Anti-Acetyl SMC3 [DP3.1] | Ximbio 153177 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Acetyl SMC3 [DP3.1]

catalog :

153177

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DP3.1

reactivity :

human

application :

western blot

more info or order :

Ximbio product webpage

product information

Name :

Anti-Acetyl SMC3 [DP3.1]

Catalogue Number :

153177

Applications :

Antigen/Gene or Protein Targets :

Acetyl SMC3

Reactivity :

Xenopus laevis

Relevance :

SMC3 is a central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement. SMC3 is unacetylated in egg extracts. It is only acetylated in chromatin preparations from extracts where the DNA has replicated.

Host :

Mouse

Immunogen :

Synthetic peptide - EEVSLRRVIGAKacetyl Kacetyl DQYFLDKK

Positive Control :

Xenopus chromatin extract

Molecular Weight (kDa) :

141

Research Area :

Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling

Notes :

Raised from mice immunized with the peptide sequence: EEVSLRRVIGAKacetyl Kacetyl DQYFLDKK corrosponding to amino acids 94 -114 of Xenopus laevis SMC3 The epitope recognised by these antibodies is identical to the human sequence amino acid 98 -114 Human [LRRVIGAKacetyl Kacetyl DQYFLDKK] (Lys 105, Lys 106) Xenopus [LRRVIGAKacetyl Kacetyl DQYFLDKK] DP4.1 reacts against Xenopus Acetyl SMC3. Not tested against human and mouse.

more info or order :

Ximbio product webpage