Anti-Phospho Endosulfine [DF1.1] | Ximbio 153180 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Phospho Endosulfine [DF1.1]

catalog :

153180

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DF1.1

reactivity :

human

application :

western blot

more info or order :

Ximbio product webpage

product information

Name :

Anti-Phospho Endosulfine [DF1.1]

Catalogue Number :

153180

Applications :

Antigen/Gene or Protein Targets :

Phospho Endosulfine

Reactivity :

Xenopus laevis

Relevance :

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. Endosulfine is highly phosphorylated in Xenopus CSF egg extracts but de-phosphorylated when the eggs enter interphase.

Host :

Mouse

Immunogen :

Synthetic peptide - KGQKYFD-Sp-GDYNMAK

Positive Control :

Xenopus CSF (cytostatic factor extract)

Molecular Weight (kDa) :

Research Area :

Neurobiology

Notes :

Raised from mice immunized with amino acids 60-74 from Xenopus and Human endosulfine where amino acid 67 is phospho-serine: Human [KGQKYFD-Sp-GDYNMAK] (Ser 67) Reacts against Xenopus Phospho Endosulfine. Not tested against human and mouse.

more info or order :

Ximbio product webpage