Anti-CD74 [BU45] | Ximbio 153218 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-CD74 [BU45]

catalog :

153218

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

972

reactivity :

human

application :

immunohistochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-CD74 [BU45]

Catalogue Number :

153218

Applications :

IHC

Antigen/Gene or Protein Targets :

CD74

Synonyms :

HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; Cluster of Differentiation 74

Reactivity :

Human

Relevance :

CD74 is expressed primarily by antigen presenting cells such as B lymphocytes , macrophages and monocytes together, with many epithelialcells. CD74 may exist in different isoforms ranging in size from 33 to 41kDa, depending on genetic splicing. CD74 is a type II transmembrane protein which binds to the binding groove of nacent MHC class II alpha/beta heterodimers preventing their premature association with endogenous polypeptides. The half life of CD74 on the cell surface is relatively short lasting only 3 to 4 min, before internalization. It has been suggested that CD74 on the cell surface binds MHC class II molecules which have lost their antigenic peptide promoting internalization and reloading with antigenic peptide.

Host :

Mouse

Immunogen :

B lymphoblastoid cell line: HFB1

Subclass :

IgG1

Strain :

Balb/c

Research Area :

Immunology

more info or order :

Ximbio product webpage