Anti-Phospho-Rb (Thr356) [7F10] | Ximbio 153190 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Phospho-Rb (Thr356) [7F10]

catalog :

153190

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

5925

reactivity :

human, mouse

application :

western blot, immunohistochemistry

more info or order :

Ximbio product webpage

product information

Name :

Anti-Phospho-Rb (Thr356) [7F10]

Catalogue Number :

153190

Applications :

IHC WB

Antigen/Gene or Protein Targets :

Rb (phospho Thr356)

Synonyms :

Retinoblastoma 1; RB1; p105-Rb; RB; pp110; pRb; OSRC

Reactivity :

Human and Mouse

Relevance :

Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia. Phosphorylation of Rb at S608 depends on CDK4.

Host :

Rat

Immunogen :

Synthetic peptide COOH-C-ERERpTPRKNN-NH2 coupled to mycobacterium tuberculosis PPD

Subclass :

IgG2a

Molecular Weight (kDa) :

111

Research Area :

Cancer, Cell Cycle, Cell Signaling & Signal Transduction, Gene Expression, Stem Cell Biology

more info or order :

Ximbio product webpage