Anti-Lewis y/b hapten [NCRC37] | Ximbio 152939 product information

product summary

company name :

Ximbio

product type :

antibody

product name :

Anti-Lewis y/b hapten [NCRC37]

catalog :

152939

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1056

reactivity :

human

application :

ELISA, immunohistochemistry, FACS

more info or order :

Ximbio product webpage

product information

Name :

Anti-Lewis y/b hapten [NCRC37]

Catalogue Number :

152939

Applications :

ELISA FACS IHC Fn

Antigen/Gene or Protein Targets :

Sialyltetraosylceramiden antigen on colorectal tumor cell surface

Reactivity :

Human

Relevance :

Blood group related antigens are a group of carbohydrate determinants present on both glycoproteins and glycolipids. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Lewis- y/b is a cell surface carbohydrate blood group antigen expressed at very low levels in normal tissue, but often found to be over-expressed on breast, lung, colon and ovarian cancer cells. Lewis-y antigen, a difucosylatedtetrasaccharide, is found on type 2 blood group oligosaccharides. The antibody, NCRC37, is a pan-reactive, anti-colorectal tumour antibody and binds strongly to coloretal tumour cells and to post mortem cryopreserved tissues of brain, spleen, heat, lung, kidney, testes, oesophagus or stomach. Lewis y antigen has been evaluated as a clinical marker for the diagnosis and prognosis of cholangiocarcinoma, hepatocellular carcinoma and breast cancer.

Host :

Mouse

Immunogen :

Tissue cultured colorectal tumor cell lines (C170, C146, Colo205, and JW)

Subclass :

IgG1

Positive Control :

C14 (NCRC10)

Myeloma Used :

NS0

Strain :

Balb/c

Research Area :

Cardiovascular, Immunology

Notes :

NCRC37 is also referred to as SC104. The antibody does not bind to blood lympocytes, granulocytes, bone marrow progenitor cells, GM1, GD1a, GT1b, or sialyl LewisX antigens. This antibody directly induces tumor cell death without the need for immune effector cells or complement. NCRC37 is used at 1-5ug/ml for immunocytochemical analysis.

more info or order :

Ximbio product webpage