Anti-Lewis Y [69/229] | Ximbio 153393 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Lewis Y [69/229]

catalog :

153393

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

69/229

reactivity :

human

application :

immunohistochemistry, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-Lewis Y [69/229]

Catalogue Number :

153393

Applications :

FACS IHC

Antigen/Gene or Protein Targets :

Lewis Y

Reactivity :

Human

Relevance :

MAbs targeting both Lewis(y) and Lewis(b) may have a therapeutic advantage over mAbs targeting just one hapten. 692/29 has a more restricted normal tissue distribution and a higher antigen threshold for killing which should reduce its toxicity compared to a Lewis(y) specific mAb. 692/29 has an ability to directly kill tumours whereas the anti-Lewis(b) mAb does not. This suggests that Lewis(y) but not Lewis(b) are functional glycans. 692/29 showed good anti-tumour responses in vivo and is a strong therapeutic candidate.

Host :

Mouse

Immunogen :

Colonic Adenoma membranes

Subclass :

IgG3 kappa

Myeloma Used :

P3/NS1/1-Ag4.1

Research Area :

Cancer, Epigenetics & Nuclear Signalling

more info or order :

Ximbio product webpage