product summary
company name :
Ximbio
product type :
antibody
product name :
Anti-ErbB2 [ICR55]
catalog :
153391
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
2064
reactivity :
human
application :
western blot, immunohistochemistry, immunoprecipitation
more info or order :
Ximbio product webpage
product information
Name :
Anti-ErbB2 [ICR55]
Catalogue Number :
153391
Applications :
IHC IP WB
Antigen/Gene or Protein Targets :
Erb-B2
Synonyms :
ERBB2, Tyrosine kinase type cell surface receptor HER2, Human Epidermal Growth Factor Receptor 2, Proto-Oncogene C-ErbB-2, HER-2/Neu, HER2, Receptor Tyrosine-Protein Kinase ErbB-2
Reactivity :
Human
Relevance :
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Host :
Rat
Immunogen :
Recombinant full length protein (Human)
Subclass :
IgG2a
Molecular Weight (kDa) :
77
Strain :
CBA
Research Area :
Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction
more info or order :
Ximbio product webpage
company information
Ximbio
enquiries@ximbio.com
ximbio.com