29 showed good anti-tumour responses in vivo and is a strong therapeutic candidate.

Host :

Mouse

Immunogen :

Tumor cells

Subclass :

IgG

Strain :

Balb/c

Research Area :

Cancer, Epigenetics & Nuclear Signalling

more info or order :

Ximbio product webpage